Green hemostatic sponge-like scaffold composed of soy protein and chitin for the treatment of epistaxis
Epistaxis is one of the most common otorhinolaryngology emergencies worldwide. Although there are currently several treatments available, they present several disadvantages. This, in addition to the increasing social need of being environmentally respectful, led us to investigate whether a sponge-li...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006422000710 |
| _version_ | 1818507581499375616 |
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| author | Jon Jimenez-Martin Kevin Las Heras Alaitz Etxabide Jone Uranga Koro de la Caba Pedro Guerrero Manoli Igartua Edorta Santos-Vizcaino Rosa Maria Hernandez |
| author_facet | Jon Jimenez-Martin Kevin Las Heras Alaitz Etxabide Jone Uranga Koro de la Caba Pedro Guerrero Manoli Igartua Edorta Santos-Vizcaino Rosa Maria Hernandez |
| author_sort | Jon Jimenez-Martin |
| collection | DOAJ |
| description | Epistaxis is one of the most common otorhinolaryngology emergencies worldwide. Although there are currently several treatments available, they present several disadvantages. This, in addition to the increasing social need of being environmentally respectful, led us to investigate whether a sponge-like scaffold (SP–CH) produced from natural by-products of the food industry — soy protein and β-chitin — can be employed as a nasal pack for the treatment of epistaxis. To evaluate the potential of our material as a nasal pack, it was compared with two of the most commonly used nasal packs in the clinic: a basic gauze and the gold standard Merocel®. Our SP-CH presented great physicochemical and mechanical properties, lost weight in aqueous medium, and could even partially degrade when incubated in blood. It was shown to be both biocompatible and hemocompatible in vitro, clearing up any doubt about its safety. It showed increased blood clotting capacity in vitro, as well as increased capacity to bind both red blood cells and platelets, compared to the standard gauze and Merocel®. Finally, a rat-tail amputation model revealed that our SP-CH could even reduce bleeding time in vivo. This work, carried out from a circular economy approach, demonstrates that a green strategy can be followed to manufacture nasal packs using valorized by-products of the food industry, with equal or even better hemostatic properties than the gold standard in the clinic. |
| first_indexed | 2024-12-10T22:20:15Z |
| format | Article |
| id | doaj.art-7d6931be3ebc4126a70411d736761a5e |
| institution | Directory Open Access Journal |
| issn | 2590-0064 |
| language | English |
| last_indexed | 2024-12-10T22:20:15Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj.art-7d6931be3ebc4126a70411d736761a5e2022-12-22T01:31:20ZengElsevierMaterials Today Bio2590-00642022-06-0115100273Green hemostatic sponge-like scaffold composed of soy protein and chitin for the treatment of epistaxisJon Jimenez-Martin0Kevin Las Heras1Alaitz Etxabide2Jone Uranga3Koro de la Caba4Pedro Guerrero5Manoli Igartua6Edorta Santos-Vizcaino7Rosa Maria Hernandez8NanoBioCel Research Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country (UPV/EHU), Paseo de La Universidad 7, 01006 Vitoria Gasteiz, SpainNanoBioCel Research Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country (UPV/EHU), Paseo de La Universidad 7, 01006 Vitoria Gasteiz, Spain; Bioaraba, NanoBioCel Research Group, Vitoria Gasteiz, SpainBIOMAT Research Group, University of the Basque Country (UPV/EHU), Escuela de Ingeniería de Gipuzkoa, Plaza de Europa 1, 20018 Donostia-San Sebastián, SpainBIOMAT Research Group, University of the Basque Country (UPV/EHU), Escuela de Ingeniería de Gipuzkoa, Plaza de Europa 1, 20018 Donostia-San Sebastián, SpainBIOMAT Research Group, University of the Basque Country (UPV/EHU), Escuela de Ingeniería de Gipuzkoa, Plaza de Europa 1, 20018 Donostia-San Sebastián, Spain; BCMaterials, Basque Center for Materials, Applications and Nanostructures, UPV/EHU Science Park, 48940, Leioa, SpainBIOMAT Research Group, University of the Basque Country (UPV/EHU), Escuela de Ingeniería de Gipuzkoa, Plaza de Europa 1, 20018 Donostia-San Sebastián, Spain; BCMaterials, Basque Center for Materials, Applications and Nanostructures, UPV/EHU Science Park, 48940, Leioa, Spain; Proteinmat Materials SL, Avenida de Tolosa 72, 20018 Donostia-San Sebastian, SpainNanoBioCel Research Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country (UPV/EHU), Paseo de La Universidad 7, 01006 Vitoria Gasteiz, Spain; Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Institute of Health Carlos III, Madrid, Spain; Bioaraba, NanoBioCel Research Group, Vitoria Gasteiz, SpainNanoBioCel Research Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country (UPV/EHU), Paseo de La Universidad 7, 01006 Vitoria Gasteiz, Spain; Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Institute of Health Carlos III, Madrid, Spain; Bioaraba, NanoBioCel Research Group, Vitoria Gasteiz, Spain; Corresponding author. NanoBioCel Research Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country (UPV/EHU), Paseo de la Universidad 7, 01006 Vitoria Gasteiz, Spain.NanoBioCel Research Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country (UPV/EHU), Paseo de La Universidad 7, 01006 Vitoria Gasteiz, Spain; Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Institute of Health Carlos III, Madrid, Spain; Bioaraba, NanoBioCel Research Group, Vitoria Gasteiz, Spain; Corresponding author. NanoBioCel Research Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country (UPV/EHU), Paseo de la Universidad 7, 01006 Vitoria Gasteiz, Spain.Epistaxis is one of the most common otorhinolaryngology emergencies worldwide. Although there are currently several treatments available, they present several disadvantages. This, in addition to the increasing social need of being environmentally respectful, led us to investigate whether a sponge-like scaffold (SP–CH) produced from natural by-products of the food industry — soy protein and β-chitin — can be employed as a nasal pack for the treatment of epistaxis. To evaluate the potential of our material as a nasal pack, it was compared with two of the most commonly used nasal packs in the clinic: a basic gauze and the gold standard Merocel®. Our SP-CH presented great physicochemical and mechanical properties, lost weight in aqueous medium, and could even partially degrade when incubated in blood. It was shown to be both biocompatible and hemocompatible in vitro, clearing up any doubt about its safety. It showed increased blood clotting capacity in vitro, as well as increased capacity to bind both red blood cells and platelets, compared to the standard gauze and Merocel®. Finally, a rat-tail amputation model revealed that our SP-CH could even reduce bleeding time in vivo. This work, carried out from a circular economy approach, demonstrates that a green strategy can be followed to manufacture nasal packs using valorized by-products of the food industry, with equal or even better hemostatic properties than the gold standard in the clinic.http://www.sciencedirect.com/science/article/pii/S2590006422000710EpistaxisNasal packHemostasisSustainability |
| spellingShingle | Jon Jimenez-Martin Kevin Las Heras Alaitz Etxabide Jone Uranga Koro de la Caba Pedro Guerrero Manoli Igartua Edorta Santos-Vizcaino Rosa Maria Hernandez Green hemostatic sponge-like scaffold composed of soy protein and chitin for the treatment of epistaxis Materials Today Bio Epistaxis Nasal pack Hemostasis Sustainability |
| title | Green hemostatic sponge-like scaffold composed of soy protein and chitin for the treatment of epistaxis |
| title_full | Green hemostatic sponge-like scaffold composed of soy protein and chitin for the treatment of epistaxis |
| title_fullStr | Green hemostatic sponge-like scaffold composed of soy protein and chitin for the treatment of epistaxis |
| title_full_unstemmed | Green hemostatic sponge-like scaffold composed of soy protein and chitin for the treatment of epistaxis |
| title_short | Green hemostatic sponge-like scaffold composed of soy protein and chitin for the treatment of epistaxis |
| title_sort | green hemostatic sponge like scaffold composed of soy protein and chitin for the treatment of epistaxis |
| topic | Epistaxis Nasal pack Hemostasis Sustainability |
| url | http://www.sciencedirect.com/science/article/pii/S2590006422000710 |
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