Insulin Resistance as a Risk Factor for Cutaneous Melanoma. A Case Control Study and Risk-Assessment Nomograms
Insulin resistance and obesity are suggested to have a key role in the molecular pathogenesis of various disorders, including several malignancies. Moreover, insulin resistance has recently been found to be associated with cutaneous and uveal melanoma, while a variable positive correlation between o...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-11-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2019.00757/full |
| _version_ | 1818127077608521728 |
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| author | Alessandro Scoppola Lidia Strigari Agnese Barnabei Pierpaolo Petasecca Federica De Galitiis Claudia Angela Maria Fulgenzi Mario Roselli Antonino De Lorenzo Laura Di Renzo Paolo Marchetti Paolo Marchetti Francesco Torino |
| author_facet | Alessandro Scoppola Lidia Strigari Agnese Barnabei Pierpaolo Petasecca Federica De Galitiis Claudia Angela Maria Fulgenzi Mario Roselli Antonino De Lorenzo Laura Di Renzo Paolo Marchetti Paolo Marchetti Francesco Torino |
| author_sort | Alessandro Scoppola |
| collection | DOAJ |
| description | Insulin resistance and obesity are suggested to have a key role in the molecular pathogenesis of various disorders, including several malignancies. Moreover, insulin resistance has recently been found to be associated with cutaneous and uveal melanoma, while a variable positive correlation between obesity and the risk of cutaneous melanoma was also found at least in men. The present trial aims at confirming whether insulin resistance, assessed with the homeostasis model assessment of insulin resistance (HOMA-IR) and the quantitative insulin sensitivity check index (QUICKI), is a risk factor for cutaneous melanoma. One hundred and thirty patients diagnosed with cutaneous melanoma and 130 age-, sex-, and skin phototype-matched controls were evaluated. At the univariate and multivariate analysis, the diagnosis of cutaneous melanoma was inversely related with insulin resistance (HOMA-IR) and positively with BMI (p = 0.0014 and p = 0.008, respectively). Consistently, insulin sensitivity (QUICKI) and BMI resulted positively associated with the diagnosis of cutaneous melanoma (p = 0.0001 and p = 0.0026, respectively). The results obtained are partially in agreement with those reported in the literature. By comparing our data with those generated by other studies, inconsistencies in key features among subgroups of different trials have emerged, possibly affecting final correlations. Based on insulin resistance/sensitivity, fasting insulinemia/glycemia, and BMI values collected from patients who participated in the present trial, two nomograms potentially assessing the risk of cutaneous melanoma have been generated. Molecular aspects sustain a role for insulin resistance in the carcinogenesis of cutaneous melanoma, but clinical data remain uncertain. Larger, well-balanced, correlative trials are still needed to define the potential role of insulin resistance in the carcinogenesis of cutaneous melanoma. |
| first_indexed | 2024-12-11T07:11:37Z |
| format | Article |
| id | doaj.art-7d6a41ed731a418c922d3c298a5b3941 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-11T07:11:37Z |
| publishDate | 2019-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-7d6a41ed731a418c922d3c298a5b39412022-12-22T01:16:20ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922019-11-011010.3389/fendo.2019.00757491614Insulin Resistance as a Risk Factor for Cutaneous Melanoma. A Case Control Study and Risk-Assessment NomogramsAlessandro Scoppola0Lidia Strigari1Agnese Barnabei2Pierpaolo Petasecca3Federica De Galitiis4Claudia Angela Maria Fulgenzi5Mario Roselli6Antonino De Lorenzo7Laura Di Renzo8Paolo Marchetti9Paolo Marchetti10Francesco Torino11Department of Oncology and Dermatological Oncology, Istituto Dermopatico dell'Immacolata-IRCCS, Rome, ItalyDepartment of Medical Physics, S. Orsola Malpighi University Hospital, Bologna, ItalyEndocrinology Unit, IRCCS Regina Elena National Cancer Institute, Rome, ItalyDepartment of Oncology and Dermatological Oncology, Istituto Dermopatico dell'Immacolata-IRCCS, Rome, ItalyDepartment of Oncology and Dermatological Oncology, Istituto Dermopatico dell'Immacolata-IRCCS, Rome, ItalyDepartment of Systems Medicine, Medical Oncology, University of Rome Tor Vergata, Rome, ItalyDepartment of Systems Medicine, Medical Oncology, University of Rome Tor Vergata, Rome, ItalySection of Clinical Nutrition and Nutrigenomic, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, ItalySection of Clinical Nutrition and Nutrigenomic, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, ItalyDepartment of Oncology and Dermatological Oncology, Istituto Dermopatico dell'Immacolata-IRCCS, Rome, ItalyDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, ItalyDepartment of Systems Medicine, Medical Oncology, University of Rome Tor Vergata, Rome, ItalyInsulin resistance and obesity are suggested to have a key role in the molecular pathogenesis of various disorders, including several malignancies. Moreover, insulin resistance has recently been found to be associated with cutaneous and uveal melanoma, while a variable positive correlation between obesity and the risk of cutaneous melanoma was also found at least in men. The present trial aims at confirming whether insulin resistance, assessed with the homeostasis model assessment of insulin resistance (HOMA-IR) and the quantitative insulin sensitivity check index (QUICKI), is a risk factor for cutaneous melanoma. One hundred and thirty patients diagnosed with cutaneous melanoma and 130 age-, sex-, and skin phototype-matched controls were evaluated. At the univariate and multivariate analysis, the diagnosis of cutaneous melanoma was inversely related with insulin resistance (HOMA-IR) and positively with BMI (p = 0.0014 and p = 0.008, respectively). Consistently, insulin sensitivity (QUICKI) and BMI resulted positively associated with the diagnosis of cutaneous melanoma (p = 0.0001 and p = 0.0026, respectively). The results obtained are partially in agreement with those reported in the literature. By comparing our data with those generated by other studies, inconsistencies in key features among subgroups of different trials have emerged, possibly affecting final correlations. Based on insulin resistance/sensitivity, fasting insulinemia/glycemia, and BMI values collected from patients who participated in the present trial, two nomograms potentially assessing the risk of cutaneous melanoma have been generated. Molecular aspects sustain a role for insulin resistance in the carcinogenesis of cutaneous melanoma, but clinical data remain uncertain. Larger, well-balanced, correlative trials are still needed to define the potential role of insulin resistance in the carcinogenesis of cutaneous melanoma.https://www.frontiersin.org/article/10.3389/fendo.2019.00757/fullinsulin resistancecutaneous melanomaHOMA-IRQUICKIbody mass index |
| spellingShingle | Alessandro Scoppola Lidia Strigari Agnese Barnabei Pierpaolo Petasecca Federica De Galitiis Claudia Angela Maria Fulgenzi Mario Roselli Antonino De Lorenzo Laura Di Renzo Paolo Marchetti Paolo Marchetti Francesco Torino Insulin Resistance as a Risk Factor for Cutaneous Melanoma. A Case Control Study and Risk-Assessment Nomograms Frontiers in Endocrinology insulin resistance cutaneous melanoma HOMA-IR QUICKI body mass index |
| title | Insulin Resistance as a Risk Factor for Cutaneous Melanoma. A Case Control Study and Risk-Assessment Nomograms |
| title_full | Insulin Resistance as a Risk Factor for Cutaneous Melanoma. A Case Control Study and Risk-Assessment Nomograms |
| title_fullStr | Insulin Resistance as a Risk Factor for Cutaneous Melanoma. A Case Control Study and Risk-Assessment Nomograms |
| title_full_unstemmed | Insulin Resistance as a Risk Factor for Cutaneous Melanoma. A Case Control Study and Risk-Assessment Nomograms |
| title_short | Insulin Resistance as a Risk Factor for Cutaneous Melanoma. A Case Control Study and Risk-Assessment Nomograms |
| title_sort | insulin resistance as a risk factor for cutaneous melanoma a case control study and risk assessment nomograms |
| topic | insulin resistance cutaneous melanoma HOMA-IR QUICKI body mass index |
| url | https://www.frontiersin.org/article/10.3389/fendo.2019.00757/full |
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