The Relationship between Abnormal Circadian Blood Pressure Rhythm and Risk of Readmission in Patients with Heart Failure with Preserved Ejection Fraction
<p class="first" id="d17682457e154"> <b>Objective:</b> Abnormal circadian blood pressure rhythm has been revealed to be associated with hypertensive target organ damage and cardiovascular events, but its association with...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Compuscript Ltd
2021-04-01
|
| Series: | Cardiovascular Innovations and Applications |
| Online Access: | https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2021.0014 |
| Summary: | <p class="first" id="d17682457e154">
<b>Objective:</b> Abnormal circadian blood pressure rhythm has been revealed to be associated with
hypertensive target organ damage and cardiovascular events, but its association with
readmission risk in patients with heart failure with preserved ejection fraction (HFpEF)
remains unknown. We conducted a retrospective study to explore the relationship between
circadian blood pressure rhythm and readmission risk in HFpEF patients.
</p><p id="d17682457e159">
<b>Methods:</b> We retrospectively collected baseline and follow-up data on HFpEF patients who underwent
ambulatory blood pressure monitoring (ABPM) from May 2015 to October 2019. Patient
circadian blood pressure rhythms defined by ABPM were grouped as dipper, nondipper,
or riser patterns. Univariate and multivariate linear regression analyses were performed
to assess the association between circadian blood pressure rhythm and readmission
risk.
</p><p id="d17682457e164">
<b>Results:</b> A total of 122 patients were enrolled in this study. The mean age and ejection fraction
were 69.87 years and 61.44%, respectively, with mean the N-terminal pro-B-type natriuretic
peptide (NT-proBNP) level being 1048.15 pg/mL. There were significant differences
in the 24-hour systolic blood pressure (SBP), sleep SBP, and sleep diastolic blood
pressure (DBP) among the three groups, where the 24-hour SBP, sleep SBP, and sleep
DBP in the riser pattern group were markedly higher than in the dipper pattern group.
Notably, serum NT-proBNP levels, the proportion of patients readmitted for heart failure
and the mean number of admissions differed markedly among three groups. Instructively,
multivariate linear regression analysis showed that the riser pattern was a significant
and independent risk factor for increased serum NT-proBNP level (
<i>β</i> = 929.16, 95% confidence interval 178.79–1679.53, P = 0.016). In multivariate logistic
regression analysis, the riser pattern was demonstrated to be a significant risk factor
for readmission (odds ratio 11.23, 95% confidence interval 2.01–62.67, P = 0.006)
in HFpEF patients.
</p><p id="d17682457e172">
<b>Conclusion:</b> The riser blood pressure pattern is a potential risk factor for elevated serum NT-proBNP
level and readmission in HFpEF patients.
</p> |
|---|---|
| ISSN: | 2009-8618 2009-8782 |