Tumor-Associated Macrophages: New Horizons for Pituitary Adenoma Researches
Macrophages are one of the most common infiltrating immune cells and an essential component of tumor microenvironment. Macrophages and the soluble cytokines and chemokines produced play an important role in tumorigenesis, progression, invasion and metastasis in solid tumors. Despite the multiple stu...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2021.785050/full |
| _version_ | 1828973787773665280 |
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| author | Changxi Han Shaojian Lin Xingyu Lu Li Xue Zhe Bao Wu |
| author_facet | Changxi Han Shaojian Lin Xingyu Lu Li Xue Zhe Bao Wu |
| author_sort | Changxi Han |
| collection | DOAJ |
| description | Macrophages are one of the most common infiltrating immune cells and an essential component of tumor microenvironment. Macrophages and the soluble cytokines and chemokines produced play an important role in tumorigenesis, progression, invasion and metastasis in solid tumors. Despite the multiple studies in other solid tumors, there is little known about macrophages in pituitary adenomas. Recently, studies about pituitary adenoma-infiltrated macrophages have been emerging, including the immunohistochemical and immunophenotypic analysis of the pituitary adenomas and further studies into the mechanism of the crosstalk between macrophages and tumor cells in vivo and in vitro. These studies have offered us new insights into the polarization of macrophages and its role in tumorigenesis, progression and invasion of pituitary adenomas. This review describes the advances in the field of pituitary adenoma-infiltrated macrophages and the prospect of targeting macrophages as cancer therapy in pituitary adenoma. |
| first_indexed | 2024-12-14T13:51:23Z |
| format | Article |
| id | doaj.art-7d6ca085cd3b47d8b735b368636f8ac5 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-14T13:51:23Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-7d6ca085cd3b47d8b735b368636f8ac52022-12-21T22:59:04ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-12-011210.3389/fendo.2021.785050785050Tumor-Associated Macrophages: New Horizons for Pituitary Adenoma ResearchesChangxi HanShaojian LinXingyu LuLi XueZhe Bao WuMacrophages are one of the most common infiltrating immune cells and an essential component of tumor microenvironment. Macrophages and the soluble cytokines and chemokines produced play an important role in tumorigenesis, progression, invasion and metastasis in solid tumors. Despite the multiple studies in other solid tumors, there is little known about macrophages in pituitary adenomas. Recently, studies about pituitary adenoma-infiltrated macrophages have been emerging, including the immunohistochemical and immunophenotypic analysis of the pituitary adenomas and further studies into the mechanism of the crosstalk between macrophages and tumor cells in vivo and in vitro. These studies have offered us new insights into the polarization of macrophages and its role in tumorigenesis, progression and invasion of pituitary adenomas. This review describes the advances in the field of pituitary adenoma-infiltrated macrophages and the prospect of targeting macrophages as cancer therapy in pituitary adenoma.https://www.frontiersin.org/articles/10.3389/fendo.2021.785050/fullpituitary adenomamacrophagestumor microenvironmentimmune celltherapy |
| spellingShingle | Changxi Han Shaojian Lin Xingyu Lu Li Xue Zhe Bao Wu Tumor-Associated Macrophages: New Horizons for Pituitary Adenoma Researches Frontiers in Endocrinology pituitary adenoma macrophages tumor microenvironment immune cell therapy |
| title | Tumor-Associated Macrophages: New Horizons for Pituitary Adenoma Researches |
| title_full | Tumor-Associated Macrophages: New Horizons for Pituitary Adenoma Researches |
| title_fullStr | Tumor-Associated Macrophages: New Horizons for Pituitary Adenoma Researches |
| title_full_unstemmed | Tumor-Associated Macrophages: New Horizons for Pituitary Adenoma Researches |
| title_short | Tumor-Associated Macrophages: New Horizons for Pituitary Adenoma Researches |
| title_sort | tumor associated macrophages new horizons for pituitary adenoma researches |
| topic | pituitary adenoma macrophages tumor microenvironment immune cell therapy |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2021.785050/full |
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