A Functional Magnetic Resonance Imaging Approach for Language Laterality Assessment in Young Children
Functional magnetic resonance imaging (fMRI) is a usable technique to determine hemispheric dominance of language function, but high-quality fMRI images are difficult to acquire in young children. Here we aimed to develop and validate an fMRI approach to reliably determine hemispheric language domin...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-11-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2020.587593/full |
| _version_ | 1818456959983026176 |
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| author | Lisette Charbonnier Mathijs A. H. Raemaekers Philippe A. Cornelisse Maxime Verwoert Kees P. J. Braun Nick F. Ramsey Mariska J. Vansteensel |
| author_facet | Lisette Charbonnier Mathijs A. H. Raemaekers Philippe A. Cornelisse Maxime Verwoert Kees P. J. Braun Nick F. Ramsey Mariska J. Vansteensel |
| author_sort | Lisette Charbonnier |
| collection | DOAJ |
| description | Functional magnetic resonance imaging (fMRI) is a usable technique to determine hemispheric dominance of language function, but high-quality fMRI images are difficult to acquire in young children. Here we aimed to develop and validate an fMRI approach to reliably determine hemispheric language dominance in young children. We designed two new tasks (story, SR; Letter picture matching, LPM) that aimed to match the interests and the levels of cognitive development of young children. We studied 32 healthy children (6–10 years old, median age 8.7 years) and seven children with epilepsy (7–11 years old, median age 8.6 years) and compared the lateralization index of the new tasks with those of a well-validated task (verb generation, VG) and with clinical measures of hemispheric language dominance. A conclusive assessment of hemispheric dominance (lateralization index ≤-0.2 or ≥0.2) was obtained for 94% of the healthy participants who performed both new tasks. At least one new task provided conclusive language laterality assessment in six out of seven participants with epilepsy. The new tasks may contribute to assessing language laterality in young and preliterate children and may benefit children who are scheduled for surgical treatment of disorders such as epilepsy. |
| first_indexed | 2024-12-14T22:34:58Z |
| format | Article |
| id | doaj.art-7d6ed2e120dd4234b39b9098d3d05ac9 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-14T22:34:58Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-7d6ed2e120dd4234b39b9098d3d05ac92022-12-21T22:45:10ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602020-11-01810.3389/fped.2020.587593587593A Functional Magnetic Resonance Imaging Approach for Language Laterality Assessment in Young ChildrenLisette Charbonnier0Mathijs A. H. Raemaekers1Philippe A. Cornelisse2Maxime Verwoert3Kees P. J. Braun4Nick F. Ramsey5Mariska J. Vansteensel6Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, NetherlandsDepartment of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, NetherlandsDepartment of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, NetherlandsDepartment of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, NetherlandsDepartment of Child Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, NetherlandsDepartment of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, NetherlandsDepartment of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, NetherlandsFunctional magnetic resonance imaging (fMRI) is a usable technique to determine hemispheric dominance of language function, but high-quality fMRI images are difficult to acquire in young children. Here we aimed to develop and validate an fMRI approach to reliably determine hemispheric language dominance in young children. We designed two new tasks (story, SR; Letter picture matching, LPM) that aimed to match the interests and the levels of cognitive development of young children. We studied 32 healthy children (6–10 years old, median age 8.7 years) and seven children with epilepsy (7–11 years old, median age 8.6 years) and compared the lateralization index of the new tasks with those of a well-validated task (verb generation, VG) and with clinical measures of hemispheric language dominance. A conclusive assessment of hemispheric dominance (lateralization index ≤-0.2 or ≥0.2) was obtained for 94% of the healthy participants who performed both new tasks. At least one new task provided conclusive language laterality assessment in six out of seven participants with epilepsy. The new tasks may contribute to assessing language laterality in young and preliterate children and may benefit children who are scheduled for surgical treatment of disorders such as epilepsy.https://www.frontiersin.org/articles/10.3389/fped.2020.587593/fullfMRIchildrenlanguagemappinglateralization |
| spellingShingle | Lisette Charbonnier Mathijs A. H. Raemaekers Philippe A. Cornelisse Maxime Verwoert Kees P. J. Braun Nick F. Ramsey Mariska J. Vansteensel A Functional Magnetic Resonance Imaging Approach for Language Laterality Assessment in Young Children Frontiers in Pediatrics fMRI children language mapping lateralization |
| title | A Functional Magnetic Resonance Imaging Approach for Language Laterality Assessment in Young Children |
| title_full | A Functional Magnetic Resonance Imaging Approach for Language Laterality Assessment in Young Children |
| title_fullStr | A Functional Magnetic Resonance Imaging Approach for Language Laterality Assessment in Young Children |
| title_full_unstemmed | A Functional Magnetic Resonance Imaging Approach for Language Laterality Assessment in Young Children |
| title_short | A Functional Magnetic Resonance Imaging Approach for Language Laterality Assessment in Young Children |
| title_sort | functional magnetic resonance imaging approach for language laterality assessment in young children |
| topic | fMRI children language mapping lateralization |
| url | https://www.frontiersin.org/articles/10.3389/fped.2020.587593/full |
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