Secretion of parathyroid hormone may be coupled to insulin secretion in humans
Objective: Parathyroid hormone (PTH) is a key hormone in regulation of calcium homeostasis and its secretion is regulated by calcium. Secretion of PTH is attenuated during intake of nutrients, but the underlying mechanism(s) are unknown. We hypothesized that insulin acts as an acute regulator of PTH...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Bioscientifica
2020-08-01
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| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | https://ec.bioscientifica.com/view/journals/ec/9/7/EC-20-0092.xml |
| _version_ | 1818157861563269120 |
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| author | Marie Reeberg Sass Nicolai Jacob Wewer Albrechtsen Jens Pedersen Kristine Juul Hare Nis Borbye-Lorenzen Katalin Kiss Tina Vilsbøll Filip Krag Knop Steen Seier Poulsen Niklas Rye Jørgensen Jens Juul Holst Cathrine Ørskov Bolette Hartmann |
| author_facet | Marie Reeberg Sass Nicolai Jacob Wewer Albrechtsen Jens Pedersen Kristine Juul Hare Nis Borbye-Lorenzen Katalin Kiss Tina Vilsbøll Filip Krag Knop Steen Seier Poulsen Niklas Rye Jørgensen Jens Juul Holst Cathrine Ørskov Bolette Hartmann |
| author_sort | Marie Reeberg Sass |
| collection | DOAJ |
| description | Objective: Parathyroid hormone (PTH) is a key hormone in regulation of calcium homeostasis and its secretion is regulated by calcium. Secretion of PTH is attenuated during intake of nutrients, but the underlying mechanism(s) are unknown. We hypothesized that insulin acts as an acute regulator of PTH secretion.
Methods: Intact PTH was measured in plasma from patients with T1D and matched healthy individuals during 4-h oral glucose tolerance tests (OGTT) and isoglycemic i.v. glucose infusions on 2 separate days. In addition, expression of insulin receptors on surgical specimens of parathyroid glands was assessed by immunochemistry (IHC) and quantitative PCR (qPCR).
Results: The inhibition of PTH secretion was more pronounced in healthy individuals compared to patients with T1D during an OGTT (decrementalAUC0–240min: −5256 ± 3954 min × ng/L and −2408 ± 1435 min × ng/L, P = 0.030). Insulin levels correlated significantly and inversely with PTH levels, also after adjusting for levels of several gut hormones and BMI (P = 0.002). Expression of insulin receptors in human parathyroid glands was detected by both IHC and qPCR.
Conclusion: Our study suggests that insulin may act as an acute regulator of PTH secretion in humans. |
| first_indexed | 2024-12-11T15:20:55Z |
| format | Article |
| id | doaj.art-7d6f9a5132394af7a1ecc3161dee577d |
| institution | Directory Open Access Journal |
| issn | 2049-3614 2049-3614 |
| language | English |
| last_indexed | 2024-12-11T15:20:55Z |
| publishDate | 2020-08-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-7d6f9a5132394af7a1ecc3161dee577d2022-12-22T01:00:22ZengBioscientificaEndocrine Connections2049-36142049-36142020-08-0197747754https://doi.org/10.1530/EC-20-0092Secretion of parathyroid hormone may be coupled to insulin secretion in humansMarie Reeberg Sass0Nicolai Jacob Wewer Albrechtsen1Jens Pedersen2Kristine Juul Hare3Nis Borbye-Lorenzen4Katalin Kiss5Tina Vilsbøll6Filip Krag Knop7Steen Seier Poulsen8Niklas Rye Jørgensen9Jens Juul Holst10Cathrine Ørskov11Bolette Hartmann12Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, DenmarkDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Endocrinology and Nephrology, Nordsjællands University Hospital, Hillerød, DenmarkDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Center for Neonatal Screening, Department of Congenital Disorders, Statens Serum Institute, Copenhagen, DenmarkDepartment of Pathology, Rigshospitalet, Copenhagen, DenmarkSteno Diabetes Center Copenhagen, Gentofte, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, DenmarkNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Steno Diabetes Center Copenhagen, Gentofte, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, DenmarkDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkDepartment of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkObjective: Parathyroid hormone (PTH) is a key hormone in regulation of calcium homeostasis and its secretion is regulated by calcium. Secretion of PTH is attenuated during intake of nutrients, but the underlying mechanism(s) are unknown. We hypothesized that insulin acts as an acute regulator of PTH secretion. Methods: Intact PTH was measured in plasma from patients with T1D and matched healthy individuals during 4-h oral glucose tolerance tests (OGTT) and isoglycemic i.v. glucose infusions on 2 separate days. In addition, expression of insulin receptors on surgical specimens of parathyroid glands was assessed by immunochemistry (IHC) and quantitative PCR (qPCR). Results: The inhibition of PTH secretion was more pronounced in healthy individuals compared to patients with T1D during an OGTT (decrementalAUC0–240min: −5256 ± 3954 min × ng/L and −2408 ± 1435 min × ng/L, P = 0.030). Insulin levels correlated significantly and inversely with PTH levels, also after adjusting for levels of several gut hormones and BMI (P = 0.002). Expression of insulin receptors in human parathyroid glands was detected by both IHC and qPCR. Conclusion: Our study suggests that insulin may act as an acute regulator of PTH secretion in humans.https://ec.bioscientifica.com/view/journals/ec/9/7/EC-20-0092.xmlt1dminsulin receptorigf1 receptorigf2 receptorogttiigi |
| spellingShingle | Marie Reeberg Sass Nicolai Jacob Wewer Albrechtsen Jens Pedersen Kristine Juul Hare Nis Borbye-Lorenzen Katalin Kiss Tina Vilsbøll Filip Krag Knop Steen Seier Poulsen Niklas Rye Jørgensen Jens Juul Holst Cathrine Ørskov Bolette Hartmann Secretion of parathyroid hormone may be coupled to insulin secretion in humans Endocrine Connections t1dm insulin receptor igf1 receptor igf2 receptor ogtt iigi |
| title | Secretion of parathyroid hormone may be coupled to insulin secretion in humans |
| title_full | Secretion of parathyroid hormone may be coupled to insulin secretion in humans |
| title_fullStr | Secretion of parathyroid hormone may be coupled to insulin secretion in humans |
| title_full_unstemmed | Secretion of parathyroid hormone may be coupled to insulin secretion in humans |
| title_short | Secretion of parathyroid hormone may be coupled to insulin secretion in humans |
| title_sort | secretion of parathyroid hormone may be coupled to insulin secretion in humans |
| topic | t1dm insulin receptor igf1 receptor igf2 receptor ogtt iigi |
| url | https://ec.bioscientifica.com/view/journals/ec/9/7/EC-20-0092.xml |
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