Ethanol Induces Neuroinflammation in a Chronic Plus Binge Mouse Model of Alcohol Use Disorder via TLR4 and MyD88-Dependent Signaling

Ethanol Induces Neuroinflammation in a Chronic Plus Binge Mouse Model of Alcohol Use Disorder via TLR4 and MyD88-Dependent Signaling

Ethanol induces neuroinflammation, which is believed to contribute to the pathogenesis of alcohol use disorder (AUD). Toll-like receptors (TLRs) are a group of pattern recognition receptors (PRRs) expressed on both immune cells, including microglia and astrocytes, and non-immune cells in the central...

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Bibliographic Details
Main Authors: Kalee N. Holloway, James C. Douglas, Tonya M. Rafferty, Cynthia J. M. Kane, Paul D. Drew
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Cells
Subjects:
AUD
neuroinflammation
TLR4
MyD88
TRIF
ethanol
Online Access:https://www.mdpi.com/2073-4409/12/16/2109

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