The effect of sevoflurane versus propofol anesthesia on troponin I after congenital heart surgery, a randomized clinical trial
Background : The ischemic preconditioning phenomenon can save myocardium against move severe ischemic damages and reduce infarction size and furthermore a heart rhythm disturbance. In this study we examine relationship between troponin I (as a structural myocardial protein) level and anesthetic agen...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Advanced Biomedical Research |
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| Online Access: | http://www.advbiores.net/article.asp?issn=2277-9175;year=2015;volume=4;issue=1;spage=86;epage=86;aulast=Mahdavi |
| _version_ | 1818535335773077504 |
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| author | Leila Mahdavi Mohammad Hasan Abdollahi Ahmad Entezari Ehsan Salehi Habibollah Hosseini Syed Hossein Moshtaghioon Azam Rafie Ali Akbar Rahimianfar |
| author_facet | Leila Mahdavi Mohammad Hasan Abdollahi Ahmad Entezari Ehsan Salehi Habibollah Hosseini Syed Hossein Moshtaghioon Azam Rafie Ali Akbar Rahimianfar |
| author_sort | Leila Mahdavi |
| collection | DOAJ |
| description | Background : The ischemic preconditioning phenomenon can save myocardium against move severe ischemic damages and reduce infarction size and furthermore a heart rhythm disturbance. In this study we examine relationship between troponin I (as a structural myocardial protein) level and anesthetic agents in the children.
Materials and Methods: In this study 84 children under 12 years age before cardiac surgery were divided randomly into two groups of 42 each. For anesthetic maintenance sevoflurane with dose of 0.5-1 MAC was used in Group 1 and 100-150 mg/kg/min of intravenous propofol in Group 2 for maintenance of anesthesia. Troponin I level was assessed 2 before and 1 hour after anesthetic induction. Outcome measures included the serum cardiac troponin I level in children before and after surgery in two study groups.
Results: There was no significant difference between two groups in indices and both groups were homogenous in this point of view. The troponin I level after surgery was significantly increased in two groups. In the sevoflurane group it was 0.04 ± 0.12 to 0.05 ± 0.09 ng/ml (P value = 0.003) and the propofol group was 0.12 ± 0.26 to 0.19 ± 0.38 ng/ml (P value = 0.001).
Conclusions: In this study two Anesthetic regimens were compared to assess the mean troponin I level before and after pediatric closed heart surgery, and it was shown that mean troponin level before and after surgery in the sevoflurane group was less than the propofol group. But this result was not statistically significant. These results indicate that although more protective effects of sevoflurane on myocardial injuries during pediatric cardiac surgery is predominant but this effect has no significant difference in the propofol group. |
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| institution | Directory Open Access Journal |
| issn | 2277-9175 2277-9175 |
| language | English |
| last_indexed | 2024-12-11T18:23:29Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
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| series | Advanced Biomedical Research |
| spelling | doaj.art-7d706569728647f7badb7eb0b43252f82022-12-22T00:55:11ZengWolters Kluwer Medknow PublicationsAdvanced Biomedical Research2277-91752277-91752015-01-0141868610.4103/2277-9175.156649The effect of sevoflurane versus propofol anesthesia on troponin I after congenital heart surgery, a randomized clinical trialLeila MahdaviMohammad Hasan AbdollahiAhmad EntezariEhsan SalehiHabibollah HosseiniSyed Hossein MoshtaghioonAzam RafieAli Akbar RahimianfarBackground : The ischemic preconditioning phenomenon can save myocardium against move severe ischemic damages and reduce infarction size and furthermore a heart rhythm disturbance. In this study we examine relationship between troponin I (as a structural myocardial protein) level and anesthetic agents in the children. Materials and Methods: In this study 84 children under 12 years age before cardiac surgery were divided randomly into two groups of 42 each. For anesthetic maintenance sevoflurane with dose of 0.5-1 MAC was used in Group 1 and 100-150 mg/kg/min of intravenous propofol in Group 2 for maintenance of anesthesia. Troponin I level was assessed 2 before and 1 hour after anesthetic induction. Outcome measures included the serum cardiac troponin I level in children before and after surgery in two study groups. Results: There was no significant difference between two groups in indices and both groups were homogenous in this point of view. The troponin I level after surgery was significantly increased in two groups. In the sevoflurane group it was 0.04 ± 0.12 to 0.05 ± 0.09 ng/ml (P value = 0.003) and the propofol group was 0.12 ± 0.26 to 0.19 ± 0.38 ng/ml (P value = 0.001). Conclusions: In this study two Anesthetic regimens were compared to assess the mean troponin I level before and after pediatric closed heart surgery, and it was shown that mean troponin level before and after surgery in the sevoflurane group was less than the propofol group. But this result was not statistically significant. These results indicate that although more protective effects of sevoflurane on myocardial injuries during pediatric cardiac surgery is predominant but this effect has no significant difference in the propofol group.http://www.advbiores.net/article.asp?issn=2277-9175;year=2015;volume=4;issue=1;spage=86;epage=86;aulast=MahdaviHeart surgerypediatricpropofolsevofluraneTroponin I |
| spellingShingle | Leila Mahdavi Mohammad Hasan Abdollahi Ahmad Entezari Ehsan Salehi Habibollah Hosseini Syed Hossein Moshtaghioon Azam Rafie Ali Akbar Rahimianfar The effect of sevoflurane versus propofol anesthesia on troponin I after congenital heart surgery, a randomized clinical trial Advanced Biomedical Research Heart surgery pediatric propofol sevoflurane Troponin I |
| title | The effect of sevoflurane versus propofol anesthesia on troponin I after congenital heart surgery, a randomized clinical trial |
| title_full | The effect of sevoflurane versus propofol anesthesia on troponin I after congenital heart surgery, a randomized clinical trial |
| title_fullStr | The effect of sevoflurane versus propofol anesthesia on troponin I after congenital heart surgery, a randomized clinical trial |
| title_full_unstemmed | The effect of sevoflurane versus propofol anesthesia on troponin I after congenital heart surgery, a randomized clinical trial |
| title_short | The effect of sevoflurane versus propofol anesthesia on troponin I after congenital heart surgery, a randomized clinical trial |
| title_sort | effect of sevoflurane versus propofol anesthesia on troponin i after congenital heart surgery a randomized clinical trial |
| topic | Heart surgery pediatric propofol sevoflurane Troponin I |
| url | http://www.advbiores.net/article.asp?issn=2277-9175;year=2015;volume=4;issue=1;spage=86;epage=86;aulast=Mahdavi |
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