Transcranial pulse stimulation in the treatment of mild neurocognitive disorders
Abstract Objective There are limited effectiveness and potential side effects of existing pharmacological approach in treating mild neurocognitive disorder (NCD). Transcranial pulse stimulation (TPS) applies repetitive single high‐pressure ultrashort shockwave pulses to stimulate the brain, which ha...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-10-01
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| Series: | Annals of Clinical and Translational Neurology |
| Online Access: | https://doi.org/10.1002/acn3.51882 |
| _version_ | 1797659120859348992 |
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| author | Tommy Kwan Hin Fong Teris Cheung Sze Ting Joanna Ngan Kelvin Tong Wai Yan Vivian Lui Wai Chi Chan Corine Sau Man Wong Calvin Pak Wing Cheng |
| author_facet | Tommy Kwan Hin Fong Teris Cheung Sze Ting Joanna Ngan Kelvin Tong Wai Yan Vivian Lui Wai Chi Chan Corine Sau Man Wong Calvin Pak Wing Cheng |
| author_sort | Tommy Kwan Hin Fong |
| collection | DOAJ |
| description | Abstract Objective There are limited effectiveness and potential side effects of existing pharmacological approach in treating mild neurocognitive disorder (NCD). Transcranial pulse stimulation (TPS) applies repetitive single high‐pressure ultrashort shockwave pulses to stimulate the brain, which has been shown to effectively improve cognition in major NCD. However, the effectiveness of TPS in mild NCD patients remained unknown. This study aims to assess the effectiveness and tolerability of TPS with neuro‐navigation in old‐age adults with mild NCD by both clinical and biochemical assessments. Methods An open‐label study recruited older adults with mild NCD to receive neuro‐navigated TPS intervention for two weeks with three sessions per week. Assessments included detailed cognitive assessments, APOE genotype, and brain‐derived neurotrophic factor (BDNF). Results Nineteen participants (12 females and 7 males) completed the whole TPS interventions with no serious adverse effects reported. Repeated measures ANOVA showed statistically significant effects of time on HK‐MoCA (F (3, 54) = 4.99, P = 0.004), 30‐sec interval of Verbal Fluency Test (F (3, 54) = 2.94, P = 0.041), Stroop interference (F (3, 54) = 3.46, P = 0.023), and Chinese IADL (F (3, 54) = 2.78, P = 0.050) after receiving the intervention. Bonferroni post hoc comparisons on HK‐MoCA showed a significant improvement after intervention. There was no significant change in serum BDNF level. Interpretation TPS has brought significant improvement in cognition of elderly with mild NCD. It has a great potential to delay the deterioration of cognition in older adults. The long‐term effect of TPS in cognition would benefit from further large‐scale, randomized, sham‐controlled trials. |
| first_indexed | 2024-03-11T18:09:21Z |
| format | Article |
| id | doaj.art-7d71624c4b2046c1b9550a960dee6b5b |
| institution | Directory Open Access Journal |
| issn | 2328-9503 |
| language | English |
| last_indexed | 2024-03-11T18:09:21Z |
| publishDate | 2023-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj.art-7d71624c4b2046c1b9550a960dee6b5b2023-10-16T20:02:29ZengWileyAnnals of Clinical and Translational Neurology2328-95032023-10-0110101885189010.1002/acn3.51882Transcranial pulse stimulation in the treatment of mild neurocognitive disordersTommy Kwan Hin Fong0Teris Cheung1Sze Ting Joanna Ngan2Kelvin Tong3Wai Yan Vivian Lui4Wai Chi Chan5Corine Sau Man Wong6Calvin Pak Wing Cheng7Department of Psychiatry The University of Hong Kong Hong Kong ChinaSchool of Nursing The Hong Kong Polytechnic University Hong Kong ChinaDepartment of Psychiatry The University of Hong Kong Hong Kong ChinaDepartment of Psychiatry The University of Hong Kong Hong Kong ChinaDepartment of Psychiatry The University of Hong Kong Hong Kong ChinaDepartment of Psychiatry The University of Hong Kong Hong Kong ChinaDivision of Community Medicine and Public Health Practice The University of Hong Kong Hong Kong ChinaDepartment of Psychiatry The University of Hong Kong Hong Kong ChinaAbstract Objective There are limited effectiveness and potential side effects of existing pharmacological approach in treating mild neurocognitive disorder (NCD). Transcranial pulse stimulation (TPS) applies repetitive single high‐pressure ultrashort shockwave pulses to stimulate the brain, which has been shown to effectively improve cognition in major NCD. However, the effectiveness of TPS in mild NCD patients remained unknown. This study aims to assess the effectiveness and tolerability of TPS with neuro‐navigation in old‐age adults with mild NCD by both clinical and biochemical assessments. Methods An open‐label study recruited older adults with mild NCD to receive neuro‐navigated TPS intervention for two weeks with three sessions per week. Assessments included detailed cognitive assessments, APOE genotype, and brain‐derived neurotrophic factor (BDNF). Results Nineteen participants (12 females and 7 males) completed the whole TPS interventions with no serious adverse effects reported. Repeated measures ANOVA showed statistically significant effects of time on HK‐MoCA (F (3, 54) = 4.99, P = 0.004), 30‐sec interval of Verbal Fluency Test (F (3, 54) = 2.94, P = 0.041), Stroop interference (F (3, 54) = 3.46, P = 0.023), and Chinese IADL (F (3, 54) = 2.78, P = 0.050) after receiving the intervention. Bonferroni post hoc comparisons on HK‐MoCA showed a significant improvement after intervention. There was no significant change in serum BDNF level. Interpretation TPS has brought significant improvement in cognition of elderly with mild NCD. It has a great potential to delay the deterioration of cognition in older adults. The long‐term effect of TPS in cognition would benefit from further large‐scale, randomized, sham‐controlled trials.https://doi.org/10.1002/acn3.51882 |
| spellingShingle | Tommy Kwan Hin Fong Teris Cheung Sze Ting Joanna Ngan Kelvin Tong Wai Yan Vivian Lui Wai Chi Chan Corine Sau Man Wong Calvin Pak Wing Cheng Transcranial pulse stimulation in the treatment of mild neurocognitive disorders Annals of Clinical and Translational Neurology |
| title | Transcranial pulse stimulation in the treatment of mild neurocognitive disorders |
| title_full | Transcranial pulse stimulation in the treatment of mild neurocognitive disorders |
| title_fullStr | Transcranial pulse stimulation in the treatment of mild neurocognitive disorders |
| title_full_unstemmed | Transcranial pulse stimulation in the treatment of mild neurocognitive disorders |
| title_short | Transcranial pulse stimulation in the treatment of mild neurocognitive disorders |
| title_sort | transcranial pulse stimulation in the treatment of mild neurocognitive disorders |
| url | https://doi.org/10.1002/acn3.51882 |
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