Decreased Plasma Hydrogen Sulfide Level Is Associated With the Severity of Depression in Patients With Depressive Disorder
Accumulating evidence has suggested a dysfunction of synaptic plasticity in the pathophysiology of depression. Hydrogen sulfide (H2S), an endogenous gasotransmitter that regulates synaptic plasticity, has been demonstrated to contribute to depressive-like behaviors in rodents. The current study inve...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.765664/full |
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| author | Yuan-Jian Yang Yuan-Jian Yang Yuan-Jian Yang Chun-Nuan Chen Jin-Qiong Zhan Jin-Qiong Zhan Qiao-Sheng Liu Qiao-Sheng Liu Yun Liu Shu-Zhen Jiang Bo Wei Bo Wei Bo Wei |
| author_facet | Yuan-Jian Yang Yuan-Jian Yang Yuan-Jian Yang Chun-Nuan Chen Jin-Qiong Zhan Jin-Qiong Zhan Qiao-Sheng Liu Qiao-Sheng Liu Yun Liu Shu-Zhen Jiang Bo Wei Bo Wei Bo Wei |
| author_sort | Yuan-Jian Yang |
| collection | DOAJ |
| description | Accumulating evidence has suggested a dysfunction of synaptic plasticity in the pathophysiology of depression. Hydrogen sulfide (H2S), an endogenous gasotransmitter that regulates synaptic plasticity, has been demonstrated to contribute to depressive-like behaviors in rodents. The current study investigated the relationship between plasma H2S levels and the depressive symptoms in patients with depression. Forty-seven depressed patients and 51 healthy individuals were recruited in this study. The 17-item Hamilton Depression Rating Scale (HAMD-17) was used to evaluate depressive symptoms for all subjects and the reversed-phase high-performance liquid chromatography (RP-HPLC) was used to measure plasmaH2S levels. We found that plasma H2S levels were significantly lower in patients with depression relative to healthy individuals (P < 0.001). Compared with healthy controls (1.02 ± 0.34 μmol/L), the plasma H2S level significantly decreased in patients with mild depression (0.84 ± 0.28 μmol/L), with moderate depression (0.62 ± 0.21μmol/L), and with severe depression (0.38 ± 0.18 μmol/L). Correlation analysis revealed that plasma H2S levels were significantly negatively correlated with the HAMD-17 scores in patients (r = −0.484, P = 0.001). Multivariate linear regression analysis showed that plasma H2S was an independent contributor to the HAMD-17 score in patients (B = −0.360, t = −2.550, P = 0.015). Collectively, these results suggest that decreased H2S is involved in the pathophysiology of depression, and plasma H2S might be a potential indicator for depression severity. |
| first_indexed | 2024-12-19T03:06:16Z |
| format | Article |
| id | doaj.art-7d7181367e2849dc821c8879106edddd |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-19T03:06:16Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-7d7181367e2849dc821c8879106edddd2022-12-21T20:38:06ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402021-11-011210.3389/fpsyt.2021.765664765664Decreased Plasma Hydrogen Sulfide Level Is Associated With the Severity of Depression in Patients With Depressive DisorderYuan-Jian Yang0Yuan-Jian Yang1Yuan-Jian Yang2Chun-Nuan Chen3Jin-Qiong Zhan4Jin-Qiong Zhan5Qiao-Sheng Liu6Qiao-Sheng Liu7Yun Liu8Shu-Zhen Jiang9Bo Wei10Bo Wei11Bo Wei12Biological Psychiatry Laboratory, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Nanchang, ChinaDepartment of Psychiatry, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Nanchang, ChinaJiangxi Provincial Clinical Research Center on Mental Disorders, Nanchang, ChinaDepartment of Neurology, The Second Clinical Medical College, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, ChinaBiological Psychiatry Laboratory, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Nanchang, ChinaJiangxi Provincial Clinical Research Center on Mental Disorders, Nanchang, ChinaDepartment of Psychiatry, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Nanchang, ChinaJiangxi Provincial Clinical Research Center on Mental Disorders, Nanchang, ChinaDepartment of Psychiatry, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Nanchang, ChinaBiological Psychiatry Laboratory, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Nanchang, ChinaBiological Psychiatry Laboratory, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Nanchang, ChinaDepartment of Psychiatry, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Nanchang, ChinaJiangxi Provincial Clinical Research Center on Mental Disorders, Nanchang, ChinaAccumulating evidence has suggested a dysfunction of synaptic plasticity in the pathophysiology of depression. Hydrogen sulfide (H2S), an endogenous gasotransmitter that regulates synaptic plasticity, has been demonstrated to contribute to depressive-like behaviors in rodents. The current study investigated the relationship between plasma H2S levels and the depressive symptoms in patients with depression. Forty-seven depressed patients and 51 healthy individuals were recruited in this study. The 17-item Hamilton Depression Rating Scale (HAMD-17) was used to evaluate depressive symptoms for all subjects and the reversed-phase high-performance liquid chromatography (RP-HPLC) was used to measure plasmaH2S levels. We found that plasma H2S levels were significantly lower in patients with depression relative to healthy individuals (P < 0.001). Compared with healthy controls (1.02 ± 0.34 μmol/L), the plasma H2S level significantly decreased in patients with mild depression (0.84 ± 0.28 μmol/L), with moderate depression (0.62 ± 0.21μmol/L), and with severe depression (0.38 ± 0.18 μmol/L). Correlation analysis revealed that plasma H2S levels were significantly negatively correlated with the HAMD-17 scores in patients (r = −0.484, P = 0.001). Multivariate linear regression analysis showed that plasma H2S was an independent contributor to the HAMD-17 score in patients (B = −0.360, t = −2.550, P = 0.015). Collectively, these results suggest that decreased H2S is involved in the pathophysiology of depression, and plasma H2S might be a potential indicator for depression severity.https://www.frontiersin.org/articles/10.3389/fpsyt.2021.765664/fulldepressionhydrogen sulfide (H2S)plasmaseveritycorrelation |
| spellingShingle | Yuan-Jian Yang Yuan-Jian Yang Yuan-Jian Yang Chun-Nuan Chen Jin-Qiong Zhan Jin-Qiong Zhan Qiao-Sheng Liu Qiao-Sheng Liu Yun Liu Shu-Zhen Jiang Bo Wei Bo Wei Bo Wei Decreased Plasma Hydrogen Sulfide Level Is Associated With the Severity of Depression in Patients With Depressive Disorder Frontiers in Psychiatry depression hydrogen sulfide (H2S) plasma severity correlation |
| title | Decreased Plasma Hydrogen Sulfide Level Is Associated With the Severity of Depression in Patients With Depressive Disorder |
| title_full | Decreased Plasma Hydrogen Sulfide Level Is Associated With the Severity of Depression in Patients With Depressive Disorder |
| title_fullStr | Decreased Plasma Hydrogen Sulfide Level Is Associated With the Severity of Depression in Patients With Depressive Disorder |
| title_full_unstemmed | Decreased Plasma Hydrogen Sulfide Level Is Associated With the Severity of Depression in Patients With Depressive Disorder |
| title_short | Decreased Plasma Hydrogen Sulfide Level Is Associated With the Severity of Depression in Patients With Depressive Disorder |
| title_sort | decreased plasma hydrogen sulfide level is associated with the severity of depression in patients with depressive disorder |
| topic | depression hydrogen sulfide (H2S) plasma severity correlation |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.765664/full |
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