A disease‐associated missense mutation in CYP4F3 affects the metabolism of leukotriene B4 via disruption of electron transfer

A disease‐associated missense mutation in CYP4F3 affects the metabolism of leukotriene B4 via disruption of electron transfer

Abstract Background Cytochrome P450 4F3 (CYP4F3) is an ω‐hydroxylase that oxidizes leukotriene B4 (LTB4), prostaglandins, and fatty acid epoxides. LTB4 is synthesized by leukocytes and acts as a chemoattractant for neutrophils, making it an essential component of the innate immune system. Recently,...

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Bibliographic Details
Main Authors: Elien Smeets, Shengyun Huang, Xiao Yin Lee, Erika Van Nieuwenhove, Christine Helsen, Florian Handle, Lisa Moris, Sarah El Kharraz, Roy Eerlings, Wout Devlies, Mathijs Willemsen, Leoni Bücken, Teresa Prezzemolo, Stephanie Humblet‐Baron, Arnout Voet, Anne Rochtus, Ann Van Schepdael, Francis deZegher, Frank Claessens
Format: Article
Language:English
Published: Wiley 2022-08-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
CYP4F3
LTB4
POR
Cytb5
Exhaustion
Muscle weakness
Online Access:https://doi.org/10.1002/jcsm.13022

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