Pharmacological and clinical feature of rebamipide: new therapeutic targets
Rebamipide is a cytoprotector developed in Japan where it has been successfully used for the treatment of stomach diseases for 30 years. Initially discovered effects of the drug included the induction of prostaglandins and the elimination of free oxygen radicals. Recent studies discovered new therap...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2020-02-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/viewFile/33918/pdf |
| _version_ | 1818617420579864576 |
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| author | M. Yu. Zvyaglova O. V. Knyazev A. I. Parfenov |
| author_facet | M. Yu. Zvyaglova O. V. Knyazev A. I. Parfenov |
| author_sort | M. Yu. Zvyaglova |
| collection | DOAJ |
| description | Rebamipide is a cytoprotector developed in Japan where it has been successfully used for the treatment of stomach diseases for 30 years. Initially discovered effects of the drug included the induction of prostaglandins and the elimination of free oxygen radicals. Recent studies discovered new therapeutic targets of the drug, its new forms that made possible using rebamipid for the treatment of such diseases as NSAID enteropathy, ulcerative colitis, radiation colitis, pouchitis, enteropathy with impaired membrane digestion. It is used in endoscopy, ophthalmology, chemotherapy, rheumatology. The aim of this review is to present current information about the pharmacological and clinical feature of rebamipide and to study its therapeutic potential. |
| first_indexed | 2024-12-16T17:05:25Z |
| format | Article |
| id | doaj.art-7d742ee1631244bba86b71c6445099c9 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-16T17:05:25Z |
| publishDate | 2020-02-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-7d742ee1631244bba86b71c6445099c92022-12-21T22:23:35Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422020-02-0192210411110.26442/00403660.2020.02.00056930605Pharmacological and clinical feature of rebamipide: new therapeutic targetsM. Yu. Zvyaglova0O. V. Knyazev1A. I. Parfenov2Loginov Moscow Clinical Research CenterLoginov Moscow Clinical Research CenterLoginov Moscow Clinical Research CenterRebamipide is a cytoprotector developed in Japan where it has been successfully used for the treatment of stomach diseases for 30 years. Initially discovered effects of the drug included the induction of prostaglandins and the elimination of free oxygen radicals. Recent studies discovered new therapeutic targets of the drug, its new forms that made possible using rebamipid for the treatment of such diseases as NSAID enteropathy, ulcerative colitis, radiation colitis, pouchitis, enteropathy with impaired membrane digestion. It is used in endoscopy, ophthalmology, chemotherapy, rheumatology. The aim of this review is to present current information about the pharmacological and clinical feature of rebamipide and to study its therapeutic potential.https://ter-arkhiv.ru/0040-3660/article/viewFile/33918/pdfrebamipidecytoprotectorenteropathydisaccharidasespeptic ulcer diseaseulcerative colitisradiation colitisoral mucositisdry eye syndrome |
| spellingShingle | M. Yu. Zvyaglova O. V. Knyazev A. I. Parfenov Pharmacological and clinical feature of rebamipide: new therapeutic targets Терапевтический архив rebamipide cytoprotector enteropathy disaccharidases peptic ulcer disease ulcerative colitis radiation colitis oral mucositis dry eye syndrome |
| title | Pharmacological and clinical feature of rebamipide: new therapeutic targets |
| title_full | Pharmacological and clinical feature of rebamipide: new therapeutic targets |
| title_fullStr | Pharmacological and clinical feature of rebamipide: new therapeutic targets |
| title_full_unstemmed | Pharmacological and clinical feature of rebamipide: new therapeutic targets |
| title_short | Pharmacological and clinical feature of rebamipide: new therapeutic targets |
| title_sort | pharmacological and clinical feature of rebamipide new therapeutic targets |
| topic | rebamipide cytoprotector enteropathy disaccharidases peptic ulcer disease ulcerative colitis radiation colitis oral mucositis dry eye syndrome |
| url | https://ter-arkhiv.ru/0040-3660/article/viewFile/33918/pdf |
| work_keys_str_mv | AT myuzvyaglova pharmacologicalandclinicalfeatureofrebamipidenewtherapeutictargets AT ovknyazev pharmacologicalandclinicalfeatureofrebamipidenewtherapeutictargets AT aiparfenov pharmacologicalandclinicalfeatureofrebamipidenewtherapeutictargets |