COVID-19 and iron deficiency anemia: relationships of pathogenesis and therapy
During pregnancy, a woman becomes more susceptible to respiratory and viral diseases, including novel coronavirus infection (COVID-19). Pregnancy exacerbates the acute inflammation typical to COVID-19, elevating a risk of developing cytokine storm, characterized by an avalanche-like spike of inflamm...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2020-11-01
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| Series: | Акушерство, гинекология и репродукция |
| Subjects: | |
| Online Access: | https://www.gynecology.su/jour/article/view/831 |
| _version_ | 1797884068581343232 |
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| author | O. A. Gromova I. Yu. Torshin Yu. O. Shapovalova M. A. Kurtser A. G. Chuchalin |
| author_facet | O. A. Gromova I. Yu. Torshin Yu. O. Shapovalova M. A. Kurtser A. G. Chuchalin |
| author_sort | O. A. Gromova |
| collection | DOAJ |
| description | During pregnancy, a woman becomes more susceptible to respiratory and viral diseases, including novel coronavirus infection (COVID-19). Pregnancy exacerbates the acute inflammation typical to COVID-19, elevating a risk of developing cytokine storm, characterized by an avalanche-like spike of inflammation marker concentrations (C-reactive protein, interleukin-1 в, interleukin-6, interferon-Y, ferritin, erythrocyte sedimentation rate etc.). Cytokine storm increases a risk of pregnancy loss and contribute to formation of multiple organ dysfunction syndrome in pregnant women and fetus. In particular, erythrocyte degradation due to acute inflammation leads to hypoxia and uncontrolled inter-tissue iron redistribution. As a result, conditions are created simultaneously for developing pulmonary hemosiderosis and hemosiderosis of other tissues in pregnant woman and fetus, as well as for augmenting iron loss from the body, which exacerbates iron deficiency anemia (IDA). It is important to emphasize that a surge of ferritin level distinctive for severe COVID-19, does not indicate iron overload. Therefore, recommendations to cancel IDA correction and even to use iron chelators in COVID-19 may increase hypoxia and harm the health of pregnant women. |
| first_indexed | 2024-04-10T04:01:43Z |
| format | Article |
| id | doaj.art-7d76eedc5ec143d18d2948ff1720f296 |
| institution | Directory Open Access Journal |
| issn | 2313-7347 2500-3194 |
| language | Russian |
| last_indexed | 2024-04-10T04:01:43Z |
| publishDate | 2020-11-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Акушерство, гинекология и репродукция |
| spelling | doaj.art-7d76eedc5ec143d18d2948ff1720f2962023-03-13T07:09:51ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942020-11-0114564465510.17749/2313-7347/ob.gyn.rep.2020.179596COVID-19 and iron deficiency anemia: relationships of pathogenesis and therapyO. A. Gromova0I. Yu. Torshin1Yu. O. Shapovalova2M. A. Kurtser3A. G. Chuchalin4Institute of Pharmacoinformatics, Federal Research Center «Informatics and Management», Russian Academy of Sciences; Big Data Storage and Analysis Center, Lomonosov Moscow State UniversityInstitute of Pharmacoinformatics, Federal Research Center «Informatics and Management», Russian Academy of Sciences; Big Data Storage and Analysis Center, Lomonosov Moscow State UniversityLapino Clinic Hospital, MD Medical GroupPirogov Russian National Research Medical University, Health Ministry of Russian FederationPirogov Russian National Research Medical University, Health Ministry of Russian FederationDuring pregnancy, a woman becomes more susceptible to respiratory and viral diseases, including novel coronavirus infection (COVID-19). Pregnancy exacerbates the acute inflammation typical to COVID-19, elevating a risk of developing cytokine storm, characterized by an avalanche-like spike of inflammation marker concentrations (C-reactive protein, interleukin-1 в, interleukin-6, interferon-Y, ferritin, erythrocyte sedimentation rate etc.). Cytokine storm increases a risk of pregnancy loss and contribute to formation of multiple organ dysfunction syndrome in pregnant women and fetus. In particular, erythrocyte degradation due to acute inflammation leads to hypoxia and uncontrolled inter-tissue iron redistribution. As a result, conditions are created simultaneously for developing pulmonary hemosiderosis and hemosiderosis of other tissues in pregnant woman and fetus, as well as for augmenting iron loss from the body, which exacerbates iron deficiency anemia (IDA). It is important to emphasize that a surge of ferritin level distinctive for severe COVID-19, does not indicate iron overload. Therefore, recommendations to cancel IDA correction and even to use iron chelators in COVID-19 may increase hypoxia and harm the health of pregnant women.https://www.gynecology.su/jour/article/view/831pregnancyferritiniron homeostasisanemiacovid-19 |
| spellingShingle | O. A. Gromova I. Yu. Torshin Yu. O. Shapovalova M. A. Kurtser A. G. Chuchalin COVID-19 and iron deficiency anemia: relationships of pathogenesis and therapy Акушерство, гинекология и репродукция pregnancy ferritin iron homeostasis anemia covid-19 |
| title | COVID-19 and iron deficiency anemia: relationships of pathogenesis and therapy |
| title_full | COVID-19 and iron deficiency anemia: relationships of pathogenesis and therapy |
| title_fullStr | COVID-19 and iron deficiency anemia: relationships of pathogenesis and therapy |
| title_full_unstemmed | COVID-19 and iron deficiency anemia: relationships of pathogenesis and therapy |
| title_short | COVID-19 and iron deficiency anemia: relationships of pathogenesis and therapy |
| title_sort | covid 19 and iron deficiency anemia relationships of pathogenesis and therapy |
| topic | pregnancy ferritin iron homeostasis anemia covid-19 |
| url | https://www.gynecology.su/jour/article/view/831 |
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