Widely Targeted Metabolomics Analysis of Soybean and Chickpea and Their Different Advantages and New Functional Compounds for Diabetes
Soybean is widely used as a kind of bean for daily consumption. Chickpea is increasingly utilised because of its good healthcare function. At present, using chickpeas could have better results than soybeans in some areas. Previous studies of the two legumes focused on certain components and failed t...
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MDPI AG
2022-08-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/16/5297 |
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| author | Pengshou Li Yumiao Bian Mengdan Li Lingmei Li Baosheng Zhao Qixiang Ma Yingchun Song Jiuyi Li Gangsheng Chen |
| author_facet | Pengshou Li Yumiao Bian Mengdan Li Lingmei Li Baosheng Zhao Qixiang Ma Yingchun Song Jiuyi Li Gangsheng Chen |
| author_sort | Pengshou Li |
| collection | DOAJ |
| description | Soybean is widely used as a kind of bean for daily consumption. Chickpea is increasingly utilised because of its good healthcare function. At present, using chickpeas could have better results than soybeans in some areas. Previous studies of the two legumes focused on certain components and failed to fully reveal the differences between the two legumes. Thus, understanding the comprehensive similarities and differences between the two legumes is necessary to apply and develop these legumes effectively. In this study, we performed a UPLC-ESI-MS/MS-based widely targeted metabolomics analysis on two legumes. A total of 776 metabolites (including primary metabolites and secondary metabolites) were detected, which were divided into more than a dozen broad categories. The differential analysis of these metabolites showed that there were 480 metabolites with significant differences in relative contents between the two legumes. Compared with soybean, the expression of 374 metabolites of chickpea was down-regulated and that of 106 metabolites was up-regulated. The metabolic pathway analysis showed significant differences in the flavonoids biosynthesis, phenylpropanoid biosynthesis, linoleic acid metabolism and alkaloid biosynthesis between the two legumes. The advantages and applicability of the two kinds of legumes were confirmed through the analysis of anti-diabetic components. Moreover, some novel compounds (with contents higher than that of soybean) with hypoglycaemic activity were found in chickpea. This study provides an important reference for the in-depth study and comparative application of soybean and chickpea. |
| first_indexed | 2024-03-09T04:01:35Z |
| format | Article |
| id | doaj.art-7d77801473784ea6a3338486eeb36407 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T04:01:35Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-7d77801473784ea6a3338486eeb364072023-12-03T14:12:06ZengMDPI AGMolecules1420-30492022-08-012716529710.3390/molecules27165297Widely Targeted Metabolomics Analysis of Soybean and Chickpea and Their Different Advantages and New Functional Compounds for DiabetesPengshou Li0Yumiao Bian1Mengdan Li2Lingmei Li3Baosheng Zhao4Qixiang Ma5Yingchun Song6Jiuyi Li7Gangsheng Chen8School of Food and Drug, Luoyang Normal University, Luoyang 471934, ChinaSchool of Food and Drug, Luoyang Normal University, Luoyang 471934, ChinaSchool of Food and Drug, Luoyang Normal University, Luoyang 471934, ChinaSchool of Food and Drug, Luoyang Normal University, Luoyang 471934, ChinaBeijing Academy of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, ChinaCancer Institute, Fudan University Cancer Hospital and Cancer Metabolism Laboratory, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, ChinaSchool of Food and Drug, Luoyang Normal University, Luoyang 471934, ChinaSchool of Food and Drug, Luoyang Normal University, Luoyang 471934, ChinaSchool of Food and Drug, Luoyang Normal University, Luoyang 471934, ChinaSoybean is widely used as a kind of bean for daily consumption. Chickpea is increasingly utilised because of its good healthcare function. At present, using chickpeas could have better results than soybeans in some areas. Previous studies of the two legumes focused on certain components and failed to fully reveal the differences between the two legumes. Thus, understanding the comprehensive similarities and differences between the two legumes is necessary to apply and develop these legumes effectively. In this study, we performed a UPLC-ESI-MS/MS-based widely targeted metabolomics analysis on two legumes. A total of 776 metabolites (including primary metabolites and secondary metabolites) were detected, which were divided into more than a dozen broad categories. The differential analysis of these metabolites showed that there were 480 metabolites with significant differences in relative contents between the two legumes. Compared with soybean, the expression of 374 metabolites of chickpea was down-regulated and that of 106 metabolites was up-regulated. The metabolic pathway analysis showed significant differences in the flavonoids biosynthesis, phenylpropanoid biosynthesis, linoleic acid metabolism and alkaloid biosynthesis between the two legumes. The advantages and applicability of the two kinds of legumes were confirmed through the analysis of anti-diabetic components. Moreover, some novel compounds (with contents higher than that of soybean) with hypoglycaemic activity were found in chickpea. This study provides an important reference for the in-depth study and comparative application of soybean and chickpea.https://www.mdpi.com/1420-3049/27/16/5297chickpeasoybeanwidely targeted metabolomicsdifferential metabolitesdiabetes |
| spellingShingle | Pengshou Li Yumiao Bian Mengdan Li Lingmei Li Baosheng Zhao Qixiang Ma Yingchun Song Jiuyi Li Gangsheng Chen Widely Targeted Metabolomics Analysis of Soybean and Chickpea and Their Different Advantages and New Functional Compounds for Diabetes Molecules chickpea soybean widely targeted metabolomics differential metabolites diabetes |
| title | Widely Targeted Metabolomics Analysis of Soybean and Chickpea and Their Different Advantages and New Functional Compounds for Diabetes |
| title_full | Widely Targeted Metabolomics Analysis of Soybean and Chickpea and Their Different Advantages and New Functional Compounds for Diabetes |
| title_fullStr | Widely Targeted Metabolomics Analysis of Soybean and Chickpea and Their Different Advantages and New Functional Compounds for Diabetes |
| title_full_unstemmed | Widely Targeted Metabolomics Analysis of Soybean and Chickpea and Their Different Advantages and New Functional Compounds for Diabetes |
| title_short | Widely Targeted Metabolomics Analysis of Soybean and Chickpea and Their Different Advantages and New Functional Compounds for Diabetes |
| title_sort | widely targeted metabolomics analysis of soybean and chickpea and their different advantages and new functional compounds for diabetes |
| topic | chickpea soybean widely targeted metabolomics differential metabolites diabetes |
| url | https://www.mdpi.com/1420-3049/27/16/5297 |
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