Neuronal and Non-Neuronal GABA in COVID-19: Relevance for Psychiatry
Infection with SARS-CoV-2, the causative agent of the COVID-19 pandemic, originated in China and quickly spread across the globe. Despite tremendous economic and healthcare devastation, research on this virus has contributed to a better understanding of numerous molecular pathways, including those i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Reports |
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| Online Access: | https://www.mdpi.com/2571-841X/5/2/22 |
| _version_ | 1797482610172100608 |
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| author | Adonis Sfera Karina G. Thomas Sarvin Sasannia Jonathan J. Anton Christina V. Andronescu Michael Garcia Dan O. Sfera Michael A. Cummings Zisis Kozlakidis |
| author_facet | Adonis Sfera Karina G. Thomas Sarvin Sasannia Jonathan J. Anton Christina V. Andronescu Michael Garcia Dan O. Sfera Michael A. Cummings Zisis Kozlakidis |
| author_sort | Adonis Sfera |
| collection | DOAJ |
| description | Infection with SARS-CoV-2, the causative agent of the COVID-19 pandemic, originated in China and quickly spread across the globe. Despite tremendous economic and healthcare devastation, research on this virus has contributed to a better understanding of numerous molecular pathways, including those involving γ-aminobutyric acid (GABA), that will positively impact medical science, including neuropsychiatry, in the post-pandemic era. SARS-CoV-2 primarily enters the host cells through the renin–angiotensin system’s component named angiotensin-converting enzyme-2 (ACE-2). Among its many functions, this protein upregulates GABA, protecting not only the central nervous system but also the endothelia, the pancreas, and the gut microbiota. SARS-CoV-2 binding to ACE-2 usurps the neuronal and non-neuronal GABAergic systems, contributing to the high comorbidity of neuropsychiatric illness with gut dysbiosis and endothelial and metabolic dysfunctions. In this perspective article, we take a closer look at the pathology emerging from the viral hijacking of non-neuronal GABA and summarize potential interventions for restoring these systems. |
| first_indexed | 2024-03-09T22:35:51Z |
| format | Article |
| id | doaj.art-7d785f515e6d4192be033f1d9b8b5686 |
| institution | Directory Open Access Journal |
| issn | 2571-841X |
| language | English |
| last_indexed | 2024-03-09T22:35:51Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Reports |
| spelling | doaj.art-7d785f515e6d4192be033f1d9b8b56862023-11-23T18:49:37ZengMDPI AGReports2571-841X2022-06-01522210.3390/reports5020022Neuronal and Non-Neuronal GABA in COVID-19: Relevance for PsychiatryAdonis Sfera0Karina G. Thomas1Sarvin Sasannia2Jonathan J. Anton3Christina V. Andronescu4Michael Garcia5Dan O. Sfera6Michael A. Cummings7Zisis Kozlakidis8Patton State Hospital, University of California, Riverside, CA 92521, USAPatton State Hospital, University of California, Riverside, CA 92521, USADepartment of Medicine, Shiraz University of Medical Sciences, Shiraz 14336-71348, IranPatton State Hospital, University of California, Riverside, CA 92521, USAMedical Anthropology Department, Stanford University, Stanford, CA 94305, USADepartment of Psychiatry, University of California, Riverside, CA 92521, USAPatton State Hospital, University of California, Riverside, CA 92521, USAPatton State Hospital, University of California, Riverside, CA 92521, USAInternational Agency for Research on Cancer (IARC), 69372 Lyon, FranceInfection with SARS-CoV-2, the causative agent of the COVID-19 pandemic, originated in China and quickly spread across the globe. Despite tremendous economic and healthcare devastation, research on this virus has contributed to a better understanding of numerous molecular pathways, including those involving γ-aminobutyric acid (GABA), that will positively impact medical science, including neuropsychiatry, in the post-pandemic era. SARS-CoV-2 primarily enters the host cells through the renin–angiotensin system’s component named angiotensin-converting enzyme-2 (ACE-2). Among its many functions, this protein upregulates GABA, protecting not only the central nervous system but also the endothelia, the pancreas, and the gut microbiota. SARS-CoV-2 binding to ACE-2 usurps the neuronal and non-neuronal GABAergic systems, contributing to the high comorbidity of neuropsychiatric illness with gut dysbiosis and endothelial and metabolic dysfunctions. In this perspective article, we take a closer look at the pathology emerging from the viral hijacking of non-neuronal GABA and summarize potential interventions for restoring these systems.https://www.mdpi.com/2571-841X/5/2/22GABASARS-CoV-2renin–angiotensin systemmicrobiomeneuropsychiatric disorders |
| spellingShingle | Adonis Sfera Karina G. Thomas Sarvin Sasannia Jonathan J. Anton Christina V. Andronescu Michael Garcia Dan O. Sfera Michael A. Cummings Zisis Kozlakidis Neuronal and Non-Neuronal GABA in COVID-19: Relevance for Psychiatry Reports GABA SARS-CoV-2 renin–angiotensin system microbiome neuropsychiatric disorders |
| title | Neuronal and Non-Neuronal GABA in COVID-19: Relevance for Psychiatry |
| title_full | Neuronal and Non-Neuronal GABA in COVID-19: Relevance for Psychiatry |
| title_fullStr | Neuronal and Non-Neuronal GABA in COVID-19: Relevance for Psychiatry |
| title_full_unstemmed | Neuronal and Non-Neuronal GABA in COVID-19: Relevance for Psychiatry |
| title_short | Neuronal and Non-Neuronal GABA in COVID-19: Relevance for Psychiatry |
| title_sort | neuronal and non neuronal gaba in covid 19 relevance for psychiatry |
| topic | GABA SARS-CoV-2 renin–angiotensin system microbiome neuropsychiatric disorders |
| url | https://www.mdpi.com/2571-841X/5/2/22 |
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