Validation of a preclinical dry eye model in New Zealand white rabbits during and following topical instillation of 1% ophthalmic atropine sulfate

Validation of a preclinical dry eye model in New Zealand white rabbits during and following topical instillation of 1% ophthalmic atropine sulfate

Abstract Background The objective of this study was to validate an animal model for dry eye during and after the administration of 1% ophthalmic atropine sulfate (OAS) in New Zealand white (NZW) rabbits. Methods OAS (1%) was applied three times per day to 30 eyes of 15 healthy NZW rabbits. Sacrifice...

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Bibliographic Details
Main Authors: Alejandra Sánchez‐Ríos, Elba Yadira Correa‐Gallegos, José Manuel Medina‐Espinoza, Andrea Anaid Navarro‐Sanchez, Oscar Olvera‐Montaño, Leopoldo Baiza‐Durán, Patricia Muñoz‐Villegas
Format: Article
Language:English
Published: Wiley 2022-06-01
Series:Animal Models and Experimental Medicine
Subjects:
atropine sulfate
dry eye
rabbit model
safety
Schirmer I test
TBUT
Online Access:https://doi.org/10.1002/ame2.12218

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