eIF4G1 N-terminal intrinsically disordered domain is a multi-docking station for RNA, Pab1, Pub1, and self-assembly

eIF4G1 N-terminal intrinsically disordered domain is a multi-docking station for RNA, Pab1, Pub1, and self-assembly

Yeast eIF4G1 interacts with RNA binding proteins (RBPs) like Pab1 and Pub1 affecting its function in translation initiation and stress granules formation. We present an NMR and SAXS study of the N-terminal intrinsically disordered region of eIF4G1 (residues 1–249) and its interactions with Pub1, Pab...

Full description

Bibliographic Details
Main Authors: Belén Chaves-Arquero, Santiago Martínez-Lumbreras, Nathalie Sibille, Sergio Camero, Pau Bernadó, M. Ángeles Jiménez, Silvia Zorrilla, José Manuel Pérez-Cañadillas
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Molecular Biosciences
Subjects:
intrinsically disordered proteins (IDP)
eIF4G1
Pab1
Pub1
NMR
structural ensemble
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.986121/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.986121/full

Similar Items