The Recurrent Mutation in PATL2 Inhibits Its Degradation Thus Causing Female Infertility Characterized by Oocyte Maturation Defect Through Regulation of the Mos-MAPK Pathway

The Recurrent Mutation in PATL2 Inhibits Its Degradation Thus Causing Female Infertility Characterized by Oocyte Maturation Defect Through Regulation of the Mos-MAPK Pathway

PAT1 homolog 2 (PATL2), encoding an RNA-binding protein, is a repressor involved in the translational regulation of maternal mRNAs during oocyte maturation. Previous studies have reported mutations in PATL2 those led to female infertility with oocyte maturation arrest; however, the mechanisms by whi...

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Bibliographic Details
Main Authors: Qiqi Cao, Chun Zhao, Congjing Wang, Lingbo Cai, Meng Xia, Xiaolan Zhang, Jian Han, Yangyang Xu, Junqiang Zhang, Xiufeng Ling, Xiang Ma, Ran Huo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
meiotic maturation
PATL2 mutation
ART
MAPK
female infertility
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.628649/full

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