Preclinical Studies in Small Animals for Advanced Drug Delivery Using Hyperthermia and Intravital Microscopy
This paper presents three devices suitable for the preclinical application of hyperthermia via the simultaneous high-resolution imaging of intratumoral events. (Pre)clinical studies have confirmed that the tumor micro-environment is sensitive to the application of local mild hyperthermia. Therefore,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/20/5146 |
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| author | Marjolein I. Priester Sergio Curto Ann L. B. Seynhaeve Anderson Cruz Perdomo Mohamadreza Amin Pierre Agnass Milad Salimibani Pegah Faridi Punit Prakash Gerard C. van Rhoon Timo L. M. ten Hagen |
| author_facet | Marjolein I. Priester Sergio Curto Ann L. B. Seynhaeve Anderson Cruz Perdomo Mohamadreza Amin Pierre Agnass Milad Salimibani Pegah Faridi Punit Prakash Gerard C. van Rhoon Timo L. M. ten Hagen |
| author_sort | Marjolein I. Priester |
| collection | DOAJ |
| description | This paper presents three devices suitable for the preclinical application of hyperthermia via the simultaneous high-resolution imaging of intratumoral events. (Pre)clinical studies have confirmed that the tumor micro-environment is sensitive to the application of local mild hyperthermia. Therefore, heating is a promising adjuvant to aid the efficacy of radiotherapy or chemotherapy. More so, the application of mild hyperthermia is a useful stimulus for triggered drug release from heat-sensitive nanocarriers. The response of thermosensitive nanoparticles to hyperthermia and ensuing intratumoral kinetics are considerably complex in both space and time. To obtain better insight into intratumoral processes, longitudinal imaging (preferable in high spatial and temporal resolution) is highly informative. Our devices are based on (i) an external electric heating adaptor for the dorsal skinfold model, (ii) targeted radiofrequency application, and (iii) a microwave antenna for heating of internal tumors. These models, while of some technical complexity, significantly add to the understanding of effects of mild hyperthermia warranting implementation in research on hyperthermia. |
| first_indexed | 2024-03-10T06:40:31Z |
| format | Article |
| id | doaj.art-7d79d4df9c064e4f8db7a387287c9ee7 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T06:40:31Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-7d79d4df9c064e4f8db7a387287c9ee72023-11-22T17:41:02ZengMDPI AGCancers2072-66942021-10-011320514610.3390/cancers13205146Preclinical Studies in Small Animals for Advanced Drug Delivery Using Hyperthermia and Intravital MicroscopyMarjolein I. Priester0Sergio Curto1Ann L. B. Seynhaeve2Anderson Cruz Perdomo3Mohamadreza Amin4Pierre Agnass5Milad Salimibani6Pegah Faridi7Punit Prakash8Gerard C. van Rhoon9Timo L. M. ten Hagen10Laboratory Experimental Oncology (LEO), Department of Pathology, Erasmus University Medical Center, 3015 GD Rotterdam, The NetherlandsDepartment of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center Rotterdam, 3015 GD Rotterdam, The NetherlandsLaboratory Experimental Oncology (LEO), Department of Pathology, Erasmus University Medical Center, 3015 GD Rotterdam, The NetherlandsDepartment of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center Rotterdam, 3015 GD Rotterdam, The NetherlandsLaboratory Experimental Oncology (LEO), Department of Pathology, Erasmus University Medical Center, 3015 GD Rotterdam, The NetherlandsDepartment of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center Rotterdam, 3015 GD Rotterdam, The NetherlandsDepartment of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center Rotterdam, 3015 GD Rotterdam, The NetherlandsDepartment of Electrical and Computer Engineering, Kansas State University, Manhattan, KS 66506, USADepartment of Electrical and Computer Engineering, Kansas State University, Manhattan, KS 66506, USADepartment of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center Rotterdam, 3015 GD Rotterdam, The NetherlandsLaboratory Experimental Oncology (LEO), Department of Pathology, Erasmus University Medical Center, 3015 GD Rotterdam, The NetherlandsThis paper presents three devices suitable for the preclinical application of hyperthermia via the simultaneous high-resolution imaging of intratumoral events. (Pre)clinical studies have confirmed that the tumor micro-environment is sensitive to the application of local mild hyperthermia. Therefore, heating is a promising adjuvant to aid the efficacy of radiotherapy or chemotherapy. More so, the application of mild hyperthermia is a useful stimulus for triggered drug release from heat-sensitive nanocarriers. The response of thermosensitive nanoparticles to hyperthermia and ensuing intratumoral kinetics are considerably complex in both space and time. To obtain better insight into intratumoral processes, longitudinal imaging (preferable in high spatial and temporal resolution) is highly informative. Our devices are based on (i) an external electric heating adaptor for the dorsal skinfold model, (ii) targeted radiofrequency application, and (iii) a microwave antenna for heating of internal tumors. These models, while of some technical complexity, significantly add to the understanding of effects of mild hyperthermia warranting implementation in research on hyperthermia.https://www.mdpi.com/2072-6694/13/20/5146hyperthermiapreclinical hyperthermiasmall animalsmultimodal therapyoptical monitoringdorsal skinfold chamber |
| spellingShingle | Marjolein I. Priester Sergio Curto Ann L. B. Seynhaeve Anderson Cruz Perdomo Mohamadreza Amin Pierre Agnass Milad Salimibani Pegah Faridi Punit Prakash Gerard C. van Rhoon Timo L. M. ten Hagen Preclinical Studies in Small Animals for Advanced Drug Delivery Using Hyperthermia and Intravital Microscopy Cancers hyperthermia preclinical hyperthermia small animals multimodal therapy optical monitoring dorsal skinfold chamber |
| title | Preclinical Studies in Small Animals for Advanced Drug Delivery Using Hyperthermia and Intravital Microscopy |
| title_full | Preclinical Studies in Small Animals for Advanced Drug Delivery Using Hyperthermia and Intravital Microscopy |
| title_fullStr | Preclinical Studies in Small Animals for Advanced Drug Delivery Using Hyperthermia and Intravital Microscopy |
| title_full_unstemmed | Preclinical Studies in Small Animals for Advanced Drug Delivery Using Hyperthermia and Intravital Microscopy |
| title_short | Preclinical Studies in Small Animals for Advanced Drug Delivery Using Hyperthermia and Intravital Microscopy |
| title_sort | preclinical studies in small animals for advanced drug delivery using hyperthermia and intravital microscopy |
| topic | hyperthermia preclinical hyperthermia small animals multimodal therapy optical monitoring dorsal skinfold chamber |
| url | https://www.mdpi.com/2072-6694/13/20/5146 |
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