Tapered Optical Fiber Sensor for Label-Free Detection of Biomolecules
This paper presents a fast, highly sensitive and low-cost tapered optical fiber biosensor that enables the label-free detection of biomolecules. The sensor takes advantage of the interference effect between the fiber’s first two propagation modes along the taper waist region. The biomolecules bonded...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-03-01
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| Series: | Sensors |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1424-8220/11/4/3780/ |
| _version_ | 1798038386249826304 |
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| author | Xingwei Wang Nan Wu Xiaotian Zou Wenhui Wang Ye Tian |
| author_facet | Xingwei Wang Nan Wu Xiaotian Zou Wenhui Wang Ye Tian |
| author_sort | Xingwei Wang |
| collection | DOAJ |
| description | This paper presents a fast, highly sensitive and low-cost tapered optical fiber biosensor that enables the label-free detection of biomolecules. The sensor takes advantage of the interference effect between the fiber’s first two propagation modes along the taper waist region. The biomolecules bonded on the taper surface were determined by demodulating the transmission spectrum phase shift. Because of the sharp spectrum fringe signals, as well as a relatively long biomolecule testing region, the sensor displayed a fast response and was highly sensitive. To better understand the influence of various biomolecules on the sensor, a numerical simulation that varied biolayer parameters such as thickness and refractive index was performed. The results showed that the spectrum fringe shift was obvious to be measured even when the biolayer was only nanometers thick. A microchannel chip was designed and fabricated for the protection of the sensor and biotesting. Microelectromechanical systems (MEMS) fabrication techniques were used to precisely control the profile and depth of the microchannel on the silicon chip with an accuracy of 2 μm. A tapered optical fiber biosensor was fabricated and evaluated with an Immune globulin G (IgG) antibody-antigen pair. |
| first_indexed | 2024-04-11T21:39:30Z |
| format | Article |
| id | doaj.art-7d7a1dd01423490dbdca2016431f8fdb |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-11T21:39:30Z |
| publishDate | 2011-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-7d7a1dd01423490dbdca2016431f8fdb2022-12-22T04:01:39ZengMDPI AGSensors1424-82202011-03-011143780379010.3390/s110403780Tapered Optical Fiber Sensor for Label-Free Detection of BiomoleculesXingwei WangNan WuXiaotian ZouWenhui WangYe TianThis paper presents a fast, highly sensitive and low-cost tapered optical fiber biosensor that enables the label-free detection of biomolecules. The sensor takes advantage of the interference effect between the fiber’s first two propagation modes along the taper waist region. The biomolecules bonded on the taper surface were determined by demodulating the transmission spectrum phase shift. Because of the sharp spectrum fringe signals, as well as a relatively long biomolecule testing region, the sensor displayed a fast response and was highly sensitive. To better understand the influence of various biomolecules on the sensor, a numerical simulation that varied biolayer parameters such as thickness and refractive index was performed. The results showed that the spectrum fringe shift was obvious to be measured even when the biolayer was only nanometers thick. A microchannel chip was designed and fabricated for the protection of the sensor and biotesting. Microelectromechanical systems (MEMS) fabrication techniques were used to precisely control the profile and depth of the microchannel on the silicon chip with an accuracy of 2 μm. A tapered optical fiber biosensor was fabricated and evaluated with an Immune globulin G (IgG) antibody-antigen pair.http://www.mdpi.com/1424-8220/11/4/3780/optical fiber sensorbiosensorlabel-free detectionevanescent waveMEMS |
| spellingShingle | Xingwei Wang Nan Wu Xiaotian Zou Wenhui Wang Ye Tian Tapered Optical Fiber Sensor for Label-Free Detection of Biomolecules Sensors optical fiber sensor biosensor label-free detection evanescent wave MEMS |
| title | Tapered Optical Fiber Sensor for Label-Free Detection of Biomolecules |
| title_full | Tapered Optical Fiber Sensor for Label-Free Detection of Biomolecules |
| title_fullStr | Tapered Optical Fiber Sensor for Label-Free Detection of Biomolecules |
| title_full_unstemmed | Tapered Optical Fiber Sensor for Label-Free Detection of Biomolecules |
| title_short | Tapered Optical Fiber Sensor for Label-Free Detection of Biomolecules |
| title_sort | tapered optical fiber sensor for label free detection of biomolecules |
| topic | optical fiber sensor biosensor label-free detection evanescent wave MEMS |
| url | http://www.mdpi.com/1424-8220/11/4/3780/ |
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