A study of application effects of next-generation sequencing based preimplantation genetic testing for aneuploidies in advanced maternal age women
Objective: To investigate if next-generation sequencing-based preimplantation genetic testing for aneuploidies could improve pregnancy outcomes in women of advanced maternal age. Materials and methods: A retrospective analysis. The clinical data of 1099 couples treated in the First Medical Center of...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Taiwanese Journal of Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1028455923001894 |
| _version_ | 1797690934067986432 |
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| author | Yizhuo Yang Xinmeng Guo Ming Zhang Hui Wang Sha Mu Hongmei Peng Yuanqing Yao |
| author_facet | Yizhuo Yang Xinmeng Guo Ming Zhang Hui Wang Sha Mu Hongmei Peng Yuanqing Yao |
| author_sort | Yizhuo Yang |
| collection | DOAJ |
| description | Objective: To investigate if next-generation sequencing-based preimplantation genetic testing for aneuploidies could improve pregnancy outcomes in women of advanced maternal age. Materials and methods: A retrospective analysis. The clinical data of 1099 couples treated in the First Medical Center of the Chinese PLA General Hospital from January 2019 to December 2021 were analyzed. They were divided into two groups based on whether they underwent a Next-generation sequencing-based preimplantation genetic test for aneuploidies. We analyzed and compared the biochemical pregnancy rate, clinical pregnancy rate, abortion rate, and live birth rate between the two groups. Results: The Preimplantation genetic testing for aneuploidies (PGT-A) group was associated with higher rate of biochemical pregnancy and clinical pregnancy than the non-PGT-A group, which were 63.9% vs. 56.4% (P = 0.009) and 54.4% vs. 45.6% (P < 0.001), respectively. The abortion rate was significantly lower in the PGT-A group compared to the non-PGT-A group (2.3% vs. 14.7%, P < 0.001). In addition, the live birth rate was significantly higher in the PGT-A group compared to the non-PGT-A group (52.1% and 30.9%, respectively, P < 0.001). Conclusion: Next-generation sequencing-based preimplantation genetic testing for aneuploidies significantly improved the pregnancy outcomes in women of advanced maternal age. |
| first_indexed | 2024-03-12T02:07:16Z |
| format | Article |
| id | doaj.art-7d7a527c929f498385a09dc7c8d389ff |
| institution | Directory Open Access Journal |
| issn | 1028-4559 |
| language | English |
| last_indexed | 2024-03-12T02:07:16Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Taiwanese Journal of Obstetrics & Gynecology |
| spelling | doaj.art-7d7a527c929f498385a09dc7c8d389ff2023-09-07T04:43:05ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592023-09-01625729734A study of application effects of next-generation sequencing based preimplantation genetic testing for aneuploidies in advanced maternal age womenYizhuo Yang0Xinmeng Guo1Ming Zhang2Hui Wang3Sha Mu4Hongmei Peng5Yuanqing Yao6Department of Obstetrics and Gynecology, The First Medical Center of Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, ChinaCollege of Medicine, Nankai University, 94 Weijin Road, Tianjin, 300071, ChinaDepartment of Obstetrics and Gynecology, The First Medical Center of Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, ChinaDepartment of Obstetrics and Gynecology, The First Medical Center of Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, ChinaDepartment of Obstetrics and Gynecology, The First Medical Center of Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, ChinaDepartment of Obstetrics and Gynecology, The First Medical Center of Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China; Corresponding author.Department of Obstetrics and Gynecology, The First Medical Center of Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China; College of Medicine, Nankai University, 94 Weijin Road, Tianjin, 300071, China; The University of Hong Kong - Shenzhen Hospital, 1 Haiyuan Road, Shenzhen, Guangdong, 518053, China; Corresponding author. Department of Obstetrics and Gynecology, PLA General Hospital, Medical School of Chinese PLA, 28 Fuxing Road, Beijing, 100853, China.Objective: To investigate if next-generation sequencing-based preimplantation genetic testing for aneuploidies could improve pregnancy outcomes in women of advanced maternal age. Materials and methods: A retrospective analysis. The clinical data of 1099 couples treated in the First Medical Center of the Chinese PLA General Hospital from January 2019 to December 2021 were analyzed. They were divided into two groups based on whether they underwent a Next-generation sequencing-based preimplantation genetic test for aneuploidies. We analyzed and compared the biochemical pregnancy rate, clinical pregnancy rate, abortion rate, and live birth rate between the two groups. Results: The Preimplantation genetic testing for aneuploidies (PGT-A) group was associated with higher rate of biochemical pregnancy and clinical pregnancy than the non-PGT-A group, which were 63.9% vs. 56.4% (P = 0.009) and 54.4% vs. 45.6% (P < 0.001), respectively. The abortion rate was significantly lower in the PGT-A group compared to the non-PGT-A group (2.3% vs. 14.7%, P < 0.001). In addition, the live birth rate was significantly higher in the PGT-A group compared to the non-PGT-A group (52.1% and 30.9%, respectively, P < 0.001). Conclusion: Next-generation sequencing-based preimplantation genetic testing for aneuploidies significantly improved the pregnancy outcomes in women of advanced maternal age.http://www.sciencedirect.com/science/article/pii/S1028455923001894Preimplantation genetic testing for aneuploidyNext-generation sequencingAdvanced maternal agePregnancy outcomes |
| spellingShingle | Yizhuo Yang Xinmeng Guo Ming Zhang Hui Wang Sha Mu Hongmei Peng Yuanqing Yao A study of application effects of next-generation sequencing based preimplantation genetic testing for aneuploidies in advanced maternal age women Taiwanese Journal of Obstetrics & Gynecology Preimplantation genetic testing for aneuploidy Next-generation sequencing Advanced maternal age Pregnancy outcomes |
| title | A study of application effects of next-generation sequencing based preimplantation genetic testing for aneuploidies in advanced maternal age women |
| title_full | A study of application effects of next-generation sequencing based preimplantation genetic testing for aneuploidies in advanced maternal age women |
| title_fullStr | A study of application effects of next-generation sequencing based preimplantation genetic testing for aneuploidies in advanced maternal age women |
| title_full_unstemmed | A study of application effects of next-generation sequencing based preimplantation genetic testing for aneuploidies in advanced maternal age women |
| title_short | A study of application effects of next-generation sequencing based preimplantation genetic testing for aneuploidies in advanced maternal age women |
| title_sort | study of application effects of next generation sequencing based preimplantation genetic testing for aneuploidies in advanced maternal age women |
| topic | Preimplantation genetic testing for aneuploidy Next-generation sequencing Advanced maternal age Pregnancy outcomes |
| url | http://www.sciencedirect.com/science/article/pii/S1028455923001894 |
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