Oral valganciclovir in human immunodeficiency virus-positive patients suffering from cytomegalovirus retinitis at a tertiary care hospital in North India
Purpose: To study clinical efficacy of valganciclovir in cytomegalovirus retinitis (CMVR) in human immunodeficiency virus (HIV)-positive-positive patients in a tertiary care clinic in a developing nation. Methods: In a retrospective study, systemic and ocular records of HIV patients suffering from C...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2022;volume=70;issue=7;spage=2472;epage=2475;aulast=Markan |
| _version_ | 1818047433049899008 |
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| author | Ashish Markan Nikita Gupta Mohit Dogra Aman Sharma Ramandeep Singh |
| author_facet | Ashish Markan Nikita Gupta Mohit Dogra Aman Sharma Ramandeep Singh |
| author_sort | Ashish Markan |
| collection | DOAJ |
| description | Purpose: To study clinical efficacy of valganciclovir in cytomegalovirus retinitis (CMVR) in human immunodeficiency virus (HIV)-positive-positive patients in a tertiary care clinic in a developing nation. Methods: In a retrospective study, systemic and ocular records of HIV patients suffering from CMVR and treated with valganciclovir, were analyzed. Primary outcome measures were involvement of the other eye, incidence of retinal detachment, systemic involvement, and mortality encountered. Secondary outcome measures included change in BCVA. Results: Out of nine patients who were included, two patients developed CMVR in the other eye and only one patient (11.11%) developed retinal detachment during the course of the study. No patient developed any systemic manifestations or had mortality during the course of the study. The change in BCVA was not statistically significant. Conclusion: Use of oral valganciclovir showed good outcome and was found to be a better alternative compared to the use of intravitreal ganciclovir in the literature. Introduction of valganciclovir at an affordable price in developing nations can decrease disease burden. |
| first_indexed | 2024-12-10T10:05:42Z |
| format | Article |
| id | doaj.art-7d7c87e2e5d14c648f8d8521e3248b55 |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-12-10T10:05:42Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-7d7c87e2e5d14c648f8d8521e3248b552022-12-22T01:53:15ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892022-01-017072472247510.4103/ijo.IJO_2787_21Oral valganciclovir in human immunodeficiency virus-positive patients suffering from cytomegalovirus retinitis at a tertiary care hospital in North IndiaAshish MarkanNikita GuptaMohit DograAman SharmaRamandeep SinghPurpose: To study clinical efficacy of valganciclovir in cytomegalovirus retinitis (CMVR) in human immunodeficiency virus (HIV)-positive-positive patients in a tertiary care clinic in a developing nation. Methods: In a retrospective study, systemic and ocular records of HIV patients suffering from CMVR and treated with valganciclovir, were analyzed. Primary outcome measures were involvement of the other eye, incidence of retinal detachment, systemic involvement, and mortality encountered. Secondary outcome measures included change in BCVA. Results: Out of nine patients who were included, two patients developed CMVR in the other eye and only one patient (11.11%) developed retinal detachment during the course of the study. No patient developed any systemic manifestations or had mortality during the course of the study. The change in BCVA was not statistically significant. Conclusion: Use of oral valganciclovir showed good outcome and was found to be a better alternative compared to the use of intravitreal ganciclovir in the literature. Introduction of valganciclovir at an affordable price in developing nations can decrease disease burden.http://www.ijo.in/article.asp?issn=0301-4738;year=2022;volume=70;issue=7;spage=2472;epage=2475;aulast=Markanaidscmv retinitisdeveloping nationhivsystemic therapyvalganciclovir |
| spellingShingle | Ashish Markan Nikita Gupta Mohit Dogra Aman Sharma Ramandeep Singh Oral valganciclovir in human immunodeficiency virus-positive patients suffering from cytomegalovirus retinitis at a tertiary care hospital in North India Indian Journal of Ophthalmology aids cmv retinitis developing nation hiv systemic therapy valganciclovir |
| title | Oral valganciclovir in human immunodeficiency virus-positive patients suffering from cytomegalovirus retinitis at a tertiary care hospital in North India |
| title_full | Oral valganciclovir in human immunodeficiency virus-positive patients suffering from cytomegalovirus retinitis at a tertiary care hospital in North India |
| title_fullStr | Oral valganciclovir in human immunodeficiency virus-positive patients suffering from cytomegalovirus retinitis at a tertiary care hospital in North India |
| title_full_unstemmed | Oral valganciclovir in human immunodeficiency virus-positive patients suffering from cytomegalovirus retinitis at a tertiary care hospital in North India |
| title_short | Oral valganciclovir in human immunodeficiency virus-positive patients suffering from cytomegalovirus retinitis at a tertiary care hospital in North India |
| title_sort | oral valganciclovir in human immunodeficiency virus positive patients suffering from cytomegalovirus retinitis at a tertiary care hospital in north india |
| topic | aids cmv retinitis developing nation hiv systemic therapy valganciclovir |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2022;volume=70;issue=7;spage=2472;epage=2475;aulast=Markan |
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