Multiple Functions of Ten-eleven Translocation 1 during Tumorigenesis
Objective: Aberrant expression of ten-eleven translocation 1 (TET1) plays a critical role in tumor development and progression. We systematically summarized the latest research progress on the role and mechanisms of TET1 in cancer biology. Data Sources: Relevant articles published in English from 19...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer
2016-01-01
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| Series: | Chinese Medical Journal |
| Subjects: | |
| Online Access: | http://www.cmj.org/article.asp?issn=0366-6999;year=2016;volume=129;issue=14;spage=1744;epage=1751;aulast=Tian |
| _version_ | 1818287879932084224 |
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| author | Yi-Ping Tian Yi-Min Zhu Xiao-Hui Sun Mao-De Lai |
| author_facet | Yi-Ping Tian Yi-Min Zhu Xiao-Hui Sun Mao-De Lai |
| author_sort | Yi-Ping Tian |
| collection | DOAJ |
| description | Objective: Aberrant expression of ten-eleven translocation 1 (TET1) plays a critical role in tumor development and progression. We systematically summarized the latest research progress on the role and mechanisms of TET1 in cancer biology.
Data Sources: Relevant articles published in English from 1980 to April 2016 were selected from the PubMed database. The terms “ten-eleven translocation 1,” “5mC,” “5hmC,” “microRNA,” “hypoxia,” and “embryonic stem cell” were used for the search.
Study Selection: Articles focusing on the role and mechanism of TET1 in tumor were reviewed, including clinical and basic research articles.
Results: TET proteins, the key enzymes converting 5-methylcytosine to 5-hydroxymethylcytosine, play vital roles in DNA demethylation regulation. Recent studies have shown that loss of TET1 is associated with tumorigenesis and can be used as a potential biomarker for cancer therapy, which indicates that TET1 serves as tumor suppressor gene. Moreover, besides its dioxygenase activity, TET1 could induce epithelial-mesenchymal transition and act as a coactivator to regulate gene transcription, such as developmental regulator in embryonic stem cells (ESCs) and hypoxia-responsive gene in cancer. The regulation of TET1 is also correlated with microRNA in a posttranscriptional modification process. Hence, it is complex but critical to comprehend the mechanisms of TET1 in the biology of ESCs and cancer.
Conclusions: TET1 not only serves as a demethylation enzyme but also plays multiple roles during tumorigenesis and progression. More studies should be carried out to elucidate the exact mechanisms of TET1 and its associations with cancer before considering it as a therapeutic tool. |
| first_indexed | 2024-12-13T01:47:30Z |
| format | Article |
| id | doaj.art-7d7db38979224a08b917be46841c199d |
| institution | Directory Open Access Journal |
| issn | 0366-6999 |
| language | English |
| last_indexed | 2024-12-13T01:47:30Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Chinese Medical Journal |
| spelling | doaj.art-7d7db38979224a08b917be46841c199d2022-12-22T00:03:36ZengWolters KluwerChinese Medical Journal0366-69992016-01-01129141744175110.4103/0366-6999.185873Multiple Functions of Ten-eleven Translocation 1 during TumorigenesisYi-Ping TianYi-Min ZhuXiao-Hui SunMao-De LaiObjective: Aberrant expression of ten-eleven translocation 1 (TET1) plays a critical role in tumor development and progression. We systematically summarized the latest research progress on the role and mechanisms of TET1 in cancer biology. Data Sources: Relevant articles published in English from 1980 to April 2016 were selected from the PubMed database. The terms “ten-eleven translocation 1,” “5mC,” “5hmC,” “microRNA,” “hypoxia,” and “embryonic stem cell” were used for the search. Study Selection: Articles focusing on the role and mechanism of TET1 in tumor were reviewed, including clinical and basic research articles. Results: TET proteins, the key enzymes converting 5-methylcytosine to 5-hydroxymethylcytosine, play vital roles in DNA demethylation regulation. Recent studies have shown that loss of TET1 is associated with tumorigenesis and can be used as a potential biomarker for cancer therapy, which indicates that TET1 serves as tumor suppressor gene. Moreover, besides its dioxygenase activity, TET1 could induce epithelial-mesenchymal transition and act as a coactivator to regulate gene transcription, such as developmental regulator in embryonic stem cells (ESCs) and hypoxia-responsive gene in cancer. The regulation of TET1 is also correlated with microRNA in a posttranscriptional modification process. Hence, it is complex but critical to comprehend the mechanisms of TET1 in the biology of ESCs and cancer. Conclusions: TET1 not only serves as a demethylation enzyme but also plays multiple roles during tumorigenesis and progression. More studies should be carried out to elucidate the exact mechanisms of TET1 and its associations with cancer before considering it as a therapeutic tool.http://www.cmj.org/article.asp?issn=0366-6999;year=2016;volume=129;issue=14;spage=1744;epage=1751;aulast=Tian5-hydroxymethylcytosine; 5-methylcytosine; Embryonic Stem Cells; Hypoxia; MicroRNA; Ten-eleven Translocation Proteins |
| spellingShingle | Yi-Ping Tian Yi-Min Zhu Xiao-Hui Sun Mao-De Lai Multiple Functions of Ten-eleven Translocation 1 during Tumorigenesis Chinese Medical Journal 5-hydroxymethylcytosine; 5-methylcytosine; Embryonic Stem Cells; Hypoxia; MicroRNA; Ten-eleven Translocation Proteins |
| title | Multiple Functions of Ten-eleven Translocation 1 during Tumorigenesis |
| title_full | Multiple Functions of Ten-eleven Translocation 1 during Tumorigenesis |
| title_fullStr | Multiple Functions of Ten-eleven Translocation 1 during Tumorigenesis |
| title_full_unstemmed | Multiple Functions of Ten-eleven Translocation 1 during Tumorigenesis |
| title_short | Multiple Functions of Ten-eleven Translocation 1 during Tumorigenesis |
| title_sort | multiple functions of ten eleven translocation 1 during tumorigenesis |
| topic | 5-hydroxymethylcytosine; 5-methylcytosine; Embryonic Stem Cells; Hypoxia; MicroRNA; Ten-eleven Translocation Proteins |
| url | http://www.cmj.org/article.asp?issn=0366-6999;year=2016;volume=129;issue=14;spage=1744;epage=1751;aulast=Tian |
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