Systematic Review of Lung Cancer Screening: Advancements and Strategies for Implementation
Lung cancer is the leading cause of cancer-related deaths in Europe, with low survival rates primarily due to late-stage diagnosis. Early detection can significantly improve survival rates, but lung cancer screening is not currently implemented in Italy. Many countries have implemented lung cancer s...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Healthcare |
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| Online Access: | https://www.mdpi.com/2227-9032/11/14/2085 |
| _version_ | 1797589112455168000 |
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| author | Daniela Amicizia Maria Francesca Piazza Francesca Marchini Matteo Astengo Federico Grammatico Alberto Battaglini Irene Schenone Camilla Sticchi Rosa Lavieri Bruno Di Silverio Giovanni Battista Andreoli Filippo Ansaldi |
| author_facet | Daniela Amicizia Maria Francesca Piazza Francesca Marchini Matteo Astengo Federico Grammatico Alberto Battaglini Irene Schenone Camilla Sticchi Rosa Lavieri Bruno Di Silverio Giovanni Battista Andreoli Filippo Ansaldi |
| author_sort | Daniela Amicizia |
| collection | DOAJ |
| description | Lung cancer is the leading cause of cancer-related deaths in Europe, with low survival rates primarily due to late-stage diagnosis. Early detection can significantly improve survival rates, but lung cancer screening is not currently implemented in Italy. Many countries have implemented lung cancer screening programs for high-risk populations, with studies showing a reduction in mortality. This review aimed to identify key areas for establishing a lung cancer screening program in Italy. A literature search was conducted in October 2022, using the PubMed and Scopus databases. Items of interest included updated evidence, approaches used in other countries, enrollment and eligibility criteria, models, cost-effectiveness studies, and smoking cessation programs. A literature search yielded 61 scientific papers, highlighting the effectiveness of low-dose computed tomography (LDCT) screening in reducing mortality among high-risk populations. The National Lung Screening Trial (NLST) in the United States demonstrated a 20% reduction in lung cancer mortality with LDCT, and other trials confirmed its potential to reduce mortality by up to 39% and detect early-stage cancers. However, false-positive results and associated harm were concerns. Economic evaluations generally supported the cost-effectiveness of LDCT screening, especially when combined with smoking cessation interventions for individuals aged 55 to 75 with a significant smoking history. Implementing a screening program in Italy requires the careful consideration of optimal strategies, population selection, result management, and the integration of smoking cessation. Resource limitations and tailored interventions for subpopulations with low-risk perception and non-adherence rates should be addressed with multidisciplinary expertise. |
| first_indexed | 2024-03-11T01:01:43Z |
| format | Article |
| id | doaj.art-7d7e27812f2946c9ae6eb19e72b8bf32 |
| institution | Directory Open Access Journal |
| issn | 2227-9032 |
| language | English |
| last_indexed | 2024-03-11T01:01:43Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Healthcare |
| spelling | doaj.art-7d7e27812f2946c9ae6eb19e72b8bf322023-11-18T19:33:47ZengMDPI AGHealthcare2227-90322023-07-011114208510.3390/healthcare11142085Systematic Review of Lung Cancer Screening: Advancements and Strategies for ImplementationDaniela Amicizia0Maria Francesca Piazza1Francesca Marchini2Matteo Astengo3Federico Grammatico4Alberto Battaglini5Irene Schenone6Camilla Sticchi7Rosa Lavieri8Bruno Di Silverio9Giovanni Battista Andreoli10Filippo Ansaldi11Regional Health Agency of Liguria (ALiSa), 16121 Genoa, ItalyRegional Health Agency of Liguria (ALiSa), 16121 Genoa, ItalyRegional Health Agency of Liguria (ALiSa), 16121 Genoa, ItalyRegional Health Agency of Liguria (ALiSa), 16121 Genoa, ItalyRegional Health Agency of Liguria (ALiSa), 16121 Genoa, ItalyRegional Health Agency of Liguria (ALiSa), 16121 Genoa, ItalyRegional Health Agency of Liguria (ALiSa), 16121 Genoa, ItalyRegional Health Agency of Liguria (ALiSa), 16121 Genoa, ItalyRegional Health Agency of Liguria (ALiSa), 16121 Genoa, ItalyRegional Health Agency of Liguria (ALiSa), 16121 Genoa, ItalyRegional Health Agency of Liguria (ALiSa), 16121 Genoa, ItalyRegional Health Agency of Liguria (ALiSa), 16121 Genoa, ItalyLung cancer is the leading cause of cancer-related deaths in Europe, with low survival rates primarily due to late-stage diagnosis. Early detection can significantly improve survival rates, but lung cancer screening is not currently implemented in Italy. Many countries have implemented lung cancer screening programs for high-risk populations, with studies showing a reduction in mortality. This review aimed to identify key areas for establishing a lung cancer screening program in Italy. A literature search was conducted in October 2022, using the PubMed and Scopus databases. Items of interest included updated evidence, approaches used in other countries, enrollment and eligibility criteria, models, cost-effectiveness studies, and smoking cessation programs. A literature search yielded 61 scientific papers, highlighting the effectiveness of low-dose computed tomography (LDCT) screening in reducing mortality among high-risk populations. The National Lung Screening Trial (NLST) in the United States demonstrated a 20% reduction in lung cancer mortality with LDCT, and other trials confirmed its potential to reduce mortality by up to 39% and detect early-stage cancers. However, false-positive results and associated harm were concerns. Economic evaluations generally supported the cost-effectiveness of LDCT screening, especially when combined with smoking cessation interventions for individuals aged 55 to 75 with a significant smoking history. Implementing a screening program in Italy requires the careful consideration of optimal strategies, population selection, result management, and the integration of smoking cessation. Resource limitations and tailored interventions for subpopulations with low-risk perception and non-adherence rates should be addressed with multidisciplinary expertise.https://www.mdpi.com/2227-9032/11/14/2085lung cancerscreening programlow-dose computed tomography (LDCT)cost-effectivenessmortality reductionhealthcare |
| spellingShingle | Daniela Amicizia Maria Francesca Piazza Francesca Marchini Matteo Astengo Federico Grammatico Alberto Battaglini Irene Schenone Camilla Sticchi Rosa Lavieri Bruno Di Silverio Giovanni Battista Andreoli Filippo Ansaldi Systematic Review of Lung Cancer Screening: Advancements and Strategies for Implementation Healthcare lung cancer screening program low-dose computed tomography (LDCT) cost-effectiveness mortality reduction healthcare |
| title | Systematic Review of Lung Cancer Screening: Advancements and Strategies for Implementation |
| title_full | Systematic Review of Lung Cancer Screening: Advancements and Strategies for Implementation |
| title_fullStr | Systematic Review of Lung Cancer Screening: Advancements and Strategies for Implementation |
| title_full_unstemmed | Systematic Review of Lung Cancer Screening: Advancements and Strategies for Implementation |
| title_short | Systematic Review of Lung Cancer Screening: Advancements and Strategies for Implementation |
| title_sort | systematic review of lung cancer screening advancements and strategies for implementation |
| topic | lung cancer screening program low-dose computed tomography (LDCT) cost-effectiveness mortality reduction healthcare |
| url | https://www.mdpi.com/2227-9032/11/14/2085 |
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