Potentials and future perspectives of multi-target drugs in cancer treatment: the next generation anti-cancer agents
Abstract Cancer is a major public health problem worldwide with more than an estimated 19.3 million new cases in 2020. The occurrence rises dramatically with age, and the overall risk accumulation is combined with the tendency for cellular repair mechanisms to be less effective in older individuals....
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-04-01
|
| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-024-01607-9 |
| _version_ | 1827277035437817856 |
|---|---|
| author | Ali Doostmohammadi Hossein Jooya Kimia Ghorbanian Sargol Gohari Mehdi Dadashpour |
| author_facet | Ali Doostmohammadi Hossein Jooya Kimia Ghorbanian Sargol Gohari Mehdi Dadashpour |
| author_sort | Ali Doostmohammadi |
| collection | DOAJ |
| description | Abstract Cancer is a major public health problem worldwide with more than an estimated 19.3 million new cases in 2020. The occurrence rises dramatically with age, and the overall risk accumulation is combined with the tendency for cellular repair mechanisms to be less effective in older individuals. Conventional cancer treatments, such as radiotherapy, surgery, and chemotherapy, have been used for decades to combat cancer. However, the emergence of novel fields of cancer research has led to the exploration of innovative treatment approaches focused on immunotherapy, epigenetic therapy, targeted therapy, multi-omics, and also multi-target therapy. The hypothesis was based on that drugs designed to act against individual targets cannot usually battle multigenic diseases like cancer. Multi-target therapies, either in combination or sequential order, have been recommended to combat acquired and intrinsic resistance to anti-cancer treatments. Several studies focused on multi-targeting treatments due to their advantages include; overcoming clonal heterogeneity, lower risk of multi-drug resistance (MDR), decreased drug toxicity, and thereby lower side effects. In this study, we'll discuss about multi-target drugs, their benefits in improving cancer treatments, and recent advances in the field of multi-targeted drugs. Also, we will study the research that performed clinical trials using multi-target therapeutic agents for cancer treatment. |
| first_indexed | 2024-04-24T07:13:05Z |
| format | Article |
| id | doaj.art-7d7f4ab39e6d415d9c58600475c04818 |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-04-24T07:13:05Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-7d7f4ab39e6d415d9c58600475c048182024-04-21T11:25:12ZengBMCCell Communication and Signaling1478-811X2024-04-0122112210.1186/s12964-024-01607-9Potentials and future perspectives of multi-target drugs in cancer treatment: the next generation anti-cancer agentsAli Doostmohammadi0Hossein Jooya1Kimia Ghorbanian2Sargol Gohari3Mehdi Dadashpour4Nervous System Stem Cells Research Center, Semnan University of Medical SciencesBiochemistry Group, Department of Chemistry, Faculty of Science, Ferdowsi University of MashhadStudent Research Committee, Semnan University of Medical SciencesDepartment of Biology, Central Tehran Branch, Islamic Azad UniversityDepartment of Medical Biotechnology, Faculty of Medicine, Semnan University of Medical SciencesAbstract Cancer is a major public health problem worldwide with more than an estimated 19.3 million new cases in 2020. The occurrence rises dramatically with age, and the overall risk accumulation is combined with the tendency for cellular repair mechanisms to be less effective in older individuals. Conventional cancer treatments, such as radiotherapy, surgery, and chemotherapy, have been used for decades to combat cancer. However, the emergence of novel fields of cancer research has led to the exploration of innovative treatment approaches focused on immunotherapy, epigenetic therapy, targeted therapy, multi-omics, and also multi-target therapy. The hypothesis was based on that drugs designed to act against individual targets cannot usually battle multigenic diseases like cancer. Multi-target therapies, either in combination or sequential order, have been recommended to combat acquired and intrinsic resistance to anti-cancer treatments. Several studies focused on multi-targeting treatments due to their advantages include; overcoming clonal heterogeneity, lower risk of multi-drug resistance (MDR), decreased drug toxicity, and thereby lower side effects. In this study, we'll discuss about multi-target drugs, their benefits in improving cancer treatments, and recent advances in the field of multi-targeted drugs. Also, we will study the research that performed clinical trials using multi-target therapeutic agents for cancer treatment.https://doi.org/10.1186/s12964-024-01607-9Cancer treatmentDrug resistancePolypharmacologyMulti-target drugs |
| spellingShingle | Ali Doostmohammadi Hossein Jooya Kimia Ghorbanian Sargol Gohari Mehdi Dadashpour Potentials and future perspectives of multi-target drugs in cancer treatment: the next generation anti-cancer agents Cell Communication and Signaling Cancer treatment Drug resistance Polypharmacology Multi-target drugs |
| title | Potentials and future perspectives of multi-target drugs in cancer treatment: the next generation anti-cancer agents |
| title_full | Potentials and future perspectives of multi-target drugs in cancer treatment: the next generation anti-cancer agents |
| title_fullStr | Potentials and future perspectives of multi-target drugs in cancer treatment: the next generation anti-cancer agents |
| title_full_unstemmed | Potentials and future perspectives of multi-target drugs in cancer treatment: the next generation anti-cancer agents |
| title_short | Potentials and future perspectives of multi-target drugs in cancer treatment: the next generation anti-cancer agents |
| title_sort | potentials and future perspectives of multi target drugs in cancer treatment the next generation anti cancer agents |
| topic | Cancer treatment Drug resistance Polypharmacology Multi-target drugs |
| url | https://doi.org/10.1186/s12964-024-01607-9 |
| work_keys_str_mv | AT alidoostmohammadi potentialsandfutureperspectivesofmultitargetdrugsincancertreatmentthenextgenerationanticanceragents AT hosseinjooya potentialsandfutureperspectivesofmultitargetdrugsincancertreatmentthenextgenerationanticanceragents AT kimiaghorbanian potentialsandfutureperspectivesofmultitargetdrugsincancertreatmentthenextgenerationanticanceragents AT sargolgohari potentialsandfutureperspectivesofmultitargetdrugsincancertreatmentthenextgenerationanticanceragents AT mehdidadashpour potentialsandfutureperspectivesofmultitargetdrugsincancertreatmentthenextgenerationanticanceragents |