Telocytes and Macrophages in the Gut: From Morphology to Function, Do the Two Cell Types Interact with Each Other? Which Helps Which?
Telocytes and macrophages are ubiquitous cells located in loose connective tissues and share the same mesenchymal origin. Despite these common elements, depending on where they reside, these two cell types are profoundly different in terms of their morphology and functions. The purpose of this revie...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/15/8435 |
| _version_ | 1797441904522035200 |
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| author | Maria Giuliana Vannucchi |
| author_facet | Maria Giuliana Vannucchi |
| author_sort | Maria Giuliana Vannucchi |
| collection | DOAJ |
| description | Telocytes and macrophages are ubiquitous cells located in loose connective tissues and share the same mesenchymal origin. Despite these common elements, depending on where they reside, these two cell types are profoundly different in terms of their morphology and functions. The purpose of this review is to provide an update on the knowledge regarding telocytes and macrophages in the gut, where their presence and significance have long been underestimated or misunderstood. The focus will be on the possibility that these two cell types interact with each other and on the potential meaning of these interactions. Based on the complexity of the topic, the variety of possible methodological approaches and the expertise of the author, the point of view in the discussion of the literature data will be mainly morphological. Furthermore, considering the relatively recent period in which these cell types have acquired a primary role in gastrointestinal functions, the attention will be greatly confined to those articles published in the last decade. The microbiota, another main protagonist in this context, will be mentioned only in passing. It is hoped that this review, although not exhaustive, will highlight the importance of macrophages and telocytes in the complex mechanisms that ensure intestinal functions. |
| first_indexed | 2024-03-09T12:32:55Z |
| format | Article |
| id | doaj.art-7d803506f80d4592a64a7fc9d5ce9bb1 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T12:32:55Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-7d803506f80d4592a64a7fc9d5ce9bb12023-11-30T22:27:56ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-07-012315843510.3390/ijms23158435Telocytes and Macrophages in the Gut: From Morphology to Function, Do the Two Cell Types Interact with Each Other? Which Helps Which?Maria Giuliana Vannucchi0Department of Experimental and Clinical Medicine, University of Florence, 50139 Florence, ItalyTelocytes and macrophages are ubiquitous cells located in loose connective tissues and share the same mesenchymal origin. Despite these common elements, depending on where they reside, these two cell types are profoundly different in terms of their morphology and functions. The purpose of this review is to provide an update on the knowledge regarding telocytes and macrophages in the gut, where their presence and significance have long been underestimated or misunderstood. The focus will be on the possibility that these two cell types interact with each other and on the potential meaning of these interactions. Based on the complexity of the topic, the variety of possible methodological approaches and the expertise of the author, the point of view in the discussion of the literature data will be mainly morphological. Furthermore, considering the relatively recent period in which these cell types have acquired a primary role in gastrointestinal functions, the attention will be greatly confined to those articles published in the last decade. The microbiota, another main protagonist in this context, will be mentioned only in passing. It is hoped that this review, although not exhaustive, will highlight the importance of macrophages and telocytes in the complex mechanisms that ensure intestinal functions.https://www.mdpi.com/1422-0067/23/15/8435PDGFRα-positive cellsinterstitial cellsimmune cellscell contactstransmission electron microscopyimmunohistochemistry |
| spellingShingle | Maria Giuliana Vannucchi Telocytes and Macrophages in the Gut: From Morphology to Function, Do the Two Cell Types Interact with Each Other? Which Helps Which? International Journal of Molecular Sciences PDGFRα-positive cells interstitial cells immune cells cell contacts transmission electron microscopy immunohistochemistry |
| title | Telocytes and Macrophages in the Gut: From Morphology to Function, Do the Two Cell Types Interact with Each Other? Which Helps Which? |
| title_full | Telocytes and Macrophages in the Gut: From Morphology to Function, Do the Two Cell Types Interact with Each Other? Which Helps Which? |
| title_fullStr | Telocytes and Macrophages in the Gut: From Morphology to Function, Do the Two Cell Types Interact with Each Other? Which Helps Which? |
| title_full_unstemmed | Telocytes and Macrophages in the Gut: From Morphology to Function, Do the Two Cell Types Interact with Each Other? Which Helps Which? |
| title_short | Telocytes and Macrophages in the Gut: From Morphology to Function, Do the Two Cell Types Interact with Each Other? Which Helps Which? |
| title_sort | telocytes and macrophages in the gut from morphology to function do the two cell types interact with each other which helps which |
| topic | PDGFRα-positive cells interstitial cells immune cells cell contacts transmission electron microscopy immunohistochemistry |
| url | https://www.mdpi.com/1422-0067/23/15/8435 |
| work_keys_str_mv | AT mariagiulianavannucchi telocytesandmacrophagesinthegutfrommorphologytofunctiondothetwocelltypesinteractwitheachotherwhichhelpswhich |