Early preclinical work with gonadotropin-releasing hormone analogues
In this article, I provide a narrative remembrance of the many early proof-of-concept studies that were performed at the Jones Institute for Reproductive Medicine in the late 1980s and early 1990s. A group, led by the late Dr. Gary Hodgen, piloted some of the ways gonadotropin-releasing hormone anal...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | F&S Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666334123000090 |
| _version_ | 1797829078472982528 |
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| author | Keith Gordon, Ph.D. |
| author_facet | Keith Gordon, Ph.D. |
| author_sort | Keith Gordon, Ph.D. |
| collection | DOAJ |
| description | In this article, I provide a narrative remembrance of the many early proof-of-concept studies that were performed at the Jones Institute for Reproductive Medicine in the late 1980s and early 1990s. A group, led by the late Dr. Gary Hodgen, piloted some of the ways gonadotropin-releasing hormone analogues are now being used clinically. We also put many different early peptide and small molecule (orally active) gonadotropin-releasing hormone antagonists through a battery of tests to explore their effects on male and female reproductive hormones. Most of the compounds we tested never reached the clinic because of various reasons. However, some have and are now making a difference in people’s lives. |
| first_indexed | 2024-04-09T13:14:41Z |
| format | Article |
| id | doaj.art-7d811206ec434d66ab9206aca54fde4c |
| institution | Directory Open Access Journal |
| issn | 2666-3341 |
| language | English |
| last_indexed | 2024-04-09T13:14:41Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | F&S Reports |
| spelling | doaj.art-7d811206ec434d66ab9206aca54fde4c2023-05-12T04:17:14ZengElsevierF&S Reports2666-33412023-06-01425155Early preclinical work with gonadotropin-releasing hormone analoguesKeith Gordon, Ph.D.0Reprint requests: Keith Gordon, Ph.D., Organon Inc, 1180 Church Road, Lansdale, Pennsylvania 19446.; Global Medical Affairs, Organon Inc, Lansdale, PennsylvaniaIn this article, I provide a narrative remembrance of the many early proof-of-concept studies that were performed at the Jones Institute for Reproductive Medicine in the late 1980s and early 1990s. A group, led by the late Dr. Gary Hodgen, piloted some of the ways gonadotropin-releasing hormone analogues are now being used clinically. We also put many different early peptide and small molecule (orally active) gonadotropin-releasing hormone antagonists through a battery of tests to explore their effects on male and female reproductive hormones. Most of the compounds we tested never reached the clinic because of various reasons. However, some have and are now making a difference in people’s lives.http://www.sciencedirect.com/science/article/pii/S2666334123000090Nonhuman primate modelsproof-of-conceptGnRH analoguespreclinical |
| spellingShingle | Keith Gordon, Ph.D. Early preclinical work with gonadotropin-releasing hormone analogues F&S Reports Nonhuman primate models proof-of-concept GnRH analogues preclinical |
| title | Early preclinical work with gonadotropin-releasing hormone analogues |
| title_full | Early preclinical work with gonadotropin-releasing hormone analogues |
| title_fullStr | Early preclinical work with gonadotropin-releasing hormone analogues |
| title_full_unstemmed | Early preclinical work with gonadotropin-releasing hormone analogues |
| title_short | Early preclinical work with gonadotropin-releasing hormone analogues |
| title_sort | early preclinical work with gonadotropin releasing hormone analogues |
| topic | Nonhuman primate models proof-of-concept GnRH analogues preclinical |
| url | http://www.sciencedirect.com/science/article/pii/S2666334123000090 |
| work_keys_str_mv | AT keithgordonphd earlypreclinicalworkwithgonadotropinreleasinghormoneanalogues |