Interactions between drugs and drug-nutrient in enteral nutrition: a review based on evidences
Introduction: Enteral nutrition (EN) provides calories, macronutrients and micronutrients in adequate quantity and quality to meet the patient's needs. Some drugs when crushed and diluted may have their properties altered, including the reduction of bioavailability causing the reduction of the...
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| Format: | Article |
| Language: | English |
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Arán Ediciones, S. L.
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| Series: | Nutrición Hospitalaria |
| Subjects: | |
| Online Access: | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112014001000006&lng=en&tlng=en |
| _version_ | 1828492150118023168 |
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| author | Renata Ferreira Silva Maria Rita Carvalho Garbi Novaes |
| author_facet | Renata Ferreira Silva Maria Rita Carvalho Garbi Novaes |
| author_sort | Renata Ferreira Silva |
| collection | DOAJ |
| description | Introduction: Enteral nutrition (EN) provides calories, macronutrients and micronutrients in adequate quantity and quality to meet the patient's needs. Some drugs when crushed and diluted may have their properties altered, including the reduction of bioavailability causing the reduction of the serum concentration of the drug; tube obstruction; drug-drug interaction or drug-nutrient interaction. Methods: The study was conducted through review of submitted articles in the databases of the Virtual Health Library (VHL): MEDLINE (National Library of Medicine, USA), Lilacs (Latin American and Caribbean Literature on Health Sciences) PUBMED - NCBI (National Center for Biotechnology Information) and COCHRANE. Results: For this survey, 42 articles were identified during database searching. After applying the inclusion and exclusion criteria, 08 articles were selected, obtained from the MEDLINE and Lilacs. Discussion: Some interactions were found such as the aluminium hydroxide and lactulose with the enteral nutrition, which may result in a precipitation and reduction of drug bioavailability. Mineral oil will alter the absorption of fat-soluble vitamins and reduces the tube light. Others results were found as phenytoin, warfarin, captopril and furosemide with enteral nutrition may reduce the maximum serum concentration. Conclusion: Drug interactions are more common in day-to-day activities than health professionals may suppose. Knowledge on the matter may also assist in reducing cases of obstruction of tubes, through which enteral nutrition and medications are administered. Thus, the multidisciplinary team, acting together, may have more beneficial effects to the patient. |
| first_indexed | 2024-12-11T11:15:28Z |
| format | Article |
| id | doaj.art-7d81a605359344c6833db512b4674859 |
| institution | Directory Open Access Journal |
| issn | 0212-1611 |
| language | English |
| last_indexed | 2024-12-11T11:15:28Z |
| publisher | Arán Ediciones, S. L. |
| record_format | Article |
| series | Nutrición Hospitalaria |
| spelling | doaj.art-7d81a605359344c6833db512b46748592022-12-22T01:09:22ZengArán Ediciones, S. L.Nutrición Hospitalaria0212-161130351451810.3305/nh.2014.30.3.7488S0212-16112014001000006Interactions between drugs and drug-nutrient in enteral nutrition: a review based on evidencesRenata Ferreira Silva0Maria Rita Carvalho Garbi Novaes1Foundation for Research and Education in Health SciencesFundação de Ensino e Pesquisa em Ciências da Saúde (Fepecs)Introduction: Enteral nutrition (EN) provides calories, macronutrients and micronutrients in adequate quantity and quality to meet the patient's needs. Some drugs when crushed and diluted may have their properties altered, including the reduction of bioavailability causing the reduction of the serum concentration of the drug; tube obstruction; drug-drug interaction or drug-nutrient interaction. Methods: The study was conducted through review of submitted articles in the databases of the Virtual Health Library (VHL): MEDLINE (National Library of Medicine, USA), Lilacs (Latin American and Caribbean Literature on Health Sciences) PUBMED - NCBI (National Center for Biotechnology Information) and COCHRANE. Results: For this survey, 42 articles were identified during database searching. After applying the inclusion and exclusion criteria, 08 articles were selected, obtained from the MEDLINE and Lilacs. Discussion: Some interactions were found such as the aluminium hydroxide and lactulose with the enteral nutrition, which may result in a precipitation and reduction of drug bioavailability. Mineral oil will alter the absorption of fat-soluble vitamins and reduces the tube light. Others results were found as phenytoin, warfarin, captopril and furosemide with enteral nutrition may reduce the maximum serum concentration. Conclusion: Drug interactions are more common in day-to-day activities than health professionals may suppose. Knowledge on the matter may also assist in reducing cases of obstruction of tubes, through which enteral nutrition and medications are administered. Thus, the multidisciplinary team, acting together, may have more beneficial effects to the patient.http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112014001000006&lng=en&tlng=enNutrición enteralInteracciones farmacológicasInteracciones de los alimentosInteracciones entre fármacos y alimentos |
| spellingShingle | Renata Ferreira Silva Maria Rita Carvalho Garbi Novaes Interactions between drugs and drug-nutrient in enteral nutrition: a review based on evidences Nutrición Hospitalaria Nutrición enteral Interacciones farmacológicas Interacciones de los alimentos Interacciones entre fármacos y alimentos |
| title | Interactions between drugs and drug-nutrient in enteral nutrition: a review based on evidences |
| title_full | Interactions between drugs and drug-nutrient in enteral nutrition: a review based on evidences |
| title_fullStr | Interactions between drugs and drug-nutrient in enteral nutrition: a review based on evidences |
| title_full_unstemmed | Interactions between drugs and drug-nutrient in enteral nutrition: a review based on evidences |
| title_short | Interactions between drugs and drug-nutrient in enteral nutrition: a review based on evidences |
| title_sort | interactions between drugs and drug nutrient in enteral nutrition a review based on evidences |
| topic | Nutrición enteral Interacciones farmacológicas Interacciones de los alimentos Interacciones entre fármacos y alimentos |
| url | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112014001000006&lng=en&tlng=en |
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