Oncofertility in patients with stage I epithelial ovarian cancer: fertility-sparing surgery in young women of reproductive age
Abstract Background Fertility-sparing surgery is indicated for patients with stage I epithelial ovarian cancers. We sought to evaluate the clinical outcomes and oncofertility in a cohort of patients of reproductive age with stage I epithelial ovarian cancer (EOC). Methods Overall, 108 patients of re...
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| Format: | Article |
| Language: | English |
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BMC
2017-08-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12957-017-1222-4 |
| _version_ | 1818849967767289856 |
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| author | Xuan Jiang Jiaxin Yang Mei Yu Weimin Xie Dongyan Cao Ming Wu Lingya Pan Huifang Huang Yan You Keng Shen |
| author_facet | Xuan Jiang Jiaxin Yang Mei Yu Weimin Xie Dongyan Cao Ming Wu Lingya Pan Huifang Huang Yan You Keng Shen |
| author_sort | Xuan Jiang |
| collection | DOAJ |
| description | Abstract Background Fertility-sparing surgery is indicated for patients with stage I epithelial ovarian cancers. We sought to evaluate the clinical outcomes and oncofertility in a cohort of patients of reproductive age with stage I epithelial ovarian cancer (EOC). Methods Overall, 108 patients of reproductive age (≤ 40 years) diagnosed with stage I EOC who were treated at Peking Union Medical College Hospital between 1999 and 2013 were included in the study. The Kaplan-Meier model and Cox regression analyses were used for the survival analysis. Results The type of surgery included fertility-sparing surgery (FSS) (48.1%) and radical surgery (RS) (51.9%). After a median follow-up of 83 months, we observed that grade 3 or clear-cell carcinoma was the only independent risk factor for disease-free survival and tumor-specific survival in the multivariate analysis. Patients with grade 3 or clear-cell carcinoma tended to be older than 30 years, have endometriosis, and undergo RS (p < 0.05). Fertility-sparing surgery did not affect disease-free survival or tumor-specific survival among patients of reproductive age with stage I EOC and among high-risk patients with stage IC2-3, grade 3, or clear-cell carcinoma. Thirty-four out of 52 (65.4%) FSS patients attempted to get pregnant. Twenty-eight (82.4%) achieved a successful pregnancy with a full-term delivery. Conclusions Grade 3 or clear-cell carcinoma was the only independent risk factor for survival of patients of reproductive age with stage I EOC. FSS can be safely performed on patients of reproductive age with grade 1-2, stage I EOC. The safety of FSS for grade 3 and clear-cell carcinoma warrants further investigation. |
| first_indexed | 2024-12-19T06:41:39Z |
| format | Article |
| id | doaj.art-7d84051e3dc2465b8e0ccf34e2410cd2 |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-12-19T06:41:39Z |
| publishDate | 2017-08-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-7d84051e3dc2465b8e0ccf34e2410cd22022-12-21T20:32:02ZengBMCWorld Journal of Surgical Oncology1477-78192017-08-0115111110.1186/s12957-017-1222-4Oncofertility in patients with stage I epithelial ovarian cancer: fertility-sparing surgery in young women of reproductive ageXuan Jiang0Jiaxin Yang1Mei Yu2Weimin Xie3Dongyan Cao4Ming Wu5Lingya Pan6Huifang Huang7Yan You8Keng Shen9Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical CollegeDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical CollegeDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical CollegeDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical CollegeDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical CollegeDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical CollegeDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical CollegeDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical CollegeDepartment of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical CollegeDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical CollegeAbstract Background Fertility-sparing surgery is indicated for patients with stage I epithelial ovarian cancers. We sought to evaluate the clinical outcomes and oncofertility in a cohort of patients of reproductive age with stage I epithelial ovarian cancer (EOC). Methods Overall, 108 patients of reproductive age (≤ 40 years) diagnosed with stage I EOC who were treated at Peking Union Medical College Hospital between 1999 and 2013 were included in the study. The Kaplan-Meier model and Cox regression analyses were used for the survival analysis. Results The type of surgery included fertility-sparing surgery (FSS) (48.1%) and radical surgery (RS) (51.9%). After a median follow-up of 83 months, we observed that grade 3 or clear-cell carcinoma was the only independent risk factor for disease-free survival and tumor-specific survival in the multivariate analysis. Patients with grade 3 or clear-cell carcinoma tended to be older than 30 years, have endometriosis, and undergo RS (p < 0.05). Fertility-sparing surgery did not affect disease-free survival or tumor-specific survival among patients of reproductive age with stage I EOC and among high-risk patients with stage IC2-3, grade 3, or clear-cell carcinoma. Thirty-four out of 52 (65.4%) FSS patients attempted to get pregnant. Twenty-eight (82.4%) achieved a successful pregnancy with a full-term delivery. Conclusions Grade 3 or clear-cell carcinoma was the only independent risk factor for survival of patients of reproductive age with stage I EOC. FSS can be safely performed on patients of reproductive age with grade 1-2, stage I EOC. The safety of FSS for grade 3 and clear-cell carcinoma warrants further investigation.http://link.springer.com/article/10.1186/s12957-017-1222-4Fertility-sparing surgeryEpithelial ovarian cancerStage IReproductive ageSurvival |
| spellingShingle | Xuan Jiang Jiaxin Yang Mei Yu Weimin Xie Dongyan Cao Ming Wu Lingya Pan Huifang Huang Yan You Keng Shen Oncofertility in patients with stage I epithelial ovarian cancer: fertility-sparing surgery in young women of reproductive age World Journal of Surgical Oncology Fertility-sparing surgery Epithelial ovarian cancer Stage I Reproductive age Survival |
| title | Oncofertility in patients with stage I epithelial ovarian cancer: fertility-sparing surgery in young women of reproductive age |
| title_full | Oncofertility in patients with stage I epithelial ovarian cancer: fertility-sparing surgery in young women of reproductive age |
| title_fullStr | Oncofertility in patients with stage I epithelial ovarian cancer: fertility-sparing surgery in young women of reproductive age |
| title_full_unstemmed | Oncofertility in patients with stage I epithelial ovarian cancer: fertility-sparing surgery in young women of reproductive age |
| title_short | Oncofertility in patients with stage I epithelial ovarian cancer: fertility-sparing surgery in young women of reproductive age |
| title_sort | oncofertility in patients with stage i epithelial ovarian cancer fertility sparing surgery in young women of reproductive age |
| topic | Fertility-sparing surgery Epithelial ovarian cancer Stage I Reproductive age Survival |
| url | http://link.springer.com/article/10.1186/s12957-017-1222-4 |
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