The Role of Autophagy in Pancreatic Cancer—Recent Advances
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers with a 5-year survival rate of only 9%, despite ongoing efforts to improve treatment. This dismal prognosis is due to the difficulty of early stage diagnosis, drug resistance, and likelihood of metastasis development. It is...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-12-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/9/1/7 |
| _version_ | 1797709481687121920 |
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| author | Maria New Sharon Tooze |
| author_facet | Maria New Sharon Tooze |
| author_sort | Maria New |
| collection | DOAJ |
| description | Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers with a 5-year survival rate of only 9%, despite ongoing efforts to improve treatment. This dismal prognosis is due to the difficulty of early stage diagnosis, drug resistance, and likelihood of metastasis development. It is therefore of great importance to identify appropriate therapeutic targets and gain a greater understanding of PDAC biology. Autophagy is a membrane-mediated degradation and recycling mechanism, which is crucial for cell homeostasis. There is evidence for both a tumor-suppressive and a tumor-promoting role of autophagy in cancer, and this is likely context dependent. Within PDAC, a large body of evidence points towards autophagy being required for tumor survival and metabolism. In this review, we describe the recent advances in the understanding of the role and regulation of autophagy in PDAC. |
| first_indexed | 2024-03-12T06:37:09Z |
| format | Article |
| id | doaj.art-7d8550a26b954749a886b6ea1fa8bb2f |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-12T06:37:09Z |
| publishDate | 2019-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-7d8550a26b954749a886b6ea1fa8bb2f2023-09-03T01:14:11ZengMDPI AGBiology2079-77372019-12-0191710.3390/biology9010007biology9010007The Role of Autophagy in Pancreatic Cancer—Recent AdvancesMaria New0Sharon Tooze1Molecular Cell Biology of Autophagy Laboratory, The Francis Crick Institute, London NW1 1AT, UKMolecular Cell Biology of Autophagy Laboratory, The Francis Crick Institute, London NW1 1AT, UKPancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers with a 5-year survival rate of only 9%, despite ongoing efforts to improve treatment. This dismal prognosis is due to the difficulty of early stage diagnosis, drug resistance, and likelihood of metastasis development. It is therefore of great importance to identify appropriate therapeutic targets and gain a greater understanding of PDAC biology. Autophagy is a membrane-mediated degradation and recycling mechanism, which is crucial for cell homeostasis. There is evidence for both a tumor-suppressive and a tumor-promoting role of autophagy in cancer, and this is likely context dependent. Within PDAC, a large body of evidence points towards autophagy being required for tumor survival and metabolism. In this review, we describe the recent advances in the understanding of the role and regulation of autophagy in PDAC.https://www.mdpi.com/2079-7737/9/1/7autophagycancerpdachypoxia |
| spellingShingle | Maria New Sharon Tooze The Role of Autophagy in Pancreatic Cancer—Recent Advances Biology autophagy cancer pdac hypoxia |
| title | The Role of Autophagy in Pancreatic Cancer—Recent Advances |
| title_full | The Role of Autophagy in Pancreatic Cancer—Recent Advances |
| title_fullStr | The Role of Autophagy in Pancreatic Cancer—Recent Advances |
| title_full_unstemmed | The Role of Autophagy in Pancreatic Cancer—Recent Advances |
| title_short | The Role of Autophagy in Pancreatic Cancer—Recent Advances |
| title_sort | role of autophagy in pancreatic cancer recent advances |
| topic | autophagy cancer pdac hypoxia |
| url | https://www.mdpi.com/2079-7737/9/1/7 |
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