Targeting p97 to disrupt protein homeostasis in cancer.
Cancer cells are addicted to numerous non-oncogenic traits that enable them to thrive. Proteotoxic stress is one such non-oncogenic trait that is experienced by all tumor cells, owing to increased genomic abnormalities and the resulting synthesis and accumulation of non-stoichiometric amounts of cel...
Main Authors: | Pratikkumar Harsukhbhai Vekaria, Trisha Home, Scott Weir, Frank J Schoenen, Rekha Rao |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2016-08-01
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Series: | Frontiers in Oncology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2016.00181/full |
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