Cost-effectiveness of inactivated seasonal influenza vaccination in a cohort of Thai children ≤60 months of age.
Vaccination is the best measure to prevent influenza. We conducted a cost-effectiveness evaluation of trivalent inactivated seasonal influenza vaccination, compared to no vaccination, in children ≤60 months of age participating in a prospective cohort study in Bangkok, Thailand.A static decision tre...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5570265?pdf=render |
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| author | Wanitchaya Kittikraisak Piyarat Suntarattiwong Darunee Ditsungnoen Sarah E Pallas Taiwo O Abimbola Chonticha Klungthong Stefan Fernandez Suchada Srisarang Tawee Chotpitayasunondh Fatimah S Dawood Sonja J Olsen Kim A Lindblade |
| author_facet | Wanitchaya Kittikraisak Piyarat Suntarattiwong Darunee Ditsungnoen Sarah E Pallas Taiwo O Abimbola Chonticha Klungthong Stefan Fernandez Suchada Srisarang Tawee Chotpitayasunondh Fatimah S Dawood Sonja J Olsen Kim A Lindblade |
| author_sort | Wanitchaya Kittikraisak |
| collection | DOAJ |
| description | Vaccination is the best measure to prevent influenza. We conducted a cost-effectiveness evaluation of trivalent inactivated seasonal influenza vaccination, compared to no vaccination, in children ≤60 months of age participating in a prospective cohort study in Bangkok, Thailand.A static decision tree model was constructed to simulate the population of children in the cohort. Proportions of children with laboratory-confirmed influenza were derived from children followed weekly. The societal perspective and one-year analytic horizon were used for each influenza season; the model was repeated for three influenza seasons (2012-2014). Direct and indirect costs associated with influenza illness were collected and summed. Cost of the trivalent inactivated seasonal influenza vaccine (IIV3) including promotion, administration, and supervision cost was added for children who were vaccinated. Quality-adjusted life years (QALY), derived from literature, were used to quantify health outcomes. The incremental cost-effectiveness ratio (ICER) was calculated as the difference in the expected total costs between the vaccinated and unvaccinated groups divided by the difference in QALYs for both groups.Compared to no vaccination, IIV3 vaccination among children ≤60 months in our cohort was not cost-effective in the introductory year (2012 season; 24,450 USD/QALY gained), highly cost-effective in the 2013 season (554 USD/QALY gained), and cost-effective in the 2014 season (16,200 USD/QALY gained).The cost-effectiveness of IIV3 vaccination among children participating in the cohort study varied by influenza season, with vaccine cost and proportion of high-risk children demonstrating the greatest influence in sensitivity analyses. Vaccinating children against influenza can be economically favorable depending on the maturity of the program, influenza vaccine performance, and target population. |
| first_indexed | 2024-12-17T07:38:59Z |
| format | Article |
| id | doaj.art-7d87bd2570db4b0d82f1905a5303857f |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T07:38:59Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj.art-7d87bd2570db4b0d82f1905a5303857f2022-12-21T21:58:14ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01128e018339110.1371/journal.pone.0183391Cost-effectiveness of inactivated seasonal influenza vaccination in a cohort of Thai children ≤60 months of age.Wanitchaya KittikraisakPiyarat SuntarattiwongDarunee DitsungnoenSarah E PallasTaiwo O AbimbolaChonticha KlungthongStefan FernandezSuchada SrisarangTawee ChotpitayasunondhFatimah S DawoodSonja J OlsenKim A LindbladeVaccination is the best measure to prevent influenza. We conducted a cost-effectiveness evaluation of trivalent inactivated seasonal influenza vaccination, compared to no vaccination, in children ≤60 months of age participating in a prospective cohort study in Bangkok, Thailand.A static decision tree model was constructed to simulate the population of children in the cohort. Proportions of children with laboratory-confirmed influenza were derived from children followed weekly. The societal perspective and one-year analytic horizon were used for each influenza season; the model was repeated for three influenza seasons (2012-2014). Direct and indirect costs associated with influenza illness were collected and summed. Cost of the trivalent inactivated seasonal influenza vaccine (IIV3) including promotion, administration, and supervision cost was added for children who were vaccinated. Quality-adjusted life years (QALY), derived from literature, were used to quantify health outcomes. The incremental cost-effectiveness ratio (ICER) was calculated as the difference in the expected total costs between the vaccinated and unvaccinated groups divided by the difference in QALYs for both groups.Compared to no vaccination, IIV3 vaccination among children ≤60 months in our cohort was not cost-effective in the introductory year (2012 season; 24,450 USD/QALY gained), highly cost-effective in the 2013 season (554 USD/QALY gained), and cost-effective in the 2014 season (16,200 USD/QALY gained).The cost-effectiveness of IIV3 vaccination among children participating in the cohort study varied by influenza season, with vaccine cost and proportion of high-risk children demonstrating the greatest influence in sensitivity analyses. Vaccinating children against influenza can be economically favorable depending on the maturity of the program, influenza vaccine performance, and target population.http://europepmc.org/articles/PMC5570265?pdf=render |
| spellingShingle | Wanitchaya Kittikraisak Piyarat Suntarattiwong Darunee Ditsungnoen Sarah E Pallas Taiwo O Abimbola Chonticha Klungthong Stefan Fernandez Suchada Srisarang Tawee Chotpitayasunondh Fatimah S Dawood Sonja J Olsen Kim A Lindblade Cost-effectiveness of inactivated seasonal influenza vaccination in a cohort of Thai children ≤60 months of age. PLoS ONE |
| title | Cost-effectiveness of inactivated seasonal influenza vaccination in a cohort of Thai children ≤60 months of age. |
| title_full | Cost-effectiveness of inactivated seasonal influenza vaccination in a cohort of Thai children ≤60 months of age. |
| title_fullStr | Cost-effectiveness of inactivated seasonal influenza vaccination in a cohort of Thai children ≤60 months of age. |
| title_full_unstemmed | Cost-effectiveness of inactivated seasonal influenza vaccination in a cohort of Thai children ≤60 months of age. |
| title_short | Cost-effectiveness of inactivated seasonal influenza vaccination in a cohort of Thai children ≤60 months of age. |
| title_sort | cost effectiveness of inactivated seasonal influenza vaccination in a cohort of thai children ≤60 months of age |
| url | http://europepmc.org/articles/PMC5570265?pdf=render |
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