The Benefits of Astaxanthin to Improve Pain Relief in Patients with Painful Diabetic Neuropathy: An Open-Label, Randomized Controlled Trial
Treatment of diabetic neuropathy is still carried out by providing symptomatic therapy, which only improves ± 50% of the total symptoms felt by patients, but does not tackle the underlying causes of the disease. Astaxanthin is a potent antioxidant, anti-inflammatory, and anti-diabetic carotenoid tha...
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| Format: | Article |
| Language: | English |
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Universitas Indonesia
2021-12-01
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| Series: | Pharmaceutical Sciences and Research |
| Subjects: | |
| Online Access: | https://scholarhub.ui.ac.id/psr/vol8/iss3/3/ |
| _version_ | 1818772924295806976 |
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| author | Rizaldy Taslim Pinzon Mary Rose Angelina Budi Harsana |
| author_facet | Rizaldy Taslim Pinzon Mary Rose Angelina Budi Harsana |
| author_sort | Rizaldy Taslim Pinzon |
| collection | DOAJ |
| description | Treatment of diabetic neuropathy is still carried out by providing symptomatic therapy, which only improves ± 50% of the total symptoms felt by patients, but does not tackle the underlying causes of the disease. Astaxanthin is a potent antioxidant, anti-inflammatory, and anti-diabetic carotenoid that could be an additional treatment option. We aimed to measure the effectiveness of administering astaxanthin as an additional therapy to improve the impact of pain and discomfort experienced daily by diabetes mellitus patients with painful diabetic neuropathy. We conducted a randomized experimental study with an open label design of 36 patients who had been diagnosed with painful diabetic neuropathy. The control group was treated with standard treatment for painful diabetic neuropathy, and the experimental group was given both standard and additional therapy of astaxanthin at a dose of 6 mg once per day. The impact of pain was assessed using the Brief Pain Inventory (BPI) before administering astaxanthin and on the 4th and 8th weeks after administering astaxanthin. The administration of therapy showed a significant improvement in the impact of pain experienced daily by patients on both treatment groups (p<0.05). However, the mean BPI score of the control and the experimental groups did not differ significantly each week (p>0.05). There is a significant improvement in the BPI of patients with painful diabetic neuropathy who were given additional treatment (add on) of astaxanthin compared to patients who were only given standard treatment for painful diabetic neuropathy. |
| first_indexed | 2024-12-18T10:17:05Z |
| format | Article |
| id | doaj.art-7d88957e9a9a4a0e861326d8f8fd5758 |
| institution | Directory Open Access Journal |
| issn | 2407-2354 2477-0612 |
| language | English |
| last_indexed | 2024-12-18T10:17:05Z |
| publishDate | 2021-12-01 |
| publisher | Universitas Indonesia |
| record_format | Article |
| series | Pharmaceutical Sciences and Research |
| spelling | doaj.art-7d88957e9a9a4a0e861326d8f8fd57582022-12-21T21:11:16ZengUniversitas IndonesiaPharmaceutical Sciences and Research2407-23542477-06122021-12-0183136144https://doi.org/10.7454/psr.v8i3.1217The Benefits of Astaxanthin to Improve Pain Relief in Patients with Painful Diabetic Neuropathy: An Open-Label, Randomized Controlled TrialRizaldy Taslim Pinzon0Mary Rose Angelina Budi Harsana1Faculty of Medicine, Duta Wacana Christian University, Yogyakarta, IndonesiaFaculty of Medicine, Duta Wacana Christian University, Yogyakarta, IndonesiaTreatment of diabetic neuropathy is still carried out by providing symptomatic therapy, which only improves ± 50% of the total symptoms felt by patients, but does not tackle the underlying causes of the disease. Astaxanthin is a potent antioxidant, anti-inflammatory, and anti-diabetic carotenoid that could be an additional treatment option. We aimed to measure the effectiveness of administering astaxanthin as an additional therapy to improve the impact of pain and discomfort experienced daily by diabetes mellitus patients with painful diabetic neuropathy. We conducted a randomized experimental study with an open label design of 36 patients who had been diagnosed with painful diabetic neuropathy. The control group was treated with standard treatment for painful diabetic neuropathy, and the experimental group was given both standard and additional therapy of astaxanthin at a dose of 6 mg once per day. The impact of pain was assessed using the Brief Pain Inventory (BPI) before administering astaxanthin and on the 4th and 8th weeks after administering astaxanthin. The administration of therapy showed a significant improvement in the impact of pain experienced daily by patients on both treatment groups (p<0.05). However, the mean BPI score of the control and the experimental groups did not differ significantly each week (p>0.05). There is a significant improvement in the BPI of patients with painful diabetic neuropathy who were given additional treatment (add on) of astaxanthin compared to patients who were only given standard treatment for painful diabetic neuropathy.https://scholarhub.ui.ac.id/psr/vol8/iss3/3/astaxanthinantioxidantpainful diabetic neuropathythe impact of pain |
| spellingShingle | Rizaldy Taslim Pinzon Mary Rose Angelina Budi Harsana The Benefits of Astaxanthin to Improve Pain Relief in Patients with Painful Diabetic Neuropathy: An Open-Label, Randomized Controlled Trial Pharmaceutical Sciences and Research astaxanthin antioxidant painful diabetic neuropathy the impact of pain |
| title | The Benefits of Astaxanthin to Improve Pain Relief in Patients with Painful Diabetic Neuropathy: An Open-Label, Randomized Controlled Trial |
| title_full | The Benefits of Astaxanthin to Improve Pain Relief in Patients with Painful Diabetic Neuropathy: An Open-Label, Randomized Controlled Trial |
| title_fullStr | The Benefits of Astaxanthin to Improve Pain Relief in Patients with Painful Diabetic Neuropathy: An Open-Label, Randomized Controlled Trial |
| title_full_unstemmed | The Benefits of Astaxanthin to Improve Pain Relief in Patients with Painful Diabetic Neuropathy: An Open-Label, Randomized Controlled Trial |
| title_short | The Benefits of Astaxanthin to Improve Pain Relief in Patients with Painful Diabetic Neuropathy: An Open-Label, Randomized Controlled Trial |
| title_sort | benefits of astaxanthin to improve pain relief in patients with painful diabetic neuropathy an open label randomized controlled trial |
| topic | astaxanthin antioxidant painful diabetic neuropathy the impact of pain |
| url | https://scholarhub.ui.ac.id/psr/vol8/iss3/3/ |
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