Initial observations on sexual dysfunction as a symptom of chemotherapy-induced peripheral neuropathy
Introduction: Peripheral neuropathy (PNP) in feet and/or hands and sexual dysfunction are common side effects of cancer therapies. In patients with other diseases, there is evidence of an association between peripheral nervous system disorders and sexual dysfunction due to the impact of impaired neu...
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| Format: | Article |
| Language: | deu |
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German Medical Science GMS Publishing House
2023-06-01
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| Series: | GMS German Medical Science |
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| Online Access: | http://www.egms.de/static/en/journals/gms/2023-21/000322.shtml |
| _version_ | 1797770546257068032 |
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| author | Reimer, Nadine Brodesser, Dirk Ratiu, Dominik Zubac, Damir Lehmann, Helmar C. Baumann, Freerk T. |
| author_facet | Reimer, Nadine Brodesser, Dirk Ratiu, Dominik Zubac, Damir Lehmann, Helmar C. Baumann, Freerk T. |
| author_sort | Reimer, Nadine |
| collection | DOAJ |
| description | Introduction: Peripheral neuropathy (PNP) in feet and/or hands and sexual dysfunction are common side effects of cancer therapies. In patients with other diseases, there is evidence of an association between peripheral nervous system disorders and sexual dysfunction due to the impact of impaired neuronal control on genital organ sensitivity. In cancer patient interviews, it has now been observed that PNP and sexual dysfunction may be related. The aim of the study was to ivestigate the potential association between PNP, sexual dysfunction, and physical activity behavior.Methods: Ninety-three patients with PNP of the feet and/or hands were interviewed in August/September 2020 in a cross-sectional study regarding medical history, sexual dysfunction and functionality of the genital organs.Results: Thirty-one persons who participated in the survey provided seventeen evaluable questionnaires (four men, thirteen women). Nine women (69%) and three men (75%) reported sensory disorders of the genital organs. Three men (75%) had erectile dysfunction. All men who had sensory symptoms of the genital organs received chemotherapy, and one man also received immunotherapy. Eight women were sexually active. Five (63%) of them reported genital organ symptoms and mainly lubrication disorders. Four (80%) of the five sexually inactive women reported genital organ symptoms. Eight of the nine women with sensory symptoms of the genital organs received chemotherapy, and one woman received immunotherapy. Discussion: Our limited data suggest genital organ sensory symptoms in chemotherapy and immunotherapy patients. Genital organ symptoms do not appear to be directly related to sexual dysfunction, and the association between PNP and genital organ symptoms appears to be more pronounced in sexually inactive women. Chemotherapy could cause sensory symptoms of the genital organs and sexual dysfunction by damaging genital organ nerve fibers. Chemotherapy and anti-hormone therapy (AHT) could trigger a disturbance of the hormone balance, which in turn could be causative for sexual dysfunction. It remains open whether the cause of these disorders is the symptomatology of the genital organs or the altered hormone balance. The significance of the results is limited due to the small number of cases. To our knowledge, this study is the first of its kind in cancer patients and allows a better understanding of the association between PNP, sensory symptoms of the genital organs, and sexual dysfunction. Conclusion: In order to be able to narrow down the cause of these initial observations in cancer patients more precisely, larger studies are needed that can relate the influence of cancer therapy-induced PNP, physical activity level and hormone balance to sensory symptoms of the genital organs and sexual dysfunction. The methodology of further studies should take into account the frequent problem of low response rates in surveys on sexuality. |
| first_indexed | 2024-03-12T21:24:45Z |
| format | Article |
| id | doaj.art-7d8ca3538c4840609e5b71970d26861d |
| institution | Directory Open Access Journal |
| issn | 1612-3174 |
| language | deu |
| last_indexed | 2024-03-12T21:24:45Z |
| publishDate | 2023-06-01 |
| publisher | German Medical Science GMS Publishing House |
| record_format | Article |
| series | GMS German Medical Science |
| spelling | doaj.art-7d8ca3538c4840609e5b71970d26861d2023-07-28T09:50:53ZdeuGerman Medical Science GMS Publishing HouseGMS German Medical Science1612-31742023-06-0121Doc0810.3205/000322Initial observations on sexual dysfunction as a symptom of chemotherapy-induced peripheral neuropathyReimer, Nadine0Brodesser, Dirk1Ratiu, Dominik2Zubac, Damir3Lehmann, Helmar C.4Baumann, Freerk T.5University of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf, University Hospital of Cologne, GermanyUniversity of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf, University Hospital of Cologne, GermanyUniversity of Cologne, Clinic and Polyclinic for Gynecology and Obstetrics, University Hospital Cologne, GermanyUniversity of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf, University Hospital of Cologne, GermanyUniversity of Cologne, Clinic and Polyclinic for Neurology, University Hospital Cologne, GermanyUniversity of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf, University Hospital of Cologne, GermanyIntroduction: Peripheral neuropathy (PNP) in feet and/or hands and sexual dysfunction are common side effects of cancer therapies. In patients with other diseases, there is evidence of an association between peripheral nervous system disorders and sexual dysfunction due to the impact of impaired neuronal control on genital organ sensitivity. In cancer patient interviews, it has now been observed that PNP and sexual dysfunction may be related. The aim of the study was to ivestigate the potential association between PNP, sexual dysfunction, and physical activity behavior.Methods: Ninety-three patients with PNP of the feet and/or hands were interviewed in August/September 2020 in a cross-sectional study regarding medical history, sexual dysfunction and functionality of the genital organs.Results: Thirty-one persons who participated in the survey provided seventeen evaluable questionnaires (four men, thirteen women). Nine women (69%) and three men (75%) reported sensory disorders of the genital organs. Three men (75%) had erectile dysfunction. All men who had sensory symptoms of the genital organs received chemotherapy, and one man also received immunotherapy. Eight women were sexually active. Five (63%) of them reported genital organ symptoms and mainly lubrication disorders. Four (80%) of the five sexually inactive women reported genital organ symptoms. Eight of the nine women with sensory symptoms of the genital organs received chemotherapy, and one woman received immunotherapy. Discussion: Our limited data suggest genital organ sensory symptoms in chemotherapy and immunotherapy patients. Genital organ symptoms do not appear to be directly related to sexual dysfunction, and the association between PNP and genital organ symptoms appears to be more pronounced in sexually inactive women. Chemotherapy could cause sensory symptoms of the genital organs and sexual dysfunction by damaging genital organ nerve fibers. Chemotherapy and anti-hormone therapy (AHT) could trigger a disturbance of the hormone balance, which in turn could be causative for sexual dysfunction. It remains open whether the cause of these disorders is the symptomatology of the genital organs or the altered hormone balance. The significance of the results is limited due to the small number of cases. To our knowledge, this study is the first of its kind in cancer patients and allows a better understanding of the association between PNP, sensory symptoms of the genital organs, and sexual dysfunction. Conclusion: In order to be able to narrow down the cause of these initial observations in cancer patients more precisely, larger studies are needed that can relate the influence of cancer therapy-induced PNP, physical activity level and hormone balance to sensory symptoms of the genital organs and sexual dysfunction. The methodology of further studies should take into account the frequent problem of low response rates in surveys on sexuality.http://www.egms.de/static/en/journals/gms/2023-21/000322.shtmlperipheral neuropathygenital organssexual dysfunctionphysical activityoncologyexercise therapy |
| spellingShingle | Reimer, Nadine Brodesser, Dirk Ratiu, Dominik Zubac, Damir Lehmann, Helmar C. Baumann, Freerk T. Initial observations on sexual dysfunction as a symptom of chemotherapy-induced peripheral neuropathy GMS German Medical Science peripheral neuropathy genital organs sexual dysfunction physical activity oncology exercise therapy |
| title | Initial observations on sexual dysfunction as a symptom of chemotherapy-induced peripheral neuropathy |
| title_full | Initial observations on sexual dysfunction as a symptom of chemotherapy-induced peripheral neuropathy |
| title_fullStr | Initial observations on sexual dysfunction as a symptom of chemotherapy-induced peripheral neuropathy |
| title_full_unstemmed | Initial observations on sexual dysfunction as a symptom of chemotherapy-induced peripheral neuropathy |
| title_short | Initial observations on sexual dysfunction as a symptom of chemotherapy-induced peripheral neuropathy |
| title_sort | initial observations on sexual dysfunction as a symptom of chemotherapy induced peripheral neuropathy |
| topic | peripheral neuropathy genital organs sexual dysfunction physical activity oncology exercise therapy |
| url | http://www.egms.de/static/en/journals/gms/2023-21/000322.shtml |
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