Effect of <i>Eriobotrya japonica</i> Leaf Supplements on Allergic Rhinitis Symptoms and Skin Conditions in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study
<i>Eriobotrya japonica</i> (<i>E. japonica</i>) leaves have been used as an herbal traditional medicine in China and Japan owing to their anti-inflammatory and protective effects against skin conditions and allergy symptoms. These beneficial effects are likely mediated by the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Allergies |
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| Online Access: | https://www.mdpi.com/2313-5786/3/4/13 |
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| author | Masumi Nagae Maki Nagata Masako Matsumoto Naomichi Takemoto Yhiya Amen Dongmei Wang Yuri Yoshimitsu Kuniyoshi Shimizu |
| author_facet | Masumi Nagae Maki Nagata Masako Matsumoto Naomichi Takemoto Yhiya Amen Dongmei Wang Yuri Yoshimitsu Kuniyoshi Shimizu |
| author_sort | Masumi Nagae |
| collection | DOAJ |
| description | <i>Eriobotrya japonica</i> (<i>E. japonica</i>) leaves have been used as an herbal traditional medicine in China and Japan owing to their anti-inflammatory and protective effects against skin conditions and allergy symptoms. These beneficial effects are likely mediated by the various triterpenoids present in <i>E. japonica</i> leaves. However, the efficacy of <i>E. japonica</i> leaves in the treatment of allergic rhinitis has not been evaluated in humans. Therefore, in the present study, a randomized, controlled, double-blind trial was performed on healthy adults of age >20 (<i>n</i> = 27) who were randomly assigned to receive either 2.5 g of placebo or <i>E. japonica</i> leaf supplements once daily for 4 weeks. The Japanese Allergic Rhinitis Quality of Life Standard Questionnaire (JRQLQ), dermatological allergy symptoms, Dermatology Life Quality Index, and skin condition parameters were assessed at baseline and after 4 weeks. Significant differences were observed in the variability of the itchy nose, itchy eyes, and eye symptoms between the <i>E. japonica</i> supplementation and placebo groups after 4 weeks. Arm skin transepidermal water loss was improved only in the <i>E. japonica</i> supplementation group. This study suggests that <i>E. japonica</i> leaves can be used as a functional food ingredient to relieve allergic symptoms. |
| first_indexed | 2024-03-08T21:03:38Z |
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| id | doaj.art-7d8f63c9ba1f46f69168b012e7532e42 |
| institution | Directory Open Access Journal |
| issn | 2313-5786 |
| language | English |
| last_indexed | 2024-03-08T21:03:38Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Allergies |
| spelling | doaj.art-7d8f63c9ba1f46f69168b012e7532e422023-12-22T13:47:07ZengMDPI AGAllergies2313-57862023-10-013420221910.3390/allergies3040013Effect of <i>Eriobotrya japonica</i> Leaf Supplements on Allergic Rhinitis Symptoms and Skin Conditions in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled StudyMasumi Nagae0Maki Nagata1Masako Matsumoto2Naomichi Takemoto3Yhiya Amen4Dongmei Wang5Yuri Yoshimitsu6Kuniyoshi Shimizu7Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, JapanFaculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, JapanFaculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, JapanFaculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, JapanFaculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, JapanFaculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, JapanFaculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, JapanFaculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan<i>Eriobotrya japonica</i> (<i>E. japonica</i>) leaves have been used as an herbal traditional medicine in China and Japan owing to their anti-inflammatory and protective effects against skin conditions and allergy symptoms. These beneficial effects are likely mediated by the various triterpenoids present in <i>E. japonica</i> leaves. However, the efficacy of <i>E. japonica</i> leaves in the treatment of allergic rhinitis has not been evaluated in humans. Therefore, in the present study, a randomized, controlled, double-blind trial was performed on healthy adults of age >20 (<i>n</i> = 27) who were randomly assigned to receive either 2.5 g of placebo or <i>E. japonica</i> leaf supplements once daily for 4 weeks. The Japanese Allergic Rhinitis Quality of Life Standard Questionnaire (JRQLQ), dermatological allergy symptoms, Dermatology Life Quality Index, and skin condition parameters were assessed at baseline and after 4 weeks. Significant differences were observed in the variability of the itchy nose, itchy eyes, and eye symptoms between the <i>E. japonica</i> supplementation and placebo groups after 4 weeks. Arm skin transepidermal water loss was improved only in the <i>E. japonica</i> supplementation group. This study suggests that <i>E. japonica</i> leaves can be used as a functional food ingredient to relieve allergic symptoms.https://www.mdpi.com/2313-5786/3/4/13<i>Eriobotrya japonica</i>triterpenoidsursolic acidmaslinic acidoleanolic acidcorosolic acid |
| spellingShingle | Masumi Nagae Maki Nagata Masako Matsumoto Naomichi Takemoto Yhiya Amen Dongmei Wang Yuri Yoshimitsu Kuniyoshi Shimizu Effect of <i>Eriobotrya japonica</i> Leaf Supplements on Allergic Rhinitis Symptoms and Skin Conditions in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study Allergies <i>Eriobotrya japonica</i> triterpenoids ursolic acid maslinic acid oleanolic acid corosolic acid |
| title | Effect of <i>Eriobotrya japonica</i> Leaf Supplements on Allergic Rhinitis Symptoms and Skin Conditions in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study |
| title_full | Effect of <i>Eriobotrya japonica</i> Leaf Supplements on Allergic Rhinitis Symptoms and Skin Conditions in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study |
| title_fullStr | Effect of <i>Eriobotrya japonica</i> Leaf Supplements on Allergic Rhinitis Symptoms and Skin Conditions in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study |
| title_full_unstemmed | Effect of <i>Eriobotrya japonica</i> Leaf Supplements on Allergic Rhinitis Symptoms and Skin Conditions in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study |
| title_short | Effect of <i>Eriobotrya japonica</i> Leaf Supplements on Allergic Rhinitis Symptoms and Skin Conditions in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study |
| title_sort | effect of i eriobotrya japonica i leaf supplements on allergic rhinitis symptoms and skin conditions in healthy adults a randomized double blind placebo controlled study |
| topic | <i>Eriobotrya japonica</i> triterpenoids ursolic acid maslinic acid oleanolic acid corosolic acid |
| url | https://www.mdpi.com/2313-5786/3/4/13 |
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