The serotonin 1A receptor C(-1019)G polymorphism in relation to suicide attempt
<p>Abstract</p> <p>Background</p> <p>Serotonergic neurotransmission has been implicated in suicidal behavior. Association between suicidal completers and a regulatory C(-1019)G polymorphism (rs6295) in the serotonin 1A receptor (HTR1A) gene was previously reported, wher...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2006-04-01
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| Series: | Behavioral and Brain Functions |
| Online Access: | http://www.behavioralandbrainfunctions.com/content/2/1/14 |
| _version_ | 1818474221231144960 |
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| author | Rozanov Vsevolod Sokolowski Marcus Geijer Thomas Wasserman Danuta Wasserman Jerzy |
| author_facet | Rozanov Vsevolod Sokolowski Marcus Geijer Thomas Wasserman Danuta Wasserman Jerzy |
| author_sort | Rozanov Vsevolod |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Serotonergic neurotransmission has been implicated in suicidal behavior. Association between suicidal completers and a regulatory C(-1019)G polymorphism (rs6295) in the serotonin 1A receptor (HTR1A) gene was previously reported, whereas a following study showed no association in a sample of suicide attempters.</p> <p>Methods</p> <p>The involvement of the implicated G-allele of the 5-HTR1A C(-1019)G polymorphism (rs6295) was analyzed with the transmission disequilibrium test (TDT) in a sample of 272 suicide attempter families.</p> <p>Results</p> <p>No overtransmission of the G-allele was found in the entire sample of suicide attempters (p = 0.1460; n = 272 trios). However, a strong trend for overtransmission of the G-allele was observed in a sub-sample selected for a high level of previous traumatic and/or stressful life events prior to the suicide attempt (p = 0.0630, two-tail; n = 94 trios).</p> <p>Conclusion</p> <p>The current results show that variation at the rs6295 polymorphism of the HTR1A gene is not associated with suicide attempts generally. However, the results indicate a possible role of the G-allele in suicidal behavior in connection with high exposure to traumatic and/or stressful life events, which is in need of future investigation.</p> |
| first_indexed | 2024-04-14T04:34:00Z |
| format | Article |
| id | doaj.art-7d9165ba1e67441890c0a773829b5eee |
| institution | Directory Open Access Journal |
| issn | 1744-9081 |
| language | English |
| last_indexed | 2024-04-14T04:34:00Z |
| publishDate | 2006-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Behavioral and Brain Functions |
| spelling | doaj.art-7d9165ba1e67441890c0a773829b5eee2022-12-22T02:11:56ZengBMCBehavioral and Brain Functions1744-90812006-04-01211410.1186/1744-9081-2-14The serotonin 1A receptor C(-1019)G polymorphism in relation to suicide attemptRozanov VsevolodSokolowski MarcusGeijer ThomasWasserman DanutaWasserman Jerzy<p>Abstract</p> <p>Background</p> <p>Serotonergic neurotransmission has been implicated in suicidal behavior. Association between suicidal completers and a regulatory C(-1019)G polymorphism (rs6295) in the serotonin 1A receptor (HTR1A) gene was previously reported, whereas a following study showed no association in a sample of suicide attempters.</p> <p>Methods</p> <p>The involvement of the implicated G-allele of the 5-HTR1A C(-1019)G polymorphism (rs6295) was analyzed with the transmission disequilibrium test (TDT) in a sample of 272 suicide attempter families.</p> <p>Results</p> <p>No overtransmission of the G-allele was found in the entire sample of suicide attempters (p = 0.1460; n = 272 trios). However, a strong trend for overtransmission of the G-allele was observed in a sub-sample selected for a high level of previous traumatic and/or stressful life events prior to the suicide attempt (p = 0.0630, two-tail; n = 94 trios).</p> <p>Conclusion</p> <p>The current results show that variation at the rs6295 polymorphism of the HTR1A gene is not associated with suicide attempts generally. However, the results indicate a possible role of the G-allele in suicidal behavior in connection with high exposure to traumatic and/or stressful life events, which is in need of future investigation.</p>http://www.behavioralandbrainfunctions.com/content/2/1/14 |
| spellingShingle | Rozanov Vsevolod Sokolowski Marcus Geijer Thomas Wasserman Danuta Wasserman Jerzy The serotonin 1A receptor C(-1019)G polymorphism in relation to suicide attempt Behavioral and Brain Functions |
| title | The serotonin 1A receptor C(-1019)G polymorphism in relation to suicide attempt |
| title_full | The serotonin 1A receptor C(-1019)G polymorphism in relation to suicide attempt |
| title_fullStr | The serotonin 1A receptor C(-1019)G polymorphism in relation to suicide attempt |
| title_full_unstemmed | The serotonin 1A receptor C(-1019)G polymorphism in relation to suicide attempt |
| title_short | The serotonin 1A receptor C(-1019)G polymorphism in relation to suicide attempt |
| title_sort | serotonin 1a receptor c 1019 g polymorphism in relation to suicide attempt |
| url | http://www.behavioralandbrainfunctions.com/content/2/1/14 |
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