Fully Automated Synthesis Carbon-11 Radiopharmaceuticals using Home Made PET-MV-2-F Module Assembled the Methyl Iodide Module
Combined the home made PET-MV-2-IT module with carbon-11 methyl iodide module, it was used for synthesis of carbon-11 radiotracers. Methylation agent 11C-CH3-Triflate was synthesized with methyl iodide module. The11C-CH3-Triflate was bubbled to the second reaction vessels in PET-MV-2-IT module,...
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| Format: | Article |
| Language: | zho |
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Editorial Board of Journal of Isotopes
2014-02-01
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| Series: | Journal of Isotopes |
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| Online Access: | http://www.tws.org.cn/CN/10.7538/tws.2014.27.01.0028 |
| Summary: | Combined the home made PET-MV-2-IT module with carbon-11 methyl iodide module, it was used for synthesis of carbon-11 radiotracers. Methylation agent 11C-CH3-Triflate was synthesized with methyl iodide module. The11C-CH3-Triflate was bubbled to the second reaction vessels in PET-MV-2-IT module, which the precursors were stored. The productions were purified by semi-HPLC and solid phase extraction (SPE) to get the final radiopharmaceuticals. There are four carbon-11 radiopharmaceuticals were synthesized with the method, which it were 11C-Raclopride,11C-PIB,11C-DASB and 11C-PK11195,and synthesis yields were （38.2±4.5）% (n=10），（68.4±3.2）% (n=12), （52.4±5.5）%(n=4）and （45.6±7.1）% (n=8）respectively. All productions radiochemical purity were over 95%. Assembled the methyl iodide module with PET-MV-2-F, which it had semi-HPLC, we can synthesize most carbon-11 radiopharmaceuticals for clinical used. |
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| ISSN: | 1000-7512 1000-7512 |