Cancer Stem Cells: Significance in Origin, Pathogenesis and Treatment of Glioblastoma
Cancer stem cells (CSCs), known also as tumor-initiating cells, are quiescent, pluripotent, self-renewing neoplastic cells that were first identified in hematologic tumors and soon after in solid malignancies. CSCs have attracted remarkable research interest due to their role in tumor resistance to...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/3/621 |
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| author | Karina Biserova Arvids Jakovlevs Romans Uljanovs Ilze Strumfa |
| author_facet | Karina Biserova Arvids Jakovlevs Romans Uljanovs Ilze Strumfa |
| author_sort | Karina Biserova |
| collection | DOAJ |
| description | Cancer stem cells (CSCs), known also as tumor-initiating cells, are quiescent, pluripotent, self-renewing neoplastic cells that were first identified in hematologic tumors and soon after in solid malignancies. CSCs have attracted remarkable research interest due to their role in tumor resistance to chemotherapy and radiation treatment as well as recurrence. Extensive research has been devoted to the role of CSCs in glioblastoma multiforme (GBM), the most common primary brain tumor in adults, which is characterized by a dismal prognosis because of its aggressive course and poor response to treatment. The aim of the current paper is to provide an overview of current knowledge on the role of cancer stem cells in the pathogenesis and treatment resistance of glioblastoma. The six regulatory mechanisms of glioma stem cells (GSCs)—tumor microenvironment, niche concept, metabolism, immunity, genetics, and epigenetics—are reviewed. The molecular markers used to identify GSCs are described. The role of GSCs in the treatment resistance of glioblastoma is reviewed, along with future treatment options targeting GSCs. Stem cells of glioblastoma thus represent both a driving mechanism of major treatment difficulties and a possible target for more effective future approaches. |
| first_indexed | 2024-03-10T13:19:22Z |
| format | Article |
| id | doaj.art-7d93c6d9d3914c9ab69d10fb51fe5ff0 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T13:19:22Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-7d93c6d9d3914c9ab69d10fb51fe5ff02023-11-21T10:07:13ZengMDPI AGCells2073-44092021-03-0110362110.3390/cells10030621Cancer Stem Cells: Significance in Origin, Pathogenesis and Treatment of GlioblastomaKarina Biserova0Arvids Jakovlevs1Romans Uljanovs2Ilze Strumfa3Faculty of Residency, Riga Stradins University, 16 Dzirciema Street, LV-1007 Riga, LatviaDepartment of Pathology, Riga Stradins University, 16 Dzirciema Street, LV-1007 Riga, LatviaDepartment of Pathology, Riga Stradins University, 16 Dzirciema Street, LV-1007 Riga, LatviaDepartment of Pathology, Riga Stradins University, 16 Dzirciema Street, LV-1007 Riga, LatviaCancer stem cells (CSCs), known also as tumor-initiating cells, are quiescent, pluripotent, self-renewing neoplastic cells that were first identified in hematologic tumors and soon after in solid malignancies. CSCs have attracted remarkable research interest due to their role in tumor resistance to chemotherapy and radiation treatment as well as recurrence. Extensive research has been devoted to the role of CSCs in glioblastoma multiforme (GBM), the most common primary brain tumor in adults, which is characterized by a dismal prognosis because of its aggressive course and poor response to treatment. The aim of the current paper is to provide an overview of current knowledge on the role of cancer stem cells in the pathogenesis and treatment resistance of glioblastoma. The six regulatory mechanisms of glioma stem cells (GSCs)—tumor microenvironment, niche concept, metabolism, immunity, genetics, and epigenetics—are reviewed. The molecular markers used to identify GSCs are described. The role of GSCs in the treatment resistance of glioblastoma is reviewed, along with future treatment options targeting GSCs. Stem cells of glioblastoma thus represent both a driving mechanism of major treatment difficulties and a possible target for more effective future approaches.https://www.mdpi.com/2073-4409/10/3/621glioblastomaglioma stem cellsgliomacancercancer stem cells |
| spellingShingle | Karina Biserova Arvids Jakovlevs Romans Uljanovs Ilze Strumfa Cancer Stem Cells: Significance in Origin, Pathogenesis and Treatment of Glioblastoma Cells glioblastoma glioma stem cells glioma cancer cancer stem cells |
| title | Cancer Stem Cells: Significance in Origin, Pathogenesis and Treatment of Glioblastoma |
| title_full | Cancer Stem Cells: Significance in Origin, Pathogenesis and Treatment of Glioblastoma |
| title_fullStr | Cancer Stem Cells: Significance in Origin, Pathogenesis and Treatment of Glioblastoma |
| title_full_unstemmed | Cancer Stem Cells: Significance in Origin, Pathogenesis and Treatment of Glioblastoma |
| title_short | Cancer Stem Cells: Significance in Origin, Pathogenesis and Treatment of Glioblastoma |
| title_sort | cancer stem cells significance in origin pathogenesis and treatment of glioblastoma |
| topic | glioblastoma glioma stem cells glioma cancer cancer stem cells |
| url | https://www.mdpi.com/2073-4409/10/3/621 |
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