Cholesterol-induced LRP3 downregulation promotes cartilage degeneration in osteoarthritis by targeting Syndecan-4

Cholesterol-induced LRP3 downregulation promotes cartilage degeneration in osteoarthritis by targeting Syndecan-4

This study demonstrates a role of cholesterol metabolism-related gene, Lrp3, in cartilage degeneration and osteoarthritis pathogenesis. LRP3 positively regulates cartilage extracellular matrix metabolism by targeting syndecan-4 via Ras signalling, implicating the cholesterol-LRP3-SDC4 axis in osteoa...

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Bibliographic Details
Main Authors: Chenxi Cao, Yuanyuan Shi, Xin Zhang, Qi Li, Jiahao Zhang, Fengyuan Zhao, Qingyang Meng, Wenli Dai, Zhenlong Liu, Wenqiang Yan, Xiaoning Duan, Jiying Zhang, Xin Fu, Jin Cheng, Xiaoqing Hu, Yingfang Ao
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34830-4

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