Neutrophil-to-lymphocyte ratio may predict clinical relapse in ulcerative colitis patients with mucosal healing
Endoscopic mucosal healing (MH) is an important treatment goal for patients with ulcerative colitis (UC). The neutrophil-to-lymphocyte ratio (NLR) reflects systemic inflammation and has been reported to be a useful predictive marker for UC. This study aimed to evaluate the clinical utility of the NL...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9836288/?tool=EBI |
| _version_ | 1828063278737129472 |
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| author | Noriyuki Kurimoto Yu Nishida Shuhei Hosomi Shigehiro Itani Yumie Kobayashi Rieko Nakata Masaki Ominami Yuji Nadatani Shusei Fukunaga Koji Otani Fumio Tanaka Yasuaki Nagami Koichi Taira Noriko Kamata Yasuhiro Fujiwara |
| author_facet | Noriyuki Kurimoto Yu Nishida Shuhei Hosomi Shigehiro Itani Yumie Kobayashi Rieko Nakata Masaki Ominami Yuji Nadatani Shusei Fukunaga Koji Otani Fumio Tanaka Yasuaki Nagami Koichi Taira Noriko Kamata Yasuhiro Fujiwara |
| author_sort | Noriyuki Kurimoto |
| collection | DOAJ |
| description | Endoscopic mucosal healing (MH) is an important treatment goal for patients with ulcerative colitis (UC). The neutrophil-to-lymphocyte ratio (NLR) reflects systemic inflammation and has been reported to be a useful predictive marker for UC. This study aimed to evaluate the clinical utility of the NLR for predicting clinical relapse in UC patients with MH. We retrospectively enrolled patients with UC who underwent colonoscopy at the Osaka City University Hospital between January 2010 and December 2010, whose Mayo Endoscopic Subscore was 0 or 1. The correlation between the incidence of relapse and demographic factors, including the NLR, was analyzed. We included 129 patients in the present study. The median NLR at the time of endoscopy was 1.98, and differences in the high NLR group and the low NLR group were compared. During a median follow-up period of 46.4 months, 58 patients (45.0%) experienced relapse. The cumulative relapse-free rate was significantly higher in the low NLR group than in the high NLR group (P = 0.03, log-rank test). Multivariate analysis identified high NLR as an independent prognostic factor for clinical relapse (hazard ratio, 1.74; 95% confidence interval, 1.02–2.98; P = 0.04). NLR is a novel and useful predictor of clinical relapse in UC patients with MH, and it can potentially be a strong indicator to determine the appropriate treatment strategy and decision-making in clinical practice. |
| first_indexed | 2024-04-10T22:40:42Z |
| format | Article |
| id | doaj.art-7d994dad4b0c436d915133ba7c6832ae |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-10T22:40:42Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-7d994dad4b0c436d915133ba7c6832ae2023-01-16T05:31:17ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01181Neutrophil-to-lymphocyte ratio may predict clinical relapse in ulcerative colitis patients with mucosal healingNoriyuki KurimotoYu NishidaShuhei HosomiShigehiro ItaniYumie KobayashiRieko NakataMasaki OminamiYuji NadataniShusei FukunagaKoji OtaniFumio TanakaYasuaki NagamiKoichi TairaNoriko KamataYasuhiro FujiwaraEndoscopic mucosal healing (MH) is an important treatment goal for patients with ulcerative colitis (UC). The neutrophil-to-lymphocyte ratio (NLR) reflects systemic inflammation and has been reported to be a useful predictive marker for UC. This study aimed to evaluate the clinical utility of the NLR for predicting clinical relapse in UC patients with MH. We retrospectively enrolled patients with UC who underwent colonoscopy at the Osaka City University Hospital between January 2010 and December 2010, whose Mayo Endoscopic Subscore was 0 or 1. The correlation between the incidence of relapse and demographic factors, including the NLR, was analyzed. We included 129 patients in the present study. The median NLR at the time of endoscopy was 1.98, and differences in the high NLR group and the low NLR group were compared. During a median follow-up period of 46.4 months, 58 patients (45.0%) experienced relapse. The cumulative relapse-free rate was significantly higher in the low NLR group than in the high NLR group (P = 0.03, log-rank test). Multivariate analysis identified high NLR as an independent prognostic factor for clinical relapse (hazard ratio, 1.74; 95% confidence interval, 1.02–2.98; P = 0.04). NLR is a novel and useful predictor of clinical relapse in UC patients with MH, and it can potentially be a strong indicator to determine the appropriate treatment strategy and decision-making in clinical practice.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9836288/?tool=EBI |
| spellingShingle | Noriyuki Kurimoto Yu Nishida Shuhei Hosomi Shigehiro Itani Yumie Kobayashi Rieko Nakata Masaki Ominami Yuji Nadatani Shusei Fukunaga Koji Otani Fumio Tanaka Yasuaki Nagami Koichi Taira Noriko Kamata Yasuhiro Fujiwara Neutrophil-to-lymphocyte ratio may predict clinical relapse in ulcerative colitis patients with mucosal healing PLoS ONE |
| title | Neutrophil-to-lymphocyte ratio may predict clinical relapse in ulcerative colitis patients with mucosal healing |
| title_full | Neutrophil-to-lymphocyte ratio may predict clinical relapse in ulcerative colitis patients with mucosal healing |
| title_fullStr | Neutrophil-to-lymphocyte ratio may predict clinical relapse in ulcerative colitis patients with mucosal healing |
| title_full_unstemmed | Neutrophil-to-lymphocyte ratio may predict clinical relapse in ulcerative colitis patients with mucosal healing |
| title_short | Neutrophil-to-lymphocyte ratio may predict clinical relapse in ulcerative colitis patients with mucosal healing |
| title_sort | neutrophil to lymphocyte ratio may predict clinical relapse in ulcerative colitis patients with mucosal healing |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9836288/?tool=EBI |
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