Allosteric modulation of chemoattractant receptors

Allosteric modulation of chemoattractant receptors

Chemoattractants control selective leukocyte homing via interactions with a dedicated family of related GPCR. Emerging evidence indicates that the signalling activity of these receptors, as for other GPCR, is influenced by allosteric modulators, which interact with the receptor in a binding site dis...

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Bibliographic Details
Main Authors:	Maria Candida Cesta, Marcello eAllegretti, Massimo eLocati
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2016-05-01
Series:	Frontiers in Immunology
Subjects:	chemoattractant chemokine receptor Leukocyte recruitment functional selectivity biased signalling
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00170/full

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