Recent Developments in 3D-(Bio)printed Hydrogels as Wound Dressings
Wound healing is a physiological process occurring after the onset of a skin lesion aiming to reconstruct the dermal barrier between the external environment and the body. Depending on the nature and duration of the healing process, wounds are classified as acute (e.g., trauma, surgical wounds) and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/10/2/147 |
| _version_ | 1797298148052303872 |
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| author | Olga Kammona Evgenia Tsanaktsidou Costas Kiparissides |
| author_facet | Olga Kammona Evgenia Tsanaktsidou Costas Kiparissides |
| author_sort | Olga Kammona |
| collection | DOAJ |
| description | Wound healing is a physiological process occurring after the onset of a skin lesion aiming to reconstruct the dermal barrier between the external environment and the body. Depending on the nature and duration of the healing process, wounds are classified as acute (e.g., trauma, surgical wounds) and chronic (e.g., diabetic ulcers) wounds. The latter take several months to heal or do not heal (non-healing chronic wounds), are usually prone to microbial infection and represent an important source of morbidity since they affect millions of people worldwide. Typical wound treatments comprise surgical (e.g., debridement, skin grafts/flaps) and non-surgical (e.g., topical formulations, wound dressings) methods. Modern experimental approaches include among others three dimensional (3D)-(bio)printed wound dressings. The present paper reviews recently developed 3D (bio)printed hydrogels for wound healing applications, especially focusing on the results of their in vitro and in vivo assessment. The advanced hydrogel constructs were printed using different types of bioinks (e.g., natural and/or synthetic polymers and their mixtures with biological materials) and printing methods (e.g., extrusion, digital light processing, coaxial microfluidic bioprinting, etc.) and incorporated various bioactive agents (e.g., growth factors, antibiotics, antibacterial agents, nanoparticles, etc.) and/or cells (e.g., dermal fibroblasts, keratinocytes, mesenchymal stem cells, endothelial cells, etc.). |
| first_indexed | 2024-03-07T22:31:43Z |
| format | Article |
| id | doaj.art-7d9a058db3be493a858aea04baff4d94 |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-07T22:31:43Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-7d9a058db3be493a858aea04baff4d942024-02-23T15:17:36ZengMDPI AGGels2310-28612024-02-0110214710.3390/gels10020147Recent Developments in 3D-(Bio)printed Hydrogels as Wound DressingsOlga Kammona0Evgenia Tsanaktsidou1Costas Kiparissides2Chemical Process & Energy Resources Research Institute, Centre for Research and Technology Hellas, P.O. Box 60361, 57001 Thessaloniki, GreeceChemical Process & Energy Resources Research Institute, Centre for Research and Technology Hellas, P.O. Box 60361, 57001 Thessaloniki, GreeceChemical Process & Energy Resources Research Institute, Centre for Research and Technology Hellas, P.O. Box 60361, 57001 Thessaloniki, GreeceWound healing is a physiological process occurring after the onset of a skin lesion aiming to reconstruct the dermal barrier between the external environment and the body. Depending on the nature and duration of the healing process, wounds are classified as acute (e.g., trauma, surgical wounds) and chronic (e.g., diabetic ulcers) wounds. The latter take several months to heal or do not heal (non-healing chronic wounds), are usually prone to microbial infection and represent an important source of morbidity since they affect millions of people worldwide. Typical wound treatments comprise surgical (e.g., debridement, skin grafts/flaps) and non-surgical (e.g., topical formulations, wound dressings) methods. Modern experimental approaches include among others three dimensional (3D)-(bio)printed wound dressings. The present paper reviews recently developed 3D (bio)printed hydrogels for wound healing applications, especially focusing on the results of their in vitro and in vivo assessment. The advanced hydrogel constructs were printed using different types of bioinks (e.g., natural and/or synthetic polymers and their mixtures with biological materials) and printing methods (e.g., extrusion, digital light processing, coaxial microfluidic bioprinting, etc.) and incorporated various bioactive agents (e.g., growth factors, antibiotics, antibacterial agents, nanoparticles, etc.) and/or cells (e.g., dermal fibroblasts, keratinocytes, mesenchymal stem cells, endothelial cells, etc.).https://www.mdpi.com/2310-2861/10/2/147hydrogelswound healing3D bioprintingwound dressingspolymers |
| spellingShingle | Olga Kammona Evgenia Tsanaktsidou Costas Kiparissides Recent Developments in 3D-(Bio)printed Hydrogels as Wound Dressings Gels hydrogels wound healing 3D bioprinting wound dressings polymers |
| title | Recent Developments in 3D-(Bio)printed Hydrogels as Wound Dressings |
| title_full | Recent Developments in 3D-(Bio)printed Hydrogels as Wound Dressings |
| title_fullStr | Recent Developments in 3D-(Bio)printed Hydrogels as Wound Dressings |
| title_full_unstemmed | Recent Developments in 3D-(Bio)printed Hydrogels as Wound Dressings |
| title_short | Recent Developments in 3D-(Bio)printed Hydrogels as Wound Dressings |
| title_sort | recent developments in 3d bio printed hydrogels as wound dressings |
| topic | hydrogels wound healing 3D bioprinting wound dressings polymers |
| url | https://www.mdpi.com/2310-2861/10/2/147 |
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