Anti-oxidant and anti-hyperlipidemic effects of cordycepin-rich Cordyceps militaris in a Sprague–Dawley rat model of alcohol-induced hyperlipidemia and oxidative stress
Abstract Hyperlipidemia is involved in serious cardiovascular disease, however, synthetic drugs to reduce lipid contents in blood stream have been found to induce serious side effects. In the current study, we compared anti-oxidant and anti-hyperlipidemic effect of Paecilomyces japonica (PJ), Cordyc...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-06-01
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| Series: | Bioresources and Bioprocessing |
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| Online Access: | http://link.springer.com/article/10.1186/s40643-020-00323-9 |
| _version_ | 1818870543570436096 |
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| author | Hee-Young Ahn Hyun-Dong Cho Young-Su Cho |
| author_facet | Hee-Young Ahn Hyun-Dong Cho Young-Su Cho |
| author_sort | Hee-Young Ahn |
| collection | DOAJ |
| description | Abstract Hyperlipidemia is involved in serious cardiovascular disease, however, synthetic drugs to reduce lipid contents in blood stream have been found to induce serious side effects. In the current study, we compared anti-oxidant and anti-hyperlipidemic effect of Paecilomyces japonica (PJ), Cordyceps militaris (CM) and cordycepin-rich Cordyceps militaris (CMα) in rats induced alcoholic hyperlipidemia (AIH) and oxidative stress. The experimental groups were divided in N (water), C (30% alcohol), PJ (30% alcohol + 3% PJ powder), CM (30% alcohol + 3% CM powder), CMα (30% alcohol + 3% CMα powder) and SM [30% alcohol + 0.1% silymarin (SM)]. Compared to C group, supplementation of PJ, CM, CMα and SM slightly alleviated the increased weight ratio of liver and kidney in the alcohol-treated rats. In addition, a significant or slight reduction was identified in total lipid, total cholesterol and HDL-cholesterol levels in the rats receiving PJ, CM and CMα as compared with C group. Administration of PJ, CM and CMα also blocked alcohol-induced lipid peroxidation via a decrease of malondialdehyde (MDA), and activated anti-oxidant enzyme, glutathione (GSH), in serum and various organ tissues. Overall, cordycepin-rich CMα showed highest anti-oxidant and anti-hyperlipidemia effect under chronic alcoholic damage. Our results indicate that CMα might be useful in inhibiting the oxidation and hyperlipidemia in alcohol-induced hepatic disease possibly because of potential anti-oxidative and anti-hyperlipidemic activities of cordycepin. |
| first_indexed | 2024-12-19T12:08:42Z |
| format | Article |
| id | doaj.art-7d9b599a0ca14a61b0cf136d30ed4da9 |
| institution | Directory Open Access Journal |
| issn | 2197-4365 |
| language | English |
| last_indexed | 2024-12-19T12:08:42Z |
| publishDate | 2020-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Bioresources and Bioprocessing |
| spelling | doaj.art-7d9b599a0ca14a61b0cf136d30ed4da92022-12-21T20:22:17ZengSpringerOpenBioresources and Bioprocessing2197-43652020-06-01711910.1186/s40643-020-00323-9Anti-oxidant and anti-hyperlipidemic effects of cordycepin-rich Cordyceps militaris in a Sprague–Dawley rat model of alcohol-induced hyperlipidemia and oxidative stressHee-Young Ahn0Hyun-Dong Cho1Young-Su Cho2Department of Biotechnology, Dong-A UniversityDepartment of Food Science, University of ArkansasDepartment of Biotechnology, Dong-A UniversityAbstract Hyperlipidemia is involved in serious cardiovascular disease, however, synthetic drugs to reduce lipid contents in blood stream have been found to induce serious side effects. In the current study, we compared anti-oxidant and anti-hyperlipidemic effect of Paecilomyces japonica (PJ), Cordyceps militaris (CM) and cordycepin-rich Cordyceps militaris (CMα) in rats induced alcoholic hyperlipidemia (AIH) and oxidative stress. The experimental groups were divided in N (water), C (30% alcohol), PJ (30% alcohol + 3% PJ powder), CM (30% alcohol + 3% CM powder), CMα (30% alcohol + 3% CMα powder) and SM [30% alcohol + 0.1% silymarin (SM)]. Compared to C group, supplementation of PJ, CM, CMα and SM slightly alleviated the increased weight ratio of liver and kidney in the alcohol-treated rats. In addition, a significant or slight reduction was identified in total lipid, total cholesterol and HDL-cholesterol levels in the rats receiving PJ, CM and CMα as compared with C group. Administration of PJ, CM and CMα also blocked alcohol-induced lipid peroxidation via a decrease of malondialdehyde (MDA), and activated anti-oxidant enzyme, glutathione (GSH), in serum and various organ tissues. Overall, cordycepin-rich CMα showed highest anti-oxidant and anti-hyperlipidemia effect under chronic alcoholic damage. Our results indicate that CMα might be useful in inhibiting the oxidation and hyperlipidemia in alcohol-induced hepatic disease possibly because of potential anti-oxidative and anti-hyperlipidemic activities of cordycepin.http://link.springer.com/article/10.1186/s40643-020-00323-9Cordycepin-rich Cordyceps militarisThiobarbituric acid-reactive substances (TBARS)Reduced glutathione (GSH)Oxidative stressAnti-hyperlipidemic activity |
| spellingShingle | Hee-Young Ahn Hyun-Dong Cho Young-Su Cho Anti-oxidant and anti-hyperlipidemic effects of cordycepin-rich Cordyceps militaris in a Sprague–Dawley rat model of alcohol-induced hyperlipidemia and oxidative stress Bioresources and Bioprocessing Cordycepin-rich Cordyceps militaris Thiobarbituric acid-reactive substances (TBARS) Reduced glutathione (GSH) Oxidative stress Anti-hyperlipidemic activity |
| title | Anti-oxidant and anti-hyperlipidemic effects of cordycepin-rich Cordyceps militaris in a Sprague–Dawley rat model of alcohol-induced hyperlipidemia and oxidative stress |
| title_full | Anti-oxidant and anti-hyperlipidemic effects of cordycepin-rich Cordyceps militaris in a Sprague–Dawley rat model of alcohol-induced hyperlipidemia and oxidative stress |
| title_fullStr | Anti-oxidant and anti-hyperlipidemic effects of cordycepin-rich Cordyceps militaris in a Sprague–Dawley rat model of alcohol-induced hyperlipidemia and oxidative stress |
| title_full_unstemmed | Anti-oxidant and anti-hyperlipidemic effects of cordycepin-rich Cordyceps militaris in a Sprague–Dawley rat model of alcohol-induced hyperlipidemia and oxidative stress |
| title_short | Anti-oxidant and anti-hyperlipidemic effects of cordycepin-rich Cordyceps militaris in a Sprague–Dawley rat model of alcohol-induced hyperlipidemia and oxidative stress |
| title_sort | anti oxidant and anti hyperlipidemic effects of cordycepin rich cordyceps militaris in a sprague dawley rat model of alcohol induced hyperlipidemia and oxidative stress |
| topic | Cordycepin-rich Cordyceps militaris Thiobarbituric acid-reactive substances (TBARS) Reduced glutathione (GSH) Oxidative stress Anti-hyperlipidemic activity |
| url | http://link.springer.com/article/10.1186/s40643-020-00323-9 |
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