Ferroptosis in inflammatory arthritis: A promising future
Ferroptosis is a kind of regulatory cell death (RCD) caused by iron accumulation and lipid peroxidation, which is characterized by mitochondrial morphological changes and has a complex regulatory network. Ferroptosis has been gradually emphasized in the pathogenesis of inflammatory arthritis. In thi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.955069/full |
| _version_ | 1811221822801182720 |
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| author | Siyuan Chang Mengshi Tang Bikui Zhang Daxiong Xiang Fen Li |
| author_facet | Siyuan Chang Mengshi Tang Bikui Zhang Daxiong Xiang Fen Li |
| author_sort | Siyuan Chang |
| collection | DOAJ |
| description | Ferroptosis is a kind of regulatory cell death (RCD) caused by iron accumulation and lipid peroxidation, which is characterized by mitochondrial morphological changes and has a complex regulatory network. Ferroptosis has been gradually emphasized in the pathogenesis of inflammatory arthritis. In this review, we summarized the relevant research on ferroptosis in various inflammatory arthritis including rheumatoid arthritis (RA), osteoarthritis, gout arthritis, and ankylosing spondylitis, and focused on the relationship between RA and ferroptosis. In patients with RA and animal models of RA, there was evidence of iron overload and lipid peroxidation, as well as mitochondrial dysfunction that may be associated with ferroptosis. Ferroptosis inducers have shown good application prospects in tumor therapy, and some anti-rheumatic drugs such as methotrexate and sulfasalazine have been shown to have ferroptosis modulating effects. These phenomena suggest that the role of ferroptosis in the pathogenesis of inflammatory arthritis will be worth further study. The development of therapeutic strategies targeting ferroptosis for patients with inflammatory arthritis may be a promising future. |
| first_indexed | 2024-04-12T08:05:47Z |
| format | Article |
| id | doaj.art-7d9c3afd966b43a78854a1fc6700fd53 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T08:05:47Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-7d9c3afd966b43a78854a1fc6700fd532022-12-22T03:41:10ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-07-011310.3389/fimmu.2022.955069955069Ferroptosis in inflammatory arthritis: A promising futureSiyuan Chang0Mengshi Tang1Bikui Zhang2Daxiong Xiang3Fen Li4Department of Rheumatology and Immunology, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Rheumatology and Immunology, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Pharmacy, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Pharmacy, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Rheumatology and Immunology, The Second Xiangya Hospital of Central South University, Changsha, ChinaFerroptosis is a kind of regulatory cell death (RCD) caused by iron accumulation and lipid peroxidation, which is characterized by mitochondrial morphological changes and has a complex regulatory network. Ferroptosis has been gradually emphasized in the pathogenesis of inflammatory arthritis. In this review, we summarized the relevant research on ferroptosis in various inflammatory arthritis including rheumatoid arthritis (RA), osteoarthritis, gout arthritis, and ankylosing spondylitis, and focused on the relationship between RA and ferroptosis. In patients with RA and animal models of RA, there was evidence of iron overload and lipid peroxidation, as well as mitochondrial dysfunction that may be associated with ferroptosis. Ferroptosis inducers have shown good application prospects in tumor therapy, and some anti-rheumatic drugs such as methotrexate and sulfasalazine have been shown to have ferroptosis modulating effects. These phenomena suggest that the role of ferroptosis in the pathogenesis of inflammatory arthritis will be worth further study. The development of therapeutic strategies targeting ferroptosis for patients with inflammatory arthritis may be a promising future.https://www.frontiersin.org/articles/10.3389/fimmu.2022.955069/fullferroptosisinflammatory arthritisiron accumulationlipid peroxidationcell death |
| spellingShingle | Siyuan Chang Mengshi Tang Bikui Zhang Daxiong Xiang Fen Li Ferroptosis in inflammatory arthritis: A promising future Frontiers in Immunology ferroptosis inflammatory arthritis iron accumulation lipid peroxidation cell death |
| title | Ferroptosis in inflammatory arthritis: A promising future |
| title_full | Ferroptosis in inflammatory arthritis: A promising future |
| title_fullStr | Ferroptosis in inflammatory arthritis: A promising future |
| title_full_unstemmed | Ferroptosis in inflammatory arthritis: A promising future |
| title_short | Ferroptosis in inflammatory arthritis: A promising future |
| title_sort | ferroptosis in inflammatory arthritis a promising future |
| topic | ferroptosis inflammatory arthritis iron accumulation lipid peroxidation cell death |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.955069/full |
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