Vascular Smooth Muscle Cells Phenotypic Switching in Cardiovascular Diseases
Vascular smooth muscle cells (VSMCs), the major cell type in the arterial vessel wall, have a contractile phenotype that maintains the normal vessel structure and function under physiological conditions. In response to stress or vascular injury, contractile VSMCs can switch to a less differentiated...
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MDPI AG
2022-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/24/4060 |
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| author | Hao-Yue Tang Ai-Qun Chen Huan Zhang Xiao-Fei Gao Xiang-Quan Kong Jun-Jie Zhang |
| author_facet | Hao-Yue Tang Ai-Qun Chen Huan Zhang Xiao-Fei Gao Xiang-Quan Kong Jun-Jie Zhang |
| author_sort | Hao-Yue Tang |
| collection | DOAJ |
| description | Vascular smooth muscle cells (VSMCs), the major cell type in the arterial vessel wall, have a contractile phenotype that maintains the normal vessel structure and function under physiological conditions. In response to stress or vascular injury, contractile VSMCs can switch to a less differentiated state (synthetic phenotype) to acquire the proliferative, migratory, and synthetic capabilities for tissue reparation. Imbalances in VSMCs phenotypic switching can result in a variety of cardiovascular diseases, including atherosclerosis, in-stent restenosis, aortic aneurysms, and vascular calcification. It is very important to identify the molecular mechanisms regulating VSMCs phenotypic switching to prevent and treat cardiovascular diseases with high morbidity and mortality. However, the key molecular mechanisms and signaling pathways participating in VSMCs phenotypic switching have still not been fully elucidated despite long-term efforts by cardiovascular researchers. In this review, we provide an updated summary of the recent studies and systematic knowledge of VSMCs phenotypic switching in atherosclerosis, in-stent restenosis, aortic aneurysms, and vascular calcification, which may help guide future research and provide novel insights into the prevention and treatment of related diseases. |
| first_indexed | 2024-03-09T17:12:27Z |
| format | Article |
| id | doaj.art-7d9cc0d3a3ad4e928c9d432d5189b1ed |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T17:12:27Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
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| spelling | doaj.art-7d9cc0d3a3ad4e928c9d432d5189b1ed2023-11-24T13:55:06ZengMDPI AGCells2073-44092022-12-011124406010.3390/cells11244060Vascular Smooth Muscle Cells Phenotypic Switching in Cardiovascular DiseasesHao-Yue Tang0Ai-Qun Chen1Huan Zhang2Xiao-Fei Gao3Xiang-Quan Kong4Jun-Jie Zhang5Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, No. 68 Changle Road, Nanjing 210006, ChinaDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, No. 68 Changle Road, Nanjing 210006, ChinaDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, No. 68 Changle Road, Nanjing 210006, ChinaDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, No. 68 Changle Road, Nanjing 210006, ChinaDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, No. 68 Changle Road, Nanjing 210006, ChinaDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, No. 68 Changle Road, Nanjing 210006, ChinaVascular smooth muscle cells (VSMCs), the major cell type in the arterial vessel wall, have a contractile phenotype that maintains the normal vessel structure and function under physiological conditions. In response to stress or vascular injury, contractile VSMCs can switch to a less differentiated state (synthetic phenotype) to acquire the proliferative, migratory, and synthetic capabilities for tissue reparation. Imbalances in VSMCs phenotypic switching can result in a variety of cardiovascular diseases, including atherosclerosis, in-stent restenosis, aortic aneurysms, and vascular calcification. It is very important to identify the molecular mechanisms regulating VSMCs phenotypic switching to prevent and treat cardiovascular diseases with high morbidity and mortality. However, the key molecular mechanisms and signaling pathways participating in VSMCs phenotypic switching have still not been fully elucidated despite long-term efforts by cardiovascular researchers. In this review, we provide an updated summary of the recent studies and systematic knowledge of VSMCs phenotypic switching in atherosclerosis, in-stent restenosis, aortic aneurysms, and vascular calcification, which may help guide future research and provide novel insights into the prevention and treatment of related diseases.https://www.mdpi.com/2073-4409/11/24/4060vascular smooth muscle cellatherosclerosisneointimal hyperplasiaaortic aneurysmsvascular calcification |
| spellingShingle | Hao-Yue Tang Ai-Qun Chen Huan Zhang Xiao-Fei Gao Xiang-Quan Kong Jun-Jie Zhang Vascular Smooth Muscle Cells Phenotypic Switching in Cardiovascular Diseases Cells vascular smooth muscle cell atherosclerosis neointimal hyperplasia aortic aneurysms vascular calcification |
| title | Vascular Smooth Muscle Cells Phenotypic Switching in Cardiovascular Diseases |
| title_full | Vascular Smooth Muscle Cells Phenotypic Switching in Cardiovascular Diseases |
| title_fullStr | Vascular Smooth Muscle Cells Phenotypic Switching in Cardiovascular Diseases |
| title_full_unstemmed | Vascular Smooth Muscle Cells Phenotypic Switching in Cardiovascular Diseases |
| title_short | Vascular Smooth Muscle Cells Phenotypic Switching in Cardiovascular Diseases |
| title_sort | vascular smooth muscle cells phenotypic switching in cardiovascular diseases |
| topic | vascular smooth muscle cell atherosclerosis neointimal hyperplasia aortic aneurysms vascular calcification |
| url | https://www.mdpi.com/2073-4409/11/24/4060 |
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