Molecular Chaperones and miRNAs in Epilepsy: Pathogenic Implications and Therapeutic Prospects
Epilepsy is a pathologic condition with high prevalence and devastating consequences for the patient and its entourage. Means for accurate diagnosis of type, patient monitoring for predicting seizures and follow up, and efficacious treatment are desperately needed. To improve this adverse outcome, m...
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| Format: | Article |
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MDPI AG
2021-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/16/8601 |
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| author | Leila Zummo Alessandra Maria Vitale Celeste Caruso Bavisotto Marco De Curtis Rita Garbelli Anna Teresa Giallonardo Carlo Di Bonaventura Martina Fanella Everly Conway de Macario Francesco Cappello Alberto J. L. Macario Antonella Marino Gammazza |
| author_facet | Leila Zummo Alessandra Maria Vitale Celeste Caruso Bavisotto Marco De Curtis Rita Garbelli Anna Teresa Giallonardo Carlo Di Bonaventura Martina Fanella Everly Conway de Macario Francesco Cappello Alberto J. L. Macario Antonella Marino Gammazza |
| author_sort | Leila Zummo |
| collection | DOAJ |
| description | Epilepsy is a pathologic condition with high prevalence and devastating consequences for the patient and its entourage. Means for accurate diagnosis of type, patient monitoring for predicting seizures and follow up, and efficacious treatment are desperately needed. To improve this adverse outcome, miRNAs and the chaperone system (CS) are promising targets to understand pathogenic mechanisms and for developing theranostics applications. miRNAs implicated in conditions known or suspected to favor seizures such as neuroinflammation, to promote epileptic tolerance and neuronal survival, to regulate seizures, and others showing variations in expression levels related to seizures are promising candidates as useful biomarkers for diagnosis and patient monitoring, and as targets for developing novel therapies. Components of the CS are also promising as biomarkers and as therapeutic targets, since they participate in epileptogenic pathways and in cytoprotective mechanisms in various epileptogenic brain areas, even if what they do and how is not yet clear. The data in this review should help in the identification of molecular targets among the discussed miRNAs and CS components for research aiming at understanding epileptogenic mechanisms and, subsequently, develop means for predicting/preventing seizures and treating the disease. |
| first_indexed | 2024-03-10T08:44:52Z |
| format | Article |
| id | doaj.art-7d9fdf002d9b4920a20a521b0c1d7eb0 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T08:44:52Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-7d9fdf002d9b4920a20a521b0c1d7eb02023-11-22T07:57:37ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-08-012216860110.3390/ijms22168601Molecular Chaperones and miRNAs in Epilepsy: Pathogenic Implications and Therapeutic ProspectsLeila Zummo0Alessandra Maria Vitale1Celeste Caruso Bavisotto2Marco De Curtis3Rita Garbelli4Anna Teresa Giallonardo5Carlo Di Bonaventura6Martina Fanella7Everly Conway de Macario8Francesco Cappello9Alberto J. L. Macario10Antonella Marino Gammazza11Department of Biomedicine, Neuroscience and Advanced Diagnostics, Section of Human Anatomy, University of Palermo, 90127 Palermo, ItalyDepartment of Biomedicine, Neuroscience and Advanced Diagnostics, Section of Human Anatomy, University of Palermo, 90127 Palermo, ItalyDepartment of Biomedicine, Neuroscience and Advanced Diagnostics, Section of Human Anatomy, University of Palermo, 90127 Palermo, ItalyEpilepsy Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, ItalyEpilepsy Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, ItalyDepartment of Human Neurosciences “Sapienza”, University of Rome, 00185 Rome, ItalyDepartment of Human Neurosciences “Sapienza”, University of Rome, 00185 Rome, ItalyDepartment of Human Neurosciences “Sapienza”, University of Rome, 00185 Rome, ItalyDepartment of Microbiology and Immunology, School of Medicine, University of Maryland at Baltimore-Institute of Marine and Environmental Technology (IMET), Baltimore, MD 21202, USADepartment of Biomedicine, Neuroscience and Advanced Diagnostics, Section of Human Anatomy, University of Palermo, 90127 Palermo, ItalyEuro-Mediterranean Institute of Science and Technology (IEMEST), 90139 Palermo, ItalyDepartment of Biomedicine, Neuroscience and Advanced Diagnostics, Section of Human Anatomy, University of Palermo, 90127 Palermo, ItalyEpilepsy is a pathologic condition with high prevalence and devastating consequences for the patient and its entourage. Means for accurate diagnosis of type, patient monitoring for predicting seizures and follow up, and efficacious treatment are desperately needed. To improve this adverse outcome, miRNAs and the chaperone system (CS) are promising targets to understand pathogenic mechanisms and for developing theranostics applications. miRNAs implicated in conditions known or suspected to favor seizures such as neuroinflammation, to promote epileptic tolerance and neuronal survival, to regulate seizures, and others showing variations in expression levels related to seizures are promising candidates as useful biomarkers for diagnosis and patient monitoring, and as targets for developing novel therapies. Components of the CS are also promising as biomarkers and as therapeutic targets, since they participate in epileptogenic pathways and in cytoprotective mechanisms in various epileptogenic brain areas, even if what they do and how is not yet clear. The data in this review should help in the identification of molecular targets among the discussed miRNAs and CS components for research aiming at understanding epileptogenic mechanisms and, subsequently, develop means for predicting/preventing seizures and treating the disease.https://www.mdpi.com/1422-0067/22/16/8601epilepsytemporal lobe epilepsymiRNAchaperone systemmolecular chaperones |
| spellingShingle | Leila Zummo Alessandra Maria Vitale Celeste Caruso Bavisotto Marco De Curtis Rita Garbelli Anna Teresa Giallonardo Carlo Di Bonaventura Martina Fanella Everly Conway de Macario Francesco Cappello Alberto J. L. Macario Antonella Marino Gammazza Molecular Chaperones and miRNAs in Epilepsy: Pathogenic Implications and Therapeutic Prospects International Journal of Molecular Sciences epilepsy temporal lobe epilepsy miRNA chaperone system molecular chaperones |
| title | Molecular Chaperones and miRNAs in Epilepsy: Pathogenic Implications and Therapeutic Prospects |
| title_full | Molecular Chaperones and miRNAs in Epilepsy: Pathogenic Implications and Therapeutic Prospects |
| title_fullStr | Molecular Chaperones and miRNAs in Epilepsy: Pathogenic Implications and Therapeutic Prospects |
| title_full_unstemmed | Molecular Chaperones and miRNAs in Epilepsy: Pathogenic Implications and Therapeutic Prospects |
| title_short | Molecular Chaperones and miRNAs in Epilepsy: Pathogenic Implications and Therapeutic Prospects |
| title_sort | molecular chaperones and mirnas in epilepsy pathogenic implications and therapeutic prospects |
| topic | epilepsy temporal lobe epilepsy miRNA chaperone system molecular chaperones |
| url | https://www.mdpi.com/1422-0067/22/16/8601 |
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