Interleukin‐18 produced by bone marrow‐derived stromal cells supports T‐cell acute leukaemia progression

Interleukin‐18 produced by bone marrow‐derived stromal cells supports T‐cell acute leukaemia progression

Abstract Development of novel therapies is critical for T‐cell acute leukaemia (T‐ALL). Here, we investigated the effect of inhibiting the MAPK/MEK/ERK pathway on T‐ALL cell growth. Unexpectedly, MEK inhibitors (MEKi) enhanced growth of 70% of human T‐ALL cell samples cultured on stromal cells indep...

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Bibliographic Details
Main Authors: Benjamin Uzan, Sandrine Poglio, Bastien Gerby, Ching‐Lien Wu, Julia Gross, Florence Armstrong, Julien Calvo, Xavier Cahu, Caroline Deswarte, Florent Dumont, Diana Passaro, Corinne Besnard‐Guérin, Thierry Leblanc, André Baruchel, Judith Landman‐Parker, Paola Ballerini, Véronique Baud, Jacques Ghysdael, Frédéric Baleydier, Francoise Porteu, Francoise Pflumio
Format: Article
Language:English
Published: Springer Nature 2014-06-01
Series:EMBO Molecular Medicine
Subjects:
IL‐18
inflammation
stromal cells
T‐ALL
Online Access:https://doi.org/10.1002/emmm.201303286

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