HBeAg negative chronic hepatitis B in South Asia
Chronic Hepatitis B (CHB) infection has an intermediate prevalence rate in South Asian countries, except for Nepal and Sri Lanka where it has a low rate. HBeAg negative CHB infection has been found to be more pronounced in this part of the world. As described previously, CHB infection has two phases...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Khesar Gyalpo University of Medical Sciences of Bh
2016-11-01
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| Series: | Bhutan Health Journal |
| Online Access: | https://bhj.com.bt/index.php/bhj/article/view/30 |
| _version_ | 1797650139731460096 |
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| author | Ananta Shrestha Thupten Kelsang Lama Sudhamshu KC Dilip Sharma Sandip Khadka Guru Prasad Dhakal Birendra Prasad Gupta |
| author_facet | Ananta Shrestha Thupten Kelsang Lama Sudhamshu KC Dilip Sharma Sandip Khadka Guru Prasad Dhakal Birendra Prasad Gupta |
| author_sort | Ananta Shrestha |
| collection | DOAJ |
| description | Chronic Hepatitis B (CHB) infection has an intermediate prevalence rate in South Asian countries, except for Nepal and Sri Lanka where it has a low rate. HBeAg negative CHB infection has been found to be more pronounced in this part of the world. As described previously, CHB infection has two phases with HBeAg positive and HBeAg negative based on ALT, DNA & biopsy. The latter was previously described to have a benign course. The later guidelines have distinguished HBeAg negative status into two categories with an inactive phase and a reactivation one. In this review article we have highlighted HBeAg Negative status burden in South Asian countries and shown that HBeAg negative CHB infection may not be as benign as previously thought. Furthermore , mutations at precore and basal core promoter region may contribute to disease severity in HBeAg negative CHB infection. |
| first_indexed | 2024-03-11T15:55:58Z |
| format | Article |
| id | doaj.art-7da19950bbbe4031b6d76965ac235ebf |
| institution | Directory Open Access Journal |
| issn | 2413-2993 2415-1114 |
| language | English |
| last_indexed | 2024-03-11T15:55:58Z |
| publishDate | 2016-11-01 |
| publisher | Khesar Gyalpo University of Medical Sciences of Bh |
| record_format | Article |
| series | Bhutan Health Journal |
| spelling | doaj.art-7da19950bbbe4031b6d76965ac235ebf2023-10-25T10:27:38ZengKhesar Gyalpo University of Medical Sciences of BhBhutan Health Journal2413-29932415-11142016-11-0122162210.47811/bhj.2930HBeAg negative chronic hepatitis B in South AsiaAnanta Shrestha0Thupten Kelsang Lama1Sudhamshu KC2Dilip Sharma3Sandip Khadka4Guru Prasad Dhakal5Birendra Prasad Gupta6Liver Foundation, Nepal.Department of Medicine, Hepatology wing, Civil Service hospital, Nepal.Department of Hepatology, NAMS, Bir Hospital, Nepal.Department of Hepatology, NAMS, Bir Hospital, Nepal.Department of Hepatology, NAMS, Bir Hospital, Nepal.Department of Medicine, Jigme Dorji Wangchuck National Referral Hospital, Bhutan.Central Department of Biotechnology, Tribhuvan University, Nepal.Chronic Hepatitis B (CHB) infection has an intermediate prevalence rate in South Asian countries, except for Nepal and Sri Lanka where it has a low rate. HBeAg negative CHB infection has been found to be more pronounced in this part of the world. As described previously, CHB infection has two phases with HBeAg positive and HBeAg negative based on ALT, DNA & biopsy. The latter was previously described to have a benign course. The later guidelines have distinguished HBeAg negative status into two categories with an inactive phase and a reactivation one. In this review article we have highlighted HBeAg Negative status burden in South Asian countries and shown that HBeAg negative CHB infection may not be as benign as previously thought. Furthermore , mutations at precore and basal core promoter region may contribute to disease severity in HBeAg negative CHB infection.https://bhj.com.bt/index.php/bhj/article/view/30 |
| spellingShingle | Ananta Shrestha Thupten Kelsang Lama Sudhamshu KC Dilip Sharma Sandip Khadka Guru Prasad Dhakal Birendra Prasad Gupta HBeAg negative chronic hepatitis B in South Asia Bhutan Health Journal |
| title | HBeAg negative chronic hepatitis B in South Asia |
| title_full | HBeAg negative chronic hepatitis B in South Asia |
| title_fullStr | HBeAg negative chronic hepatitis B in South Asia |
| title_full_unstemmed | HBeAg negative chronic hepatitis B in South Asia |
| title_short | HBeAg negative chronic hepatitis B in South Asia |
| title_sort | hbeag negative chronic hepatitis b in south asia |
| url | https://bhj.com.bt/index.php/bhj/article/view/30 |
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