Molecular mechanisms of osteosarcoma metastasis and possible treatment opportunities
In osteosarcoma patients, metastasis of the primary cancer is the leading cause of death. At present, management options to prevent metastasis are limited and non-curative. In this study, we review the current state of knowledge on the molecular mechanisms of metastasis and discuss promising new the...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-05-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1117867/full |
| _version_ | 1797836087241998336 |
|---|---|
| author | Xinhui Du Xinhui Du Xinhui Du Hua Wei Boya Zhang Boya Zhang Boya Zhang Bangmin Wang Bangmin Wang Bangmin Wang Zhehuang Li Zhehuang Li Zhehuang Li Lon Kai Pang Ruiying Zhao Weitao Yao Weitao Yao Weitao Yao |
| author_facet | Xinhui Du Xinhui Du Xinhui Du Hua Wei Boya Zhang Boya Zhang Boya Zhang Bangmin Wang Bangmin Wang Bangmin Wang Zhehuang Li Zhehuang Li Zhehuang Li Lon Kai Pang Ruiying Zhao Weitao Yao Weitao Yao Weitao Yao |
| author_sort | Xinhui Du |
| collection | DOAJ |
| description | In osteosarcoma patients, metastasis of the primary cancer is the leading cause of death. At present, management options to prevent metastasis are limited and non-curative. In this study, we review the current state of knowledge on the molecular mechanisms of metastasis and discuss promising new therapies to combat osteosarcoma metastasis. Genomic and epigenomic changes, metabolic reprogramming, transcription factors, dysregulation of physiologic pathways, and alterations to the tumor microenvironment are some of the changes reportedly involved in the regulation of osteosarcoma metastasis. Key factors within the tumor microenvironment include infiltrating lymphocytes, macrophages, cancer-associated fibroblasts, platelets, and extracellular components such as vesicles, proteins, and other secreted molecules. We conclude by discussing potential osteosarcoma-limiting agents and their clinical studies. |
| first_indexed | 2024-04-09T15:04:05Z |
| format | Article |
| id | doaj.art-7da2dcbac4894288a8a9ccd74bb6a4f5 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-09T15:04:05Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-7da2dcbac4894288a8a9ccd74bb6a4f52023-05-01T04:27:33ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-05-011310.3389/fonc.2023.11178671117867Molecular mechanisms of osteosarcoma metastasis and possible treatment opportunitiesXinhui Du0Xinhui Du1Xinhui Du2Hua Wei3Boya Zhang4Boya Zhang5Boya Zhang6Bangmin Wang7Bangmin Wang8Bangmin Wang9Zhehuang Li10Zhehuang Li11Zhehuang Li12Lon Kai Pang13Ruiying Zhao14Weitao Yao15Weitao Yao16Weitao Yao17Bone Soft Tissue Department, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, ChinaKey Laboratory for Digital Assessment of Spinal-Pelvic Tumor and Surgical Aid Tools Design (Zhengzhou), Zhengzhou, Henan, ChinaKey Laboratory for Perioperative Digital Assessment of Bone Tumors (Henan), Zhengzhou, Henan, ChinaDepartment of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, ChinaBone Soft Tissue Department, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, ChinaKey Laboratory for Digital Assessment of Spinal-Pelvic Tumor and Surgical Aid Tools Design (Zhengzhou), Zhengzhou, Henan, ChinaKey Laboratory for Perioperative Digital Assessment of Bone Tumors (Henan), Zhengzhou, Henan, ChinaBone Soft Tissue Department, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, ChinaKey Laboratory for Digital Assessment of Spinal-Pelvic Tumor and Surgical Aid Tools Design (Zhengzhou), Zhengzhou, Henan, ChinaKey Laboratory for Perioperative Digital Assessment of Bone Tumors (Henan), Zhengzhou, Henan, ChinaBone Soft Tissue Department, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, ChinaKey Laboratory for Digital Assessment of Spinal-Pelvic Tumor and Surgical Aid Tools Design (Zhengzhou), Zhengzhou, Henan, ChinaKey Laboratory for Perioperative Digital Assessment of Bone Tumors (Henan), Zhengzhou, Henan, ChinaBaylor College of Medicine, Houston, TX, United StatesDepartment of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, United StatesBone Soft Tissue Department, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, ChinaKey Laboratory for Digital Assessment of Spinal-Pelvic Tumor and Surgical Aid Tools Design (Zhengzhou), Zhengzhou, Henan, ChinaKey Laboratory for Perioperative Digital Assessment of Bone Tumors (Henan), Zhengzhou, Henan, ChinaIn osteosarcoma patients, metastasis of the primary cancer is the leading cause of death. At present, management options to prevent metastasis are limited and non-curative. In this study, we review the current state of knowledge on the molecular mechanisms of metastasis and discuss promising new therapies to combat osteosarcoma metastasis. Genomic and epigenomic changes, metabolic reprogramming, transcription factors, dysregulation of physiologic pathways, and alterations to the tumor microenvironment are some of the changes reportedly involved in the regulation of osteosarcoma metastasis. Key factors within the tumor microenvironment include infiltrating lymphocytes, macrophages, cancer-associated fibroblasts, platelets, and extracellular components such as vesicles, proteins, and other secreted molecules. We conclude by discussing potential osteosarcoma-limiting agents and their clinical studies.https://www.frontiersin.org/articles/10.3389/fonc.2023.1117867/fullosteosarcomametastasisreprogrammingtumor microenvironmentmechanism |
| spellingShingle | Xinhui Du Xinhui Du Xinhui Du Hua Wei Boya Zhang Boya Zhang Boya Zhang Bangmin Wang Bangmin Wang Bangmin Wang Zhehuang Li Zhehuang Li Zhehuang Li Lon Kai Pang Ruiying Zhao Weitao Yao Weitao Yao Weitao Yao Molecular mechanisms of osteosarcoma metastasis and possible treatment opportunities Frontiers in Oncology osteosarcoma metastasis reprogramming tumor microenvironment mechanism |
| title | Molecular mechanisms of osteosarcoma metastasis and possible treatment opportunities |
| title_full | Molecular mechanisms of osteosarcoma metastasis and possible treatment opportunities |
| title_fullStr | Molecular mechanisms of osteosarcoma metastasis and possible treatment opportunities |
| title_full_unstemmed | Molecular mechanisms of osteosarcoma metastasis and possible treatment opportunities |
| title_short | Molecular mechanisms of osteosarcoma metastasis and possible treatment opportunities |
| title_sort | molecular mechanisms of osteosarcoma metastasis and possible treatment opportunities |
| topic | osteosarcoma metastasis reprogramming tumor microenvironment mechanism |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1117867/full |
| work_keys_str_mv | AT xinhuidu molecularmechanismsofosteosarcomametastasisandpossibletreatmentopportunities AT xinhuidu molecularmechanismsofosteosarcomametastasisandpossibletreatmentopportunities AT xinhuidu molecularmechanismsofosteosarcomametastasisandpossibletreatmentopportunities AT huawei molecularmechanismsofosteosarcomametastasisandpossibletreatmentopportunities AT boyazhang molecularmechanismsofosteosarcomametastasisandpossibletreatmentopportunities AT boyazhang molecularmechanismsofosteosarcomametastasisandpossibletreatmentopportunities AT boyazhang molecularmechanismsofosteosarcomametastasisandpossibletreatmentopportunities AT bangminwang molecularmechanismsofosteosarcomametastasisandpossibletreatmentopportunities AT bangminwang molecularmechanismsofosteosarcomametastasisandpossibletreatmentopportunities AT bangminwang molecularmechanismsofosteosarcomametastasisandpossibletreatmentopportunities AT zhehuangli molecularmechanismsofosteosarcomametastasisandpossibletreatmentopportunities AT zhehuangli molecularmechanismsofosteosarcomametastasisandpossibletreatmentopportunities AT zhehuangli molecularmechanismsofosteosarcomametastasisandpossibletreatmentopportunities AT lonkaipang molecularmechanismsofosteosarcomametastasisandpossibletreatmentopportunities AT ruiyingzhao molecularmechanismsofosteosarcomametastasisandpossibletreatmentopportunities AT weitaoyao molecularmechanismsofosteosarcomametastasisandpossibletreatmentopportunities AT weitaoyao molecularmechanismsofosteosarcomametastasisandpossibletreatmentopportunities AT weitaoyao molecularmechanismsofosteosarcomametastasisandpossibletreatmentopportunities |