Correlates of severity in a clinical staging model of schizophrenia: a cross-sectional study among 158 subjects
Abstract Background Clinical staging has been widely used to predict and optimize the treatment of medical disorders. Different models have been proposed to map the development, progression, and extension of psychiatric disorders over time, mainly for schizophrenia. The primary objective of this stu...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | BMC Psychiatry |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12888-023-05144-6 |
| _version_ | 1797557386584522752 |
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| author | Fatima Hamieh Souheil Hallit Chadia Haddad Sahar Obeid Francois Kazour |
| author_facet | Fatima Hamieh Souheil Hallit Chadia Haddad Sahar Obeid Francois Kazour |
| author_sort | Fatima Hamieh |
| collection | DOAJ |
| description | Abstract Background Clinical staging has been widely used to predict and optimize the treatment of medical disorders. Different models have been proposed to map the development, progression, and extension of psychiatric disorders over time, mainly for schizophrenia. The primary objective of this study was to classify patients with psychosis according to the McGorry staging model and compare factors between the different stages. Methods This was a cross-sectional study, collecting data from 158 patients hospitalized for schizophrenia/psychosis. The survey included the Mini International Neuropsychiatric Interview (MINI), Positive and Negative Symptom Scale (PANSS), Montgomery-Asberg Depression Rating Scale (MADRS), Yong Mania Rating Scale (YMRS), Clinical Global Impression (CGI) scale, and the McGorry staging model. Results Patients have been classified into three clinical stages: relapse of psychotic disorder (43%), multiple relapses (47.5%), and persistent and severe illness (9.5%). A higher mean duration of hospitalization, psychotic symptoms (PANSS total scale and subscales), chlorpromazine equivalent dose, and number of antipsychotic treatments were found among participants in Stage 4 as compared to the other groups. However, a significantly higher mean GAF scale was found among participants in stage 3b as compared to the other groups. Conclusion Each stage in the McGorry staging model of schizophrenia is associated with well-defined clinical presentations, which help decide the appropriate treatment. Using such models in psychiatry can improve the diagnostic process and potential therapeutic interventions for patients suffering from mental disorders. |
| first_indexed | 2024-03-10T17:16:20Z |
| format | Article |
| id | doaj.art-7da6061bb7934683a69472d75bffe6ec |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-03-10T17:16:20Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-7da6061bb7934683a69472d75bffe6ec2023-11-20T10:29:35ZengBMCBMC Psychiatry1471-244X2023-09-012311810.1186/s12888-023-05144-6Correlates of severity in a clinical staging model of schizophrenia: a cross-sectional study among 158 subjectsFatima Hamieh0Souheil Hallit1Chadia Haddad2Sahar Obeid3Francois Kazour4Faculty of Sciences, Lebanese UniversitySchool of Medicine and Medical Sciences, Holy Spirit University of KaslikResearch Department, Psychiatric Hospital of the CrossSocial and Education Sciences Department, School of Arts and Sciences, Lebanese American UniversityDepartment of Psychiatry, CHU AngersAbstract Background Clinical staging has been widely used to predict and optimize the treatment of medical disorders. Different models have been proposed to map the development, progression, and extension of psychiatric disorders over time, mainly for schizophrenia. The primary objective of this study was to classify patients with psychosis according to the McGorry staging model and compare factors between the different stages. Methods This was a cross-sectional study, collecting data from 158 patients hospitalized for schizophrenia/psychosis. The survey included the Mini International Neuropsychiatric Interview (MINI), Positive and Negative Symptom Scale (PANSS), Montgomery-Asberg Depression Rating Scale (MADRS), Yong Mania Rating Scale (YMRS), Clinical Global Impression (CGI) scale, and the McGorry staging model. Results Patients have been classified into three clinical stages: relapse of psychotic disorder (43%), multiple relapses (47.5%), and persistent and severe illness (9.5%). A higher mean duration of hospitalization, psychotic symptoms (PANSS total scale and subscales), chlorpromazine equivalent dose, and number of antipsychotic treatments were found among participants in Stage 4 as compared to the other groups. However, a significantly higher mean GAF scale was found among participants in stage 3b as compared to the other groups. Conclusion Each stage in the McGorry staging model of schizophrenia is associated with well-defined clinical presentations, which help decide the appropriate treatment. Using such models in psychiatry can improve the diagnostic process and potential therapeutic interventions for patients suffering from mental disorders.https://doi.org/10.1186/s12888-023-05144-6StagingSchizophreniaPsychosisMoodAntipsychotics |
| spellingShingle | Fatima Hamieh Souheil Hallit Chadia Haddad Sahar Obeid Francois Kazour Correlates of severity in a clinical staging model of schizophrenia: a cross-sectional study among 158 subjects BMC Psychiatry Staging Schizophrenia Psychosis Mood Antipsychotics |
| title | Correlates of severity in a clinical staging model of schizophrenia: a cross-sectional study among 158 subjects |
| title_full | Correlates of severity in a clinical staging model of schizophrenia: a cross-sectional study among 158 subjects |
| title_fullStr | Correlates of severity in a clinical staging model of schizophrenia: a cross-sectional study among 158 subjects |
| title_full_unstemmed | Correlates of severity in a clinical staging model of schizophrenia: a cross-sectional study among 158 subjects |
| title_short | Correlates of severity in a clinical staging model of schizophrenia: a cross-sectional study among 158 subjects |
| title_sort | correlates of severity in a clinical staging model of schizophrenia a cross sectional study among 158 subjects |
| topic | Staging Schizophrenia Psychosis Mood Antipsychotics |
| url | https://doi.org/10.1186/s12888-023-05144-6 |
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